Stage-specific substrate phosphorylation by a Ca2+/calmodulin-dependent protein kinase in Trypanosoma cruzi
The presence of Ca2+/calmodulin (Ca2+/CaM)-dependent protein kinase (TcCaM K) and some stage-specific substrates that appeared during morphogenesis of the parasite Trypanosoma cruzi were identified. Western blot analysis using a polyclonal antibody against rat brain CaM K type II recognized the same...
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Blackwell Publishing Inc.
1998
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10542caa a22009377a 4500 | ||
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| 001 | PAPER-2917 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203223.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0032127976 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JEMIE | ||
| 100 | 1 | |a Ogueta, S.B. | |
| 245 | 1 | 0 | |a Stage-specific substrate phosphorylation by a Ca2+/calmodulin-dependent protein kinase in Trypanosoma cruzi |
| 260 | |b Blackwell Publishing Inc. |c 1998 | ||
| 270 | 1 | 0 | |m Ogueta, S.B.; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, United States; email: ogueta@jsei.ucla.edu |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Stojdl, D.F., Clarke, M.W., Trypanosoma brucei: Analysis of cytoplasmic Ca2+ during differentiation of bloodstream stages in vitro (1996) Exp. Parasitol., 83, pp. 134-146 | ||
| 504 | |a Strack, S., Choi, S., Lovinger, D.M., Colbran, R.J., Translocation of autophosphorylated calcium/calmodulin-dependent protein kinase II to the postsynaptic density (1997) J. Biol.Chem., 272, pp. 13467-13470 | ||
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| 504 | |a Tokumitsu, H., Chijiwa, T., Hagiwara, M., Mizutani, A., Teresawa, M., Hidaka, H., KN-62, 1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L -tyrosyl]-4-phenylpiperazine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (1990) J. Biol. Chem., 265, pp. 4315-4320 | ||
| 504 | |a Zalewska, T., Domanska-Janik, K., Brain ischaemia transiently activates Ca2+/calmodulin-independent protein kinase II (1996) Neuroreport, 7, pp. 637-641 | ||
| 520 | 3 | |a The presence of Ca2+/calmodulin (Ca2+/CaM)-dependent protein kinase (TcCaM K) and some stage-specific substrates that appeared during morphogenesis of the parasite Trypanosoma cruzi were identified. Western blot analysis using a polyclonal antibody against rat brain CaM K type II recognized the same subunit composition (52, 59/62 kDa) observed for the mammalian enzyme, as well as the previously characterized TcCaM K found in epimastigote forms. Differential protein phosphorylation profiles were observed after enzyme activation in the stages of T. cruzi. Co-immunoprecipitation of stage-specific substrates with the TcCaM K suggested that the enzyme might be involved in the phosphorylation of a different set of proteins through the life cycle. Three phosphoproteins, pp105 and pp87 from epimastigotes and pp23 from trypomastigotes were identified as potential substrates for TcCaM K. The characterization of these endogenous stage markers might be a useful tool to understand the developmental cycles of these pathogenic protozoa. |l eng | |
| 593 | |a Inst. Invest. Ing. Genet. Biol. M., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Jules Stein Eye Institute, University of California, Los Angeles, CA 90095, United States | ||
| 593 | |a Michigan State University, Department of Energy, Michigan State University, East Lansing, MI 48824, United States | ||
| 690 | 1 | 0 | |a AMASTIGOTES |
| 690 | 1 | 0 | |a DIFFERENTIATION |
| 690 | 1 | 0 | |a EPIMASTIGOTES |
| 690 | 1 | 0 | |a TRYPANOSOMATIDS |
| 690 | 1 | 0 | |a TRYPOMASTIGOTES |
| 690 | 1 | 0 | |a CALCIUM |
| 690 | 1 | 0 | |a CALMODULIN |
| 690 | 1 | 0 | |a DEVELOPMENTAL CYCLE |
| 690 | 1 | 0 | |a ENZYME ACTIVATION |
| 690 | 1 | 0 | |a IDENTIFICATION |
| 690 | 1 | 0 | |a MORPHOGENESIS |
| 690 | 1 | 0 | |a PHOSPHORYLATION |
| 690 | 1 | 0 | |a POLYCLONAL ANTIBODY |
| 690 | 1 | 0 | |a PROTEIN KINASE |
| 690 | 1 | 0 | |a WESTERN BLOTTING |
| 690 | 1 | 0 | |a TRYPANOSOMA CRUZI |
| 700 | 1 | |a Macintosh, G.C. | |
| 700 | 1 | |a Téllez-Iñon, M.T. | |
| 773 | 0 | |d Blackwell Publishing Inc., 1998 |g v. 45 |h pp. 392-396 |k n. 4 |p J. Eukaryotic Microbiol. |x 10665234 |t Journal of Eukaryotic Microbiology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_10665234_v45_n4_p392_Ogueta |y Handle |
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