Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice

The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only...

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Autor principal: Buzaleh, A.M
Otros Autores: Del Carmen Batlle, A.M
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: Elsevier Inc. 1996
Acceso en línea:Registro en Scopus
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024 7 |2 cas  |a 5 aminolevulinate synthase, 9037-14-3; enflurane, 13838-16-9; heme, 14875-96-8; isoflurane, 26675-46-7; porphobilinogen deaminase, 9036-47-9, 9074-91-3; porphobilinogen synthase, 9036-37-7 
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100 1 |a Buzaleh, A.M. 
245 1 0 |a Strain and sex differences in the effect of enflurane and isoflurane on heme metabolism in mice 
260 |b Elsevier Inc.  |c 1996 
270 1 0 |m Del Carmen Batlle, A.M.Viamonte 1881, 1056 Buenos Aires, Argentina 
506 |2 openaire  |e Política editorial 
504 |a Battle, A.M.D.C., Porphyrins, porphyrias, cancer and photodynamic therapy - A model for carcinogenesis (1993) J. Photochem. Photobiol. B: Biol, 20, pp. 5-22 
504 |a Brodie, B.B., Reid, W.D., Some pharmacological consequences of species variation in rates of metabolism (1967) Fed. Proc., 26, pp. 1062-1070 
504 |a Buzaleh, A.M., Enriquez De Salamanca, R., Batlle, A.M.D.C., Porphyrinogenic properties of the anesthetic Enflurane (1992) Gen. Pharmac., 23, pp. 665-669 
504 |a Buzaleh, A.M., Enriquez De Salamanca, R., Batlle, A.M.D.C., Administration of the anesthetic Isoflurane to mice: A model for acute intermittent porphyria? (1992) J. Pharmacol. Toxicol. Methods, 28, pp. 191-197 
504 |a Buzaleh, A.M., Vazquez, E.S., Batlle, A.M.D.C., Alterations in fluorinated ether anesthetics effects on heme metabolism following chronic ethanol consumption (1995) Gen. Pharmac., 26, pp. 1425-1429 
504 |a Doss, M., Verspohl, F., The "glucose effect" in acute hepatic porphyrias and in experimental porphyria (1981) Klin. Wochenschr, 59, pp. 727-735 
504 |a Grandchamp, B., De Verneuil, H., Beaumont, C., Chretien, S., Walter, O., Nordmann, Y., Tissue-specific expression of porphobilinogen deaminase. Two isoenzymes from a single gene (1987) Eur. J. Biochem., 162, pp. 105-110 
504 |a Hitt, B.A., Mazze, R.I., Stevens, W.C., White, A., Eger E.I. II, Species, strain, sex and individual differences in Enflurane metabolism (1975) Brit. J. Anaesth., 47, pp. 1157-1161 
504 |a Lowry, O., Rosebrough, N., Farr, A., Randall, R., Protein measurement with the Folin-phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275 
504 |a Mazze, R.I., Cousins, M.J., Kosek, J.C., Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyflurane in rats (1973) J. Pharmacol. Exp. Ther., 184, pp. 481-488 
504 |a Murphy, P.C., Acute intermittent porphyria. The anaesthetic problem and its background (1964) Brit. J. Anaesth., 36, pp. 801-812 
504 |a Quail, A.W., Modern inhalation anaesthetic agents. A review of halothane, isoflurane and enflurane (1989) Med. J. Austr., 150, pp. 95-102 
504 |a Rimington, C., Haem biosynthesis and porphyrias: 50 years in retrospect (1989) J. Clin. Chem. Clin. Biochem., 27, pp. 473-486 
520 3 |a The influence of strain and sex on the effect of enflurane and isoflurane administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males.  |l eng 
593 |a Centro de Investigaciones Sobre P., CONICET-FCEN, UBA, Ciudad Universitaria, Pabellón II, Buenos Aires, Argentina 
593 |a Viamonte 1881 10o A, 1056 Buenos Aires, Argentina 
690 1 0 |a ACUTE INTERMITTENT PORPHYRIA 
690 1 0 |a ENFLURANE 
690 1 0 |a HEME METABOLISM 
690 1 0 |a ISOFLURANE 
690 1 0 |a SEX 
690 1 0 |a STRAIN 
690 1 0 |a 5 AMINOLEVULINATE SYNTHASE 
690 1 0 |a ENFLURANE 
690 1 0 |a HEME 
690 1 0 |a ISOFLURANE 
690 1 0 |a PORPHOBILINOGEN DEAMINASE 
690 1 0 |a PORPHOBILINOGEN SYNTHASE 
690 1 0 |a ACUTE INTERMITTENT PORPHYRIA 
690 1 0 |a ANIMAL EXPERIMENT 
690 1 0 |a ANIMAL MODEL 
690 1 0 |a ARTICLE 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a ENZYME BLOOD LEVEL 
690 1 0 |a FEMALE 
690 1 0 |a HEME SYNTHESIS 
690 1 0 |a INTRAPERITONEAL DRUG ADMINISTRATION 
690 1 0 |a MALE 
690 1 0 |a METABOLISM 
690 1 0 |a MOUSE 
690 1 0 |a NONHUMAN 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a SEX DIFFERENCE 
690 1 0 |a STRAIN DIFFERENCE 
700 1 |a Del Carmen Batlle, A.M. 
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