Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae)
Microcystins are toxins produced by cyanobacteria, being toxic to aquatic fauna. It was evaluated alternative mechanisms of microcystins toxicity, including oxidative stress and histopathology in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae). Microcystins wa...
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2003
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| LEADER | 16575caa a22016217a 4500 | ||
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| 001 | PAPER-4879 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203428.0 | ||
| 008 | 190411s2003 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-1642352609 | |
| 024 | 7 | |2 cas |a catalase, 9001-05-2; glutathione transferase, 50812-37-8; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Bacterial Toxins; Catalase, EC 1.11.1.6; Glutathione Transferase, EC 2.5.1.18; Lipid Peroxides; Melanins; microcystin, 77238-39-2; Microcystins; Peptides, Cyclic; Superoxide Dismutase, EC 1.15.1.1 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a CBPPF | ||
| 100 | 1 | |a Pinho, G.L.L. | |
| 245 | 1 | 0 | |a Toxic effects of microcystins in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae) |
| 260 | |c 2003 | ||
| 270 | 1 | 0 | |m Monserrat, J.M.; Depto. de Cie. Fisiológicas, Fund. Univ. Federal Do Rio Grande, R. Eng Alfredo Huch 475, Rio Grande 96201-900, Brazil; email: jose@octopus.furg.br |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Vinagre, T.M., Alciati, J.C., Yunes, J.S., Bianchini, A., Richards, J., Monserrat, J.M., Effects of extracts from the cyanobacterium Microcystis aeruginosa on ion regulation and gill Na+, K+-ATPase and phosphatase K+ dependent activities of the estuarine crab Chasmagnathus granulata (Decapoda, Grapsidae) (2002) Physiol. Biochem. Zool., 75, pp. 600-608 | ||
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| 504 | |a Xu, L., Lam, P.K.S., Chen, J., Zhang, Y., Harada, K., Comparative study on in vitro inhibition of grass carp (Ctenopharyngodon ideallus) and mouse protein phosphatases by microcystins (2000) Environ. Toxicol., 15, pp. 71-75 | ||
| 504 | |a Zar, J.H., (1984) Biostatistical Analysis, , New Jersey: Prentice Hall | ||
| 520 | 3 | |a Microcystins are toxins produced by cyanobacteria, being toxic to aquatic fauna. It was evaluated alternative mechanisms of microcystins toxicity, including oxidative stress and histopathology in the hepatopancreas of the estuarine crab Chasmagnathus granulatus (Decapoda, Grapsidae). Microcystins was administered to crabs (MIC group) over 1 week, whereas the control (CTR group) received the saline from cyanobacteria culture medium. At day 7, catalase activity was higher in the MIC than in the CTR group, although a decrease of activity was verified in both groups with respect to time 0. Glutathione-S-transferase activity augmented in MIC with respect to CTR, suggesting a higher conjugation rate of the toxins with glutathione. No differences were detected in the superoxide dismutase activity. Lipid peroxidation remained stable in both groups. Histopathological analyses showed that the number of B cells decreased significantly in the CTR as a possible effect of starvation, while no significant change was observed in the MIC group. The hepatopancreas from the MIC group exhibited some necrotic tubules and melanin-like deposits. Overall, results showed that some enzymes of the antioxidant defense system were activated after microcystins exposure, this response being able to maintain lipid peroxidation levels, but insufficient to completely prevent histological damage. © 2003 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, X 222 | ||
| 536 | |a Detalles de la financiación: Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul | ||
| 536 | |a Detalles de la financiación: This research was supported by a grant from FAPERGS (Proc. No. 0021350) to J.M. Monserrat. Cristiane Moura da Rosa is an undergraduate fellow from FAPERGS and Grasiela Lopes Leães Pinho is a graduate fellow from CAPES. A. Bianchini and J.S. Yunes are research fellows of the Brazilian CNPq. C.M. Luquet was supported by the University of Buenos Aires (Grant X 222). | ||
| 593 | |a Depto. de Cie. Fisiológicas, Fund. Univ. Federal Do Rio Grande, R. Eng Alfredo Huch 475, Rio Grande 96201-900, Brazil | ||
| 593 | |a Programa de Pós, Graduacao Em Cie. Fisologicas, Fisiologia Animal Comparada, Brazil | ||
| 593 | |a Unidade Pesquisa Em Cianobacterias, Fund. Univ. Federal Do Rio Grande, Rio Grande 96201-900, Brazil | ||
| 593 | |a Laboratório de Histologia, Fac. de Ciencias Exactas Y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a B CELLS |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a CHASMAGNATHUS GRANULATUS |
| 690 | 1 | 0 | |a ESTUARINE CRAB |
| 690 | 1 | 0 | |a GLUTATHIONE-S-TRANSFERASE |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a MICROCYSTINS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a CYANOGINOSIN |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ANIMAL MODEL |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a B LYMPHOCYTE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CRAB |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a HEPATOPANCREAS |
| 690 | 1 | 0 | |a HISTOPATHOLOGY |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a LIVER TOXICITY |
| 690 | 1 | 0 | |a LYMPHOCYTE COUNT |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MINIMUM INHIBITORY CONCENTRATION |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BACTERIAL TOXINS |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a CYANOBACTERIA |
| 690 | 1 | 0 | |a DECAPODA (CRUSTACEA) |
| 690 | 1 | 0 | |a GLUTATHIONE TRANSFERASE |
| 690 | 1 | 0 | |a HEPATOPANCREAS |
| 690 | 1 | 0 | |a HISTOCYTOCHEMISTRY |
| 690 | 1 | 0 | |a LIPID PEROXIDES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MELANINS |
| 690 | 1 | 0 | |a MICROCYSTINS |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PEPTIDES, CYCLIC |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a CHASMAGNATHUS GRANULATA |
| 690 | 1 | 0 | |a CYANOBACTERIA |
| 690 | 1 | 0 | |a DECAPODA (CRUSTACEA) |
| 690 | 1 | 0 | |a GRAPSIDAE |
| 650 | 1 | 7 | |2 spines |a NECROSIS |
| 700 | 1 | |a Moura Da Rosa, C. | |
| 700 | 1 | |a Yunes, J.S. | |
| 700 | 1 | |a Luquet, C.M. | |
| 700 | 1 | |a Bianchini, A. | |
| 700 | 1 | |a Monserrat, J.M. | |
| 773 | 0 | |d 2003 |g v. 135 |h pp. 459-468 |k n. 4 |p Comp. Biochem. Physiol. C Toxicol. Pharmacol. |x 15320456 |w (AR-BaUEN)CENRE-4256 |t Comparative Biochemistry and Physiology - C Toxicology and Pharmacology | |
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