1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties
We have reported the isolation of the tetranortriterpenoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) from partially purified leaf extracts of Melia azedarach L. (MA) that reduced both, vesicular stomatitis virus (VSV) and Herpes simplex virus type 1 (HSV-1) multiplication. CDM blocks VSV entry and...
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2006
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 10542caa a22014057a 4500 | ||
|---|---|---|---|
| 001 | PAPER-7142 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203653.0 | ||
| 008 | 190411s2006 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-33745270082 | |
| 024 | 7 | |2 cas |a 1-cinnamoyl-3,11-dihydroxymeliacarpin; Antiviral Agents; Limonins; NF-kappa B | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BBRCA | ||
| 100 | 1 | |a Barquero, A.A. | |
| 245 | 1 | 0 | |a 1-Cinnamoyl-3,11-dihydroxymeliacarpin is a natural bioactive compound with antiviral and nuclear factor-κB modulating properties |
| 260 | |c 2006 | ||
| 270 | 1 | 0 | |m Barquero, A.A.; Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellon II, Piso 4to., Ciudad Univ., C1428BGA Buenos Aires, Argentina; email: alecab@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Haridas, V., Arntzen, C., Gutterman, J., Avicins, a family of triterpenoids saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-κB by inhibiting both its nuclear localization and ability to bind DNA (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 11557-11562 | ||
| 504 | |a Jung, H., Nam, J., Choi, J., Lee, K., Park, H., 19 Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa (2005) Biol. Pharm. Bull., 28, pp. 101-104 | ||
| 504 | |a Battinelli, L., Mengoni, F., Lichtner, M., Mazzanti, G., Saija, A., Mastroianni, C., Vullo, V., Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells (2003) Planta Med., 69, pp. 910-913 | ||
| 504 | |a Ikeda, T., Yokomizo, K., Okawa, M., Tsuchihashi, R., Kinjo, J., Nohara, T., Uyeda, M., Anti-herpes virus type 1 activity of oleanane-type triterpenoids (2005) Biol. Pharm. Bull., 28, pp. 1779-1781 | ||
| 504 | |a Alché, L., Assad Ferek, G., Meo, M., Coto, C., Maier, M., An antiviral meliacarpin from leaves of Melia azedarach L. (2003) Z. Naturforsch. Sect. C, 58 c (3-4), pp. 215-219 | ||
| 504 | |a Barquero, A., Alché, L., Coto, C., Block of VSV endocytic and exocytic pathways by 1-cinnamoyl-3,11-dihydroxymeliacarpin, a tetranortriterpenoid of natural origin (2004) J. Gen. Virol., 85, pp. 483-493 | ||
| 504 | |a Pifarré, M., Berra, A., Coto, C., Alché, L., Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice (2002) Exp. Eye Res., 75, pp. 327-334 | ||
| 504 | |a Hiscott, J., Kwon, H., Genin, P., Hostile takeovers: viral appropriation of the NF-kappaB pathway (2001) J. Clin. Invest., 107, pp. 143-151 | ||
| 504 | |a Diebold, Y., Calonge, M., Enriquez de Salamanca, A., Callejo, S., Corrales, R., Saez, V., Siemasko, K., Stern, M., Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva (2003) Invest. Ophthalmol. Vis. Sci., 44, pp. 4263-4274 | ||
| 504 | |a Giraudo, C., Daniotti, J., Maccioni, H., Physical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus (2001) Proc. Natl. Acad. Sci. USA, 98, pp. 1625-1630 | ||
| 504 | |a Michelini, F., Ramírez, J., Berra, A., Galagovsky, L., Alché, L., In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues (2004) Steroids, 69, pp. 713-720 | ||
| 504 | |a Gregory, D., Hargett, D., Holmes, D., Money, E., Bachenheimer, S., Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway (2004) J. Virol., 78, pp. 13582-13590 | ||
| 504 | |a Vermani, K., Garg, S., Herbal medicines for sexually transmitted diseases and AIDS (2002) J. Ethnopharmacol., 80, pp. 49-66 | ||
| 504 | |a Alché, L., Barquero, A., Sanjuan, N., Coto, C., An antiviral principle present in a purified fraction from Melia azedarach L. leaf aqueous extract restrains Herpes simplex virus type 1 propagation (2002) Phytother. Res., 16, pp. 348-352 | ||
| 504 | |a Wachsman, M., Castilla, V., Coto, C., Inhibition of foot and mouth disease virus (FMDV) uncoating by a plant-derived peptide isolated from Melia azedarach L. leaves (1998) Arch. Virol., 143, pp. 581-590 | ||
| 504 | |a Castilla, V., Barquero, A., Mersich, S., Coto, C., In vitro anti-Junín virus activity of a peptide isolated from Melia azedarach L. leaves (1998) Int. J. Antimicrob. Agents, 10, pp. 67-75 | ||
| 504 | |a Nicola, A., Straus, S., Cellular and viral requirements for rapid endocytic entry of herpes simplex virus (2004) J. Virol., 78, pp. 7508-7517 | ||
| 504 | |a Leuzinger, H., Ziegler, U., Schraner, E., Fraefel, C., Glauser, D., Heid, I., Ackermann, M., Wild, P., Herpes simplex virus 1 envelopment follows two diverse pathways (2005) J. Virol., 79, pp. 13047-13059 | ||
| 504 | |a Ludwig, S., Planz, O., Pleschka, S., Wolff, T., Influenza-virus-induced signaling cascades: targets for antiviral therapy? (2003) Trends Mol. Med., 9, pp. 46-52 | ||
| 504 | |a Santoro, M., Rossi, A., Amici, C., NF-kappaB and virus infection: who controls whom (2003) EMBO J., 22, pp. 2552-2560 | ||
| 504 | |a Amici, C., Belardo, G., Rossi, A., Santoro, M., Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for anti-herpetic therapy (2001) J. Biol. Chem., 276, pp. 28759-28766 | ||
| 504 | |a Bremner, P., Heinrich, M., Natural products as targeted modulators of the nuclear factor-kappaB pathway (2002) J. Pharm. Pharmacol., 54, pp. 453-472 | ||
| 520 | 3 | |a We have reported the isolation of the tetranortriterpenoid 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM) from partially purified leaf extracts of Melia azedarach L. (MA) that reduced both, vesicular stomatitis virus (VSV) and Herpes simplex virus type 1 (HSV-1) multiplication. CDM blocks VSV entry and the intracellular transport of VSV-G protein, confining it to the Golgi apparatus, by pre- or post-treatment, respectively. Here, we report that HSV-1 glycoproteins were also confined to the Golgi apparatus independently of the nature of the host cell. Considering that MA could be acting as an immunomodulator preventing the development of herpetic stromal keratitis in mice, we also examined an eventual effect of CDM on NF-κB signaling pathway. CDM is able to impede NF-κB activation in HSV-1-infected conjunctival cells and leads to the accumulation of p65 NF-κB subunit in the cytoplasm of uninfected treated Vero cells. In conclusion, CDM is a pleiotropic agent that not only inhibits the multiplication of DNA and RNA viruses by the same mechanism of action but also modulates the NF-κB signaling pathway. © 2006 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires, UBA X-046 | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica, PICT 12343 | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, PIP 6033/05 | ||
| 536 | |a Detalles de la financiación: The authors thank Isabel Paz and Guillermo Assad Ferek for their technical assistance, and Roux-Ocefa laboratory for the liophilization of leaf extracts. This work was supported by grants from the University of Buenos Aires (UBA X-046), Agencia Nacional de Promoción Científica y Técnica (ANPCyT) (PICT 12343), and CONICET (PIP 6033/05). | ||
| 593 | |a Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellon II, Piso 4to., Ciudad Univ., C1428BGA Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a 1-CINNAMOYL-3,11-DIHYDROXYMELIACARPIN |
| 690 | 1 | 0 | |a ANTIINFLAMMATORY |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS TYPE 1 |
| 690 | 1 | 0 | |a MELIA AZEDARACH L. |
| 690 | 1 | 0 | |a NATURAL ANTIVIRAL |
| 690 | 1 | 0 | |a NF-ΚB |
| 690 | 1 | 0 | |a TRITERPENOIDS |
| 690 | 1 | 0 | |a 1 CINNAMOYL 3,11 DIHYDROXYMELIACARPIN |
| 690 | 1 | 0 | |a ANTIVIRUS AGENT |
| 690 | 1 | 0 | |a TERPENOID DERIVATIVE |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a 1 CINNAMOYL 3,11 DIHYDROXYMELIACARPIN |
| 690 | 1 | 0 | |a 1-CINNAMOYL-3,11-DIHYDROXYMELIACARPIN |
| 690 | 1 | 0 | |a ANTIVIRUS AGENT |
| 690 | 1 | 0 | |a IMMUNOGLOBULIN ENHANCER BINDING PROTEIN |
| 690 | 1 | 0 | |a LIMONOID |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA REPLICATION |
| 690 | 1 | 0 | |a DNA VIRUS |
| 690 | 1 | 0 | |a GOLGI COMPLEX |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS |
| 690 | 1 | 0 | |a HOST CELL |
| 690 | 1 | 0 | |a IMMUNOMODULATION |
| 690 | 1 | 0 | |a MEMBRANE TRANSPORT |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PURIFICATION |
| 690 | 1 | 0 | |a RNA REPLICATION |
| 690 | 1 | 0 | |a RNA VIRUS |
| 690 | 1 | 0 | |a VESICULAR STOMATITIS VIRUS |
| 690 | 1 | 0 | |a VIROGENESIS |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CERCOPITHECUS |
| 690 | 1 | 0 | |a CONJUNCTIVA |
| 690 | 1 | 0 | |a DOSE RESPONSE |
| 690 | 1 | 0 | |a DRUG EFFECT |
| 690 | 1 | 0 | |a GROWTH, DEVELOPMENT AND AGING |
| 690 | 1 | 0 | |a HERPES SIMPLEX VIRUS 1 |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a METABOLISM |
| 690 | 1 | 0 | |a PHYSIOLOGY |
| 690 | 1 | 0 | |a VERO CELL |
| 690 | 1 | 0 | |a VIROLOGY |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 690 | 1 | 0 | |a HUMAN HERPESVIRUS 1 |
| 690 | 1 | 0 | |a MELIA AZEDARACH |
| 690 | 1 | 0 | |a RNA VIRUSES |
| 690 | 1 | 0 | |a VESICULAR STOMATITIS VIRUS |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a ANTIVIRAL AGENTS |
| 690 | 1 | 0 | |a CELL LINE |
| 690 | 1 | 0 | |a CERCOPITHECUS AETHIOPS |
| 690 | 1 | 0 | |a CONJUNCTIVA |
| 690 | 1 | 0 | |a DOSE-RESPONSE RELATIONSHIP, DRUG |
| 690 | 1 | 0 | |a HERPESVIRUS 1, HUMAN |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LIMONINS |
| 690 | 1 | 0 | |a NF-KAPPA B |
| 690 | 1 | 0 | |a VERO CELLS |
| 690 | 1 | 0 | |a VIRUS REPLICATION |
| 700 | 1 | |a Michelini, F.M. | |
| 700 | 1 | |a Alché, L.E. | |
| 773 | 0 | |d 2006 |g v. 344 |h pp. 955-962 |k n. 3 |p Biochem. Biophys. Res. Commun. |x 0006291X |w (AR-BaUEN)CENRE-905 |t Biochemical and Biophysical Research Communications | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bbrc.2006.03.226 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_0006291X_v344_n3_p955_Barquero |y Handle |
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