Aluminium accumulation in chronic renal failure affects erythropoises
Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency w...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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1997
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| Acceso en línea: | Registro en Scopus Handle Registro en la Biblioteca Digital |
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| LEADER | 10512caa a22010697a 4500 | ||
|---|---|---|---|
| 001 | PAPER-3345 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203249.0 | ||
| 008 | 190411s1997 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0030875702 | |
| 024 | 7 | |2 cas |a aluminum citrate, 31142-56-0 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a NEPHF | ||
| 100 | 1 | |a Nesse, A. | |
| 245 | 1 | 0 | |a Aluminium accumulation in chronic renal failure affects erythropoises |
| 260 | |c 1997 | ||
| 270 | 1 | 0 | |m Rizzo, N.; Departamento de Quimica Biologica, FCEN, Ciudad Universitaria, (1428) Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Wills, M.R., Savory, J., Aluminum poisoning. Dialysis encephalopathy, osteomalacia, and anemia (1983) Lancet, 2, pp. 29-34 | ||
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| 504 | |a Arieff, A.I., Cooper, J.D., Armstrong, D., Lazarowitz, V.C., Dementia, renal failure, and brain aluminum (1979) Ann. Intern. Med., 90, pp. 741-747 | ||
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| 504 | |a Poisson, M., Mashaly, R., Lebkiri, B., Dialysis encephalopathy: Recovery after interruption of aluminum intake (1978) Br. Med. J., 4, pp. 1610-1611 | ||
| 504 | |a Smith, P.S., McClure, J., Localization of aluminium by histochemical and electron probe X-ray microanalytical techniques in bone tissue of cases of renal osteodystrophy (1982) J. Clin. Pathol., 35, pp. 1283-1293 | ||
| 504 | |a Ellis, H.A., McCarthy, J.H., Herrington, J., Bone aluminium in haemodialysed patients and in rats injected with aluminium chloride: Relationship to impaired bone mineralization (1979) J. Clin. Pathol., 32, pp. 832-844 | ||
| 504 | |a Sherrard, D.J., Hercz, G., Pei, Y., The spectrum of bone disease in end-stage renal failure. An evolving disorder (1993) Kidney Int., 43, pp. 436-442 | ||
| 504 | |a Maloney, N.A., Ott, S.M., Alfrey, A.C., Miller, N.L., Coburn, J.W., Sherrard, D.J., Histological quantitation of aluminium in iliac bone from patients with renal failure (1982) J. Lab. Clin. Med., 99, pp. 206-216 | ||
| 504 | |a Bia, M.J., Cooper, K., Schnall, S., Aluminum induced anemia: Pathogenesis and treatment in patients on chronic hemodialysis (1989) Kidney Int., 36, pp. 852-858 | ||
| 504 | |a Eschbach, J.W., Adamson, J.W., Anemia in renal disease (1994) Diseases of the Kidney, pp. 2743-2758. , Schrier RW, Gottschalk CW (eds.) Little, Brown & Co., Boston | ||
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| 504 | |a Garbossa, G., Gutnisky, A., Nesse, A., Depressed erythroid progenitor cell activity in aluminum-overloaded mice (1996) Miner. Electrolyte Metab., 22, pp. 214-218 | ||
| 504 | |a Touam, M., Martínez, F., Lacour, B., Aluminium-induced reversible microcytic anemia in experimental chronic renal failure: Clinical and experimental studies (1983) Clin. Nephrol., 19, pp. 295-298 | ||
| 504 | |a Kaiser, L., Schwartz, K.A., Burnatowska-Hledin, M.A., Mayor, G.H., Microcytic anemia secondary to intraperitoneal aluminum in normal and uremic rats (1984) Kidney Int., 26, pp. 269-274 | ||
| 504 | |a Garbossa, G., Gutnisky, A., Nesse, A., The inhibitory action of aluminum on mouse bone marrow cell growth: Evidence for an erythropoietin- And transferrin-mediated mechanism (1994) Miner. Electrolyte Metab., 20, pp. 141-146 | ||
| 504 | |a Mladenovic, J., Aluminum inhibits erythropoiesis in vitro (1988) J. Clin. Invest., 81, pp. 1661-1665 | ||
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| 504 | |a Ormrod, D., Miller, T., Experimental uremia. Description of a model producing varying degrees of stable uremia (1980) Nephron, 26, pp. 249-254 | ||
| 504 | |a Velarde, F., Monge, C., Vidal, A., Carcagno, M., Criscuolo, M., Bozzini, C., Serum immunoreactive erythropoietin in high altitude natives with and without excessive erythrocytosis (1991) Exp. Hematol., 19, pp. 257-260 | ||
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| 504 | |a Drücke, T.B., Lacour, B., Touam, M., Effect of aluminum on hematopoiesis (1986) Kidney Int., 29 (18 SUPPL.), pp. S45-8 | ||
| 504 | |a Alfrey, A.C., Phosphate, aluminum, and other elements in chronic renal disease (1994) Diseases of the Kidney, pp. 3153-3166. , Schrier RW, Gottschalk CW (eds). Little Brown 6k Co., Boston | ||
| 504 | |a Mera, S.L., Aluminium, amyloid, and Alzheimer's disease (1991) Med. Labor. Sci., 48, pp. 283-295 | ||
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| 520 | 3 | |a Aluminium (Al) toxicity has been associated with anaemia in exposed patients with chronic renal failure (CRF). The present study was undertaken to determine whether the ingestion of Al citrate was able to affect erythropoiesis in rats with normal or impaired renal function. The renal insufficiency was induced by surgical procedures and control rats were sham operated. Twenty-four rats were allocated to four groups of six rats each: (A) Sham; (B) Sham+Al; (C) CRF; and (D) CRF+Al. The groups B and D received daily doses of Al citrate (0.5 μmol/g bodyweight) and the groups A and C, deionized water, via the intragastric route. At the end of the experimental period (15 weeks) cultures of late erythroid progenitor cells (CFU-E) stimulated with erythropoietin were performed and haematological parameters determined. The liver, kidney, brain, bone and serum Al amounts were quantified. The results are expressed as median and interquartile range. The CFU-E growth was found inhibited in B and D groups (A: 100; B: 74/54-83; C: 86/54-98; D: 46/39-53 %). The haematocrit values were significantly diminished in rats with renal insufficiency when compared to controls (A: 42/40-43; B: 45/42-46; C: 37/32-40 and D: 37/24-39 %). Serum Al accumulation was observed in B and D groups receiving Al (A: 8/5-12; B: 36/36-44; C: 5/5- 6; D: 45126-132 μg Al]l). No differences among groups were found in the liver and kidney Al contents, but uraemic state favoured Al accumulation in brain (A: 6/5.0-9.0; B: 4/3.8-4.3; C: 2/2.0-3.0; D: 15/12.0-21.0 μg Al/g tissue) and bone (A: 29/27-31; B: 30/29-39; C: 42/33-48; D: 68/56-79 μg Al/g tissue). We suggest that the heavy accumulation of Al in the bone compartment may result in a protracted endogenous exposure of bone marrow cells, affecting the erythropoiesis in vive. |l eng | |
| 593 | |a Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Inorgánica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Ctro. Estud. Farmacologicos y B., Consejo Nac. de Invest. Cie. y Tec., Buenos Aires, Argentina | ||
| 593 | |a Depto. de Quim. Biológica, Fac. de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón II, Piso 4, (1428) Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a ALUMINIUM AND ERYTHROPOIESIS |
| 690 | 1 | 0 | |a ALUMINUM |
| 690 | 1 | 0 | |a ALUMINUM TOXICITY |
| 690 | 1 | 0 | |a CHRONIC RENAL FAILURE |
| 690 | 1 | 0 | |a ALUMINUM CITRATE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BONE |
| 690 | 1 | 0 | |a BRAIN |
| 690 | 1 | 0 | |a CHRONIC KIDNEY FAILURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a ERYTHROPOIESIS |
| 690 | 1 | 0 | |a KIDNEY |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SERUM |
| 690 | 1 | 0 | |a TISSUE DISTRIBUTION |
| 690 | 1 | 0 | |a TOXICITY TESTING |
| 700 | 1 | |a Garbossa, G. | |
| 700 | 1 | |a Stripeikis, J. | |
| 700 | 1 | |a Gálvez, G. | |
| 700 | 1 | |a Castro, M.E. | |
| 700 | 1 | |a Rizzo, N. | |
| 700 | 1 | |a Lauricella, A.M. | |
| 700 | 1 | |a Gutnisky, A. | |
| 773 | 0 | |d 1997 |g v. 3 |h pp. 347-351 |k n. 4 |p NEPHROLOGY |x 13205358 |t Nephrology | |
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| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_13205358_v3_n4_p347_Nesse |y Handle |
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