Current status and progress made in malaria chemotherapy

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Malaria is the most important parasitic disease worldwide, affecting more than 500 million people and causing close to 1 million deaths per annum. This serious fact is mainly attributable to the emergence of drug resistant strains of Plasmodium falciparum. The advances made in malaria chemotherapy b...

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Detalles Bibliográficos
Autor principal: Liñares, G.E.G
Otros Autores: Rodriguez, J.B
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2007
Materias:
MALARIA
Acceso en línea:Registro en Scopus
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Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-33847190634 
024 7 |2 cas  |a amodiaquine, 69-44-3, 86-42-0; artemisinin, 63968-64-9; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; cysteine proteinase, 37353-41-6; dihydroartemisinin, 71939-50-9, 81496-81-3; dihydrofolate reductase, 9002-03-3; heme, 14875-96-8; hemoglobin, 9008-02-0; mefloquine, 51773-92-3, 53230-10-7; mepacrine, 69-05-6, 83-89-6; proteinase, 9001-92-7; pyrimethamine, 53640-38-3, 58-14-0; pyronaridine, 74847-35-1; quinine, 130-89-2, 130-95-0, 14358-44-2, 549-48-4, 549-49-5, 60-93-5, 7549-43-1; glutathione, 70-18-8; glutathione transferase, 50812-37-8; hemozoin, 39404-00-7; thioredoxin, 52500-60-4; transferase, 9047-61-4; Alkyl and Aryl Transferases, 2.5.-; Antimalarials; Artemisinins; Cysteine Endopeptidases, 3.4.22.-; Cysteine Proteinase Inhibitors; Fatty Acids; Glutathione, 70-18-8; Glutathione Transferase, 2.5.1.18; Hemeproteins; Polyamines; Sesquiterpenes; Thioredoxin, 52500-60-4; artemisinine, 63968-64-9; falcipain, 3.4.22.-; hemozoin, 39404-00-7; p21(ras) farnesyl-protein transferase, 2.5.1.- 
040 |a Scopus  |b spa  |c AR-BaUEN  |d AR-BaUEN 
030 |a CMCHE 
100 1 |a Liñares, G.E.G. 
245 1 0 |a Current status and progress made in malaria chemotherapy 
260 |c 2007 
270 1 0 |m Rodriguez, J.B.; Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, C1428EHA Buenos Aires, Argentina; email: JBR@qo.fcen.uba.ar 
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520 3 |a Malaria is the most important parasitic disease worldwide, affecting more than 500 million people and causing close to 1 million deaths per annum. This serious fact is mainly attributable to the emergence of drug resistant strains of Plasmodium falciparum. The advances made in malaria chemotherapy based on unique aspects of the biochemistry and physiology of the responsible agents for this disease, parasites of Plasmodium genus, are covered in this review. Increasing resistance to conventional antimalarial drugs constitutes the main drawback for the persistence of this disease. In the present article, a comprehensive analysis of selected molecular targets is depicted in terms of their potential utility as chemotherapeutic agents. Our review focuses on different and important molecular targets for drug design that include proteases that hydrolyze hemoglobin, protein farnesyltransferase, heme detoxification pathway, polyamine pathways, dihydrofolate reductase, artemisinin-based combination therapies (ACTs), etc. Therefore, rational approaches to control malaria targeting metabolic pathways of malaria parasites which are essential for parasites survival are presented. © 2007 Bentham Science Publishers Ltd.  |l eng 
593 |a Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, C1428EHA Buenos Aires, Argentina 
690 1 0 |a CHLOROQUINE 
690 1 0 |a CYSTEINE PROTEASES 
690 1 0 |a FARNESYLTRANSFERASE INHIBITORS 
690 1 0 |a PIPERAZINE DERIVATIVES 
690 1 0 |a PLASMODIUM FALCIPARUM 
690 1 0 |a 4 AMINOQUINOLINE DERIVATIVE 
690 1 0 |a AMINOBENZENESULFONAMIDE DERIVATIVE 
690 1 0 |a AMINOPHENOL DERIVATIVE 
690 1 0 |a AMODIAQUINE 
690 1 0 |a ANTIMALARIAL AGENT 
690 1 0 |a ARTEMISININ 
690 1 0 |a ARTEMISININ DERIVATIVE 
690 1 0 |a ARTEMISONE 
690 1 0 |a CHLOROQUINE 
690 1 0 |a CYSTEINE PROTEINASE 
690 1 0 |a DIHYDROARTEMISININ 
690 1 0 |a DIHYDROFOLATE REDUCTASE 
690 1 0 |a FALCIPAIN INHIBITOR 
690 1 0 |a FATTY ACID 
690 1 0 |a FATTY ACID SYNTHASE INHIBITOR 
690 1 0 |a HEME 
690 1 0 |a HEMOGLOBIN 
690 1 0 |a MEFLOQUINE 
690 1 0 |a MEPACRINE 
690 1 0 |a METHYLPIPERAZINE DERIVATIVE 
690 1 0 |a POLYAMINE 
690 1 0 |a PROTEIN FARNESYLTRANSFERASE 
690 1 0 |a PROTEINASE 
690 1 0 |a PYRIMETHAMINE 
690 1 0 |a PYRONARIDINE 
690 1 0 |a QUININE 
690 1 0 |a QUINOLINE DERIVATIVE 
690 1 0 |a SULFONAMIDE 
690 1 0 |a THIOACRIDONE DERIVATIVE 
690 1 0 |a UNCLASSIFIED DRUG 
690 1 0 |a UNINDEXED DRUG 
690 1 0 |a ANTIMALARIAL AGENT 
690 1 0 |a ARTEMISININ 
690 1 0 |a ARTEMISININ DERIVATIVE 
690 1 0 |a CYSTEINE PROTEINASE 
690 1 0 |a CYSTEINE PROTEINASE INHIBITOR 
690 1 0 |a FALCIPAIN 
690 1 0 |a FATTY ACID 
690 1 0 |a GLUTATHIONE 
690 1 0 |a GLUTATHIONE TRANSFERASE 
690 1 0 |a HEMOPROTEIN 
690 1 0 |a HEMOZOIN 
690 1 0 |a P21(RAS) FARNESYL PROTEIN TRANSFERASE 
690 1 0 |a P21(RAS) FARNESYL-PROTEIN TRANSFERASE 
690 1 0 |a POLYAMINE 
690 1 0 |a SESQUITERPENE 
690 1 0 |a THIOREDOXIN 
690 1 0 |a TRANSFERASE 
690 1 0 |a ANTIMALARIAL ACTIVITY 
690 1 0 |a BIOCHEMISTRY 
690 1 0 |a CHEMOTHERAPY 
690 1 0 |a DRUG BIOAVAILABILITY 
690 1 0 |a DRUG DESIGN 
690 1 0 |a DRUG HALF LIFE 
690 1 0 |a DRUG POTENCY 
690 1 0 |a DRUG POTENTIATION 
690 1 0 |a DRUG STRUCTURE 
690 1 0 |a HUMAN 
690 1 0 |a IC 50 
690 1 0 |a IN VITRO STUDY 
690 1 0 |a IN VIVO STUDY 
690 1 0 |a MALARIA CONTROL 
690 1 0 |a MALARIA FALCIPARUM 
690 1 0 |a NEUROTOXICITY 
690 1 0 |a NONHUMAN 
690 1 0 |a PARASITE SURVIVAL 
690 1 0 |a PARASITOSIS 
690 1 0 |a PLASMODIUM FALCIPARUM 
690 1 0 |a REVIEW 
690 1 0 |a STRUCTURE ACTIVITY RELATION 
690 1 0 |a ANIMAL 
690 1 0 |a BIOSYNTHESIS 
690 1 0 |a DRUG ANTAGONISM 
690 1 0 |a DRUG EFFECT 
690 1 0 |a DRUG RESISTANCE 
690 1 0 |a METABOLISM 
690 1 0 |a PHYSIOLOGY 
690 1 0 |a ALKYL AND ARYL TRANSFERASES 
690 1 0 |a ANIMALS 
690 1 0 |a ANTIMALARIALS 
690 1 0 |a ARTEMISININS 
690 1 0 |a CYSTEINE ENDOPEPTIDASES 
690 1 0 |a CYSTEINE PROTEINASE INHIBITORS 
690 1 0 |a DRUG RESISTANCE 
690 1 0 |a FATTY ACIDS 
690 1 0 |a GLUTATHIONE 
690 1 0 |a GLUTATHIONE TRANSFERASE 
690 1 0 |a HEMEPROTEINS 
690 1 0 |a HUMANS 
690 1 0 |a PLASMODIUM FALCIPARUM 
690 1 0 |a POLYAMINES 
690 1 0 |a SESQUITERPENES 
690 1 0 |a STRUCTURE-ACTIVITY RELATIONSHIP 
690 1 0 |a THIOREDOXIN 
650 1 7 |2 spines  |a MALARIA 
650 1 7 |2 spines  |a MALARIA 
700 1 |a Rodriguez, J.B. 
773 0 |d 2007  |g v. 14  |h pp. 289-314  |k n. 3  |p Curr. Med. Chem.  |x 09298673  |t Current Medicinal Chemistry 
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856 4 0 |u https://doi.org/10.2174/092986707779941096  |y DOI 
856 4 0 |u https://hdl.handle.net/20.500.12110/paper_09298673_v14_n3_p289_Linares  |y Handle 
856 4 0 |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v14_n3_p289_Linares  |y Registro en la Biblioteca Digital 
961 |a paper_09298673_v14_n3_p289_Linares  |b paper  |c PE 
962 |a info:eu-repo/semantics/article  |a info:ar-repo/semantics/artículo  |b info:eu-repo/semantics/publishedVersion 
999 |c 67697 

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