Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L leaves
Meliacine (MA), a peptide isolated from leaves of the high plant Melia azedarach L inhibited the multiplication of foot and mouth disease virus (FMDV) in BHK-21 cells. In this report, we establish that the MA-inhibitable process takes place within the first hour of the viral reproductive cycle. MA h...
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1998
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| LEADER | 10105caa a22009497a 4500 | ||
|---|---|---|---|
| 001 | PAPER-2956 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203225.0 | ||
| 008 | 190411s1998 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0031961054 | |
| 024 | 7 | |2 cas |a Antiviral Agents; meliacin; Peptides; Plant Extracts; Plant Proteins | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ARVID | ||
| 100 | 1 | |a Wachsman, M.B. | |
| 245 | 1 | 0 | |a Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L leaves |
| 260 | |c 1998 | ||
| 270 | 1 | 0 | |m Wachsman, M.B.; Universidad de Buenos Aires, Departamento de Quimica Biologica, Facul. de Cienc. Exactas./Naturales, Piso 4, 1428 Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Andrei, G.M., Coto, C.E., De Torres, R.A., Ensayos de citotoxicidad y actividad antiviral de extractos crudos y semipurificadode hojas verdes de Melia azedarach L (1985) Rev Arg Microbiol, 17, pp. 187-194 | ||
| 504 | |a Andrei, G.M., Damonte, E.B., De Torres, R.A., Coto, C.E., Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L (1988) Antiviral Res, 9, pp. 221-231 | ||
| 504 | |a Andrei, G.M., Couto, A.G., Lederkremer, R.M., Goto, C.E., Purification and partial characterization of an antiviral active peptide from Melia azedarach L (1994) Antiviral Chem Chemother, 5, pp. 105-110 | ||
| 504 | |a Barteling, S.I., Vreeswijk, J., Development in foot-and-mouth disease vaccines (1991) Vaccine, 9, pp. 75-88 | ||
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| 504 | |a Mandel, B., The relationship between penetration and uncoating of poliovirus in Hela cells (1967) Virology, 31, pp. 702-712 | ||
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| 504 | |a Mason, P.W., Baxt, B., Brown, F., Harber, J., Murdin, A., Wimmer, E., Antibody-complexed foot-and-mouth disease virus, but not poliovirus, can infect normally in susceptible cells via the Fc receptor (1993) Virology, 192, pp. 568-577 | ||
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| 504 | |a Singh, A.K., Sidhu, G.S., Friedman, R.M., Maheshwari, R.K., Mechanism of enhancement of the antiviral action of Interferon against herpes simplex virus-1 by chloroquine (1996) J Interferon Cytokine Res, 16, pp. 725-731 | ||
| 504 | |a Singh, I.R., Suomalainen, M., Varadarajan, S., Garoff, H., Helenius, A., Multiple mechanisms for inhibition of entry and uncoating of superinfecting Semliki Forest virus (1997) Virology, 231, pp. 59-71 | ||
| 504 | |a Villamil, S.M., Alché, L.E., Coto, C.E., Inhibition of herpes simplex type-1 multiplication by meliacine, a peptide of plant origin (1995) Antiviral Chem Chemother, 6, pp. 239-244 | ||
| 504 | |a Wachsman, M.B., Coto, C.E., Susceptibility of picornaviruses to an antiviral of vegetal origin (meliacine) (1995) Rev Arg Microbiol, 27, pp. 33-37 | ||
| 504 | |a Wachsman, M.B., Damonte, E.B., Coto, C.E., De Torres, R.A., Antiviral effects of Melia azedarach L leaves extracts on sindhis virus infected cells (1987) Antiviral Res, 8, pp. 1-12 | ||
| 520 | 3 | |a Meliacine (MA), a peptide isolated from leaves of the high plant Melia azedarach L inhibited the multiplication of foot and mouth disease virus (FMDV) in BHK-21 cells. In this report, we establish that the MA-inhibitable process takes place within the first hour of the viral reproductive cycle. MA had no virucidal effect and did not affect adsorption and penetration of the virus in cells. In experiments with neutral red-labeled virus, it was found that MA significantly suppressed the development of photoresistance of the virus in infected cells. In untreated cultures nearly all virus which adsorbed to cells was uncoated within 1 h at 37°C, whereas in treated cultures, even after 3 h only 3% of the virus was uncoated. Labeling of BHK-21 cells with acridine orange showed that MA affects the pH of intracellular acidic vesicles. Therefore, it is concluded that MA prevents the process of uncoating of FMDV in BHK-21 cells by inhibiting vacuolar acidification. Foot and mouth disease virus (FMDV) is a pathogen that affects a wide range of cloven-hoofed animals of agricultural and economic importance throughout the world. The seven serotypes of FMDV (types O, A, C, and Asia and the South African territories types 1, 2 and 3) constitute the Aphthovirus gene of the family Picornaviridae. FMDV is a small, non-enveloped, icosahedral virus with a single-stranded, positive-sense RNA genome of approximately 8 400 nucleotides [8]. Control of the disease is carried out using inactivated vaccines [4], but the major problem in control by vaccination is the antigenic variation of the virus [9, 10]. |l eng | |
| 593 | |a Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 1428, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ANTIVIRAL ACTIVITY |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a FOOT AND MOUTH DISEASE VIRUS |
| 690 | 1 | 0 | |a PHYSICAL RESISTANCE |
| 690 | 1 | 0 | |a SEROTYPE |
| 690 | 1 | 0 | |a VIRUS GENOME |
| 690 | 1 | 0 | |a VIRUS INHIBITION |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a APHTHOVIRUS |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CRICETINAE |
| 690 | 1 | 0 | |a PEPTIDES |
| 690 | 1 | 0 | |a PLANT EXTRACTS |
| 690 | 1 | 0 | |a PLANT LEAVES |
| 690 | 1 | 0 | |a PLANT PROTEINS |
| 690 | 1 | 0 | |a TREES |
| 650 | 1 | 7 | |2 spines |a VIRUS RNA |
| 700 | 1 | |a Castilla, V. | |
| 700 | 1 | |a Coto, C.E. | |
| 773 | 0 | |d 1998 |g v. 143 |h pp. 581-590 |k n. 3 |p Arch. Virol. |x 03048608 |t Archives of Virology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1007/s007050050314 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03048608_v143_n3_p581_Wachsman |y Handle |
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