Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase
The in vivo effect of the known herbicide, paraquat, on both hepatic oxidative stress and heme metabolism was studied. A marked increase in lipid peroxidation and a decrease in reduced glutathione (GSH) content were observed 1 h after paraquat administration. The activity of liver antioxidant enzyme...
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2002
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| LEADER | 12477caa a22014537a 4500 | ||
|---|---|---|---|
| 001 | PAPER-5337 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203458.0 | ||
| 008 | 190411s2002 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0036605348 | |
| 024 | 7 | |2 cas |a 5-Aminolevulinate Synthetase, EC 2.3.1.37; alpha-Tocopherol, 59-02-9; Antioxidants; Enzymes; Glutathione, 70-18-8; Heme Oxygenase (Decyclizing), EC 1.14.99.3; Heme Oxygenase-1, EC 1.14.99.3; Heme, 14875-96-8; Herbicides; Paraquat, 4685-14-7; Thiobarbituric Acid Reactive Substances | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a FRARE | ||
| 100 | 1 | |a Noriega, G.O. | |
| 245 | 1 | 0 | |a Paraquat-generated oxidative stress in rat liver induces heme oxygenase-1 and aminolevulinic acid synthase |
| 260 | |c 2002 | ||
| 270 | 1 | 0 | |m Tomaro, M.L.; Facultad de Farmacia y Bioquimica, Dept. de Quimica Biológica, Universidad de Buenos, Junín 956, Buenos Aires 1113, Argentina; email: ptomaro@ffyb.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 520 | 3 | |a The in vivo effect of the known herbicide, paraquat, on both hepatic oxidative stress and heme metabolism was studied. A marked increase in lipid peroxidation and a decrease in reduced glutathione (GSH) content were observed 1 h after paraquat administration. The activity of liver antioxidant enzymes, superoxide dismutase, catalase and glutathione peroxidase was decreased 3 h after paraquat injection. Heme oxygenase-1 induction started 9 h after treatment, peaking at 15 h. δ-aminolevulinic acid synthase induction occurred once heme oxygenase had been enhanced, reaching its maximum (1.5-fold of control) at 16 h. δ-aminolevulinic acid dehydratase activity was 40% inhibited at 3 h showing a profile similar to that of GSH, while porphobilinogenase activity was not modified along the whole period of the assay. Administration of α-tocopherol (35 mmol/kg body weight) 2 h before paraquat treatment entirely prevented the increase in thiobarbituric acid reactive substances (TBARS) content, the decrease in GSH levels as well as heme oxygenase-1 and δ-aminolevulinic acid synthase induction. This study shows that oxidative stress produced by paraquat leads to an increase in δ-aminolevulinic acid synthase and heme oxygenase-1 activities, indicating that the herbicide affects both heme biosynthesis and degradation. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: This work was supported by grants from the Universidad de Buenos Aires (Argentina) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) (Argentina). M.L.T. and A.M. del C.B. are career investigators from CONICET. | ||
| 593 | |a Centro de Investigaciones Sobre Porfirinas y Porfirias (CIPYP), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a Facultad de Farmacia y Bioquímica, Departamento de Química Biológica, Universidad de Buenos, Junín 956, Buenos Aires -1113, Argentina | ||
| 690 | 1 | 0 | |a Δ-AMINOLEVULINIC ACID SYNTHASE |
| 690 | 1 | 0 | |a ANTIOXIDANT ENZYMES |
| 690 | 1 | 0 | |a HEME METABOLISM |
| 690 | 1 | 0 | |a HEME OXYGENASE-1 |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PARAQUAT |
| 690 | 1 | 0 | |a 5 AMINOLEVULINATE SYNTHASE |
| 690 | 1 | 0 | |a ALPHA TOCOPHEROL |
| 690 | 1 | 0 | |a ANTIOXIDANT |
| 690 | 1 | 0 | |a CATALASE |
| 690 | 1 | 0 | |a GLUTATHIONE |
| 690 | 1 | 0 | |a GLUTATHIONE PEROXIDASE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HEME OXYGENASE 1 |
| 690 | 1 | 0 | |a HERBICIDE |
| 690 | 1 | 0 | |a LIPID |
| 690 | 1 | 0 | |a LIVER ENZYME |
| 690 | 1 | 0 | |a PARAQUAT |
| 690 | 1 | 0 | |a PORPHOBILINOGEN SYNTHASE |
| 690 | 1 | 0 | |a SUPEROXIDE DISMUTASE |
| 690 | 1 | 0 | |a THIOBARBITURIC ACID REACTIVE SUBSTANCE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BIOSYNTHESIS |
| 690 | 1 | 0 | |a BODY WEIGHT |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DEGRADATION |
| 690 | 1 | 0 | |a ENZYME ACTIVITY |
| 690 | 1 | 0 | |a ENZYME ASSAY |
| 690 | 1 | 0 | |a ENZYME INHIBITION |
| 690 | 1 | 0 | |a IN VIVO STUDY |
| 690 | 1 | 0 | |a LIPID PEROXIDATION |
| 690 | 1 | 0 | |a LIVER METABOLISM |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PORPHYRIN METABOLISM |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a 5-AMINOLEVULINATE SYNTHETASE |
| 690 | 1 | 0 | |a ALPHA-TOCOPHEROL |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIOXIDANTS |
| 690 | 1 | 0 | |a ENZYMES |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GLUTATHIONE |
| 690 | 1 | 0 | |a HEME |
| 690 | 1 | 0 | |a HEME OXYGENASE (DECYCLIZING) |
| 690 | 1 | 0 | |a HEME OXYGENASE-1 |
| 690 | 1 | 0 | |a HERBICIDES |
| 690 | 1 | 0 | |a LIVER |
| 690 | 1 | 0 | |a OXIDATIVE STRESS |
| 690 | 1 | 0 | |a PARAQUAT |
| 690 | 1 | 0 | |a RATS |
| 690 | 1 | 0 | |a RATS, WISTAR |
| 690 | 1 | 0 | |a THIOBARBITURIC ACID REACTIVE SUBSTANCES |
| 700 | 1 | |a Gonzales, S. | |
| 700 | 1 | |a Tomaro, M.L. | |
| 700 | 1 | |a Del, A.M. | |
| 700 | 1 | |a Batlle, C. | |
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