Transforming growth factor-β stimulates vascular endothelial growth factor production by folliculostellate pituitary cells
TGF-β isoforms are expressed in the anterior pituitary and modulate the growth and function of endocrine pituitary cells. Recently, TGF-β has been shown to stimulate growth and basic fibroblast growth factor secretion in nonendocrine folliculostellate (FS) pituitary cells. We therefore studied wheth...
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2002
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 14506caa a22015257a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5209 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203450.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036773325 | |
| 024 | 7 | |2 cas |a Dexamethasone, 50-02-2; DNA-Binding Proteins; Endothelial Growth Factors; Glucocorticoids; Lymphokines; Madh2 protein, rat; Protein Isoforms; Receptors, Transforming Growth Factor beta; RNA, Messenger; Smad2 Protein; Smad2 protein, mouse; Trans-Activators; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a ENDOA | ||
| 100 | 1 | |a Renner, U. | |
| 245 | 1 | 0 | |a Transforming growth factor-β stimulates vascular endothelial growth factor production by folliculostellate pituitary cells |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Renner, U.; Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstrasse 10, D-80804 Munich, Germany; email: renner@mpipsykl.mpg.de |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a TGF-β isoforms are expressed in the anterior pituitary and modulate the growth and function of endocrine pituitary cells. Recently, TGF-β has been shown to stimulate growth and basic fibroblast growth factor secretion in nonendocrine folliculostellate (FS) pituitary cells. We therefore studied whether the production of FS cell-derived vascular endothelial growth factor (VEGF), the most important regulator of vascular permeability and angiogenesis, is affected by TGF-β. We observed by RT-PCR that TtT/GF cells, which are FS mouse pituitary tumor cells, synthesize TGF-β1, -β2, and -β3. They also express TGF-β receptors types 1 and 2, as well as Smad2, Smad3, and Smad4 proteins, which are essential for TGF-β binding and signaling. Stimulation of TtT/GF cells with either TGF-β1 or TGF-β3 induced a rapid translocation of Smad2 into the cell nuclei. Both TGF-β isoforms dose dependently stimulated VEGF production in TtT/GF cells, but not in lactosomatotroph GH3 cells. Time-course studies and suppression of TGF-β-induced VEGF production by cycloheximide suggest that TGF-β induces de novo synthesis of VEGF in folliculostellate cells, which is completely blocked by dexamethasone. In primary rat pituitary cell cultures, TGF-β and -β3 stimulated VEGF production. TGF-β stimulation of VEGF production by folliculostellate cells could modulate intrapituitary vascular permeability and integrity as well as angiogenesis in an auto-/paracrine manner. |l eng | |
| 593 | |a Max-Planck-Institute of Psychiatry, Munich D-80804, Germany | ||
| 593 | |a Department of Endocrinology, Munich D-80804, Germany | ||
| 593 | |a Laboratorio de Fisiologia y Biologia Molecular, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina | ||
| 593 | |a Department de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina | ||
| 593 | |a Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstrasse 10, D-80804 Munich, Germany | ||
| 690 | 1 | 0 | |a CYCLOHEXIMIDE |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a SMAD2 PROTEIN |
| 690 | 1 | 0 | |a SMAD3 PROTEIN |
| 690 | 1 | 0 | |a SMAD4 PROTEIN |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA RECEPTOR |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA1 |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA2 |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA3 |
| 690 | 1 | 0 | |a VASCULOTROPIN |
| 690 | 1 | 0 | |a ANGIOGENESIS |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BLOOD VESSEL PERMEABILITY |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a HYPOPHYSIS CELL |
| 690 | 1 | 0 | |a HYPOPHYSIS TUMOR |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN ANALYSIS |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN TRANSPORT |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BIOLOGICAL TRANSPORT |
| 690 | 1 | 0 | |a CELL NUCLEUS |
| 690 | 1 | 0 | |a CELLS, CULTURED |
| 690 | 1 | 0 | |a DEXAMETHASONE |
| 690 | 1 | 0 | |a DNA-BINDING PROTEINS |
| 690 | 1 | 0 | |a ENDOTHELIAL GROWTH FACTORS |
| 690 | 1 | 0 | |a GLUCOCORTICOIDS |
| 690 | 1 | 0 | |a LYMPHOKINES |
| 690 | 1 | 0 | |a MALE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a PITUITARY GLAND |
| 690 | 1 | 0 | |a PITUITARY GLAND, ANTERIOR |
| 690 | 1 | 0 | |a PROTEIN ISOFORMS |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, SPRAGUE-DAWLEY |
| 690 | 1 | 0 | |a RECEPTORS, TRANSFORMING GROWTH FACTOR BETA |
| 690 | 1 | 0 | |a RNA, MESSENGER |
| 690 | 1 | 0 | |a SMAD2 PROTEIN |
| 690 | 1 | 0 | |a TRANS-ACTIVATORS |
| 690 | 1 | 0 | |a TRANSFORMING GROWTH FACTOR BETA |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTOR A |
| 690 | 1 | 0 | |a VASCULAR ENDOTHELIAL GROWTH FACTORS |
| 700 | 1 | |a Lohrer, P. | |
| 700 | 1 | |a Schaaf, L. | |
| 700 | 1 | |a Feirer, M. | |
| 700 | 1 | |a Schmitt, K. | |
| 700 | 1 | |a Onofri, C. | |
| 700 | 1 | |a Arzt, E. | |
| 700 | 1 | |a Stalla, G.K. | |
| 773 | 0 | |d 2002 |g v. 143 |h pp. 3759-3765 |k n. 10 |p Endocrinology |x 00137227 |w (AR-BaUEN)CENRE-4573 |t Endocrinology | |
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