Interferon-γ Inhibits Metalloproteinase Activity and Cytotrophoblast Cell Migration

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Problem Establishment of a successful pregnancy relies on a complex fetal-mother communication that starts with the embryo adhering and invading the endometrium. This requires remodeling of extracellular matrix, performed by metalloproteinases. Cytokines, such as interferon-γ (IFN-γ), play a role in...

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Detalles Bibliográficos
Autor principal: Fontana, V.A
Otros Autores: Sanchez, M., Cebral, E., Calvo, J.C
Formato: Capítulo de libro
Lenguaje:Inglés
Publicado: 2010
Materias:
PLACENTA
Acceso en línea:Registro en Scopus
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Aporte de:Registro referencial: Solicitar el recurso aquí
Biblioteca Central Dr. Luis F. Leloir (FCEN) de Universidad de Buenos Aires
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024 7 |2 scopus  |a 2-s2.0-77955978946 
024 7 |2 cas  |a gamma interferon, 82115-62-6; gelatinase, 9040-48-6; gelatinase A, 146480-35-5; gelatinase B, 146480-36-6; metalloproteinase, 81669-70-7; Interferon-gamma, 82115-62-6; Leptin; Matrix Metalloproteinase 2, 3.4.24.24; Matrix Metalloproteinase 9, 3.4.24.35 
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030 |a AAJID 
100 1 |a Fontana, V.A. 
245 1 0 |a Interferon-γ Inhibits Metalloproteinase Activity and Cytotrophoblast Cell Migration 
260 |c 2010 
270 1 0 |m Calvo, J.C.; Instituto de Biología y Medicina Experimental, Vuelta de Obligado 2490, Buenos Aires, Argentina; email: jcalvo@dna.uba.ar 
506 |2 openaire  |e Política editorial 
504 |a Das, R.M., Martin, L., Uterine DNA synthesis and cell proliferation during early decidualization induced by oil in mice (1978) J Reprod Fertil, 53, pp. 125-128 
504 |a Lejeune, B., Van Hoeck, J., Leroy, F., Satellite versus total DNA replication in relation to endopolyploidy of decidual cells in the mouse (1982) Chromosoma, 84, pp. 511-516 
504 |a Stewart, I., Peel, S., The differentiation of the decidua and the distribution of metrial gland cells in the pregnant mouse uterus (1978) Cell Tissue Res, 187, pp. 167-179 
504 |a Mukhtar, D.D., Stewart, I.J., Croy, B.A., Leucocyte membrane antigens on mouse granulated metrial gland cells (1989) J Reprod Immunol, 15, pp. 269-279 
504 |a Linnemeyer, P.A., Pollack, S.B., Murine granulated metrial gland cells at uterine implantation sites are natural killer lineage cells (1991) J Immunol, 147, pp. 2530-2535 
504 |a Parr, E.L., Parr, M.B., Zheng, L.M., Young, J., Mouse granulated metrial gland cells originate by local activation of uterine natural killer lymphocytes (1991) Biol Reprod, 44, pp. 834-841 
504 |a Ashkar, A.A., Di Santo, J.P., Croy, B.A., Interferon- contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy (2000) J Exp Med, 192, pp. 259-270 
504 |a Chantakru, S., Miller, C., Roach, L.E., Kuziel, W.A., Maeda, N., Wang, W.C., Evans, S.S., Croy, B.A., Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy (2002) J Immunol, 168, pp. 22-28 
504 |a Billington, W.D., The immunological problem of pregnancy: 50 years with the hope of progress. A tribute to Peter Medawar (2003) J Reprod Immunol, 60, pp. 1-11 
504 |a Cameo, M., Fontana, V., Cameo, P., Vauthay, L.G., Kaplan, J., Tesone, M., Similar embryotoxic effects of sera from infertile patients and exogenous interferon-γ on long-term in-vitro development of mouse embryos (1999) Hum Reprod, 14, pp. 959-963 
504 |a Fontana, V., Choren, V., Vauthay, L., Calvo, J.C., Calvo, L., Cameo, M., Exogenous interferon-γ alters murine inner cell mass and trophoblast development. Effect on the expression of ErbB1, ErbB4 and heparan sulfate proteoglycan (perlecan) (2004) Reproduction, 128, pp. 717-725 
520 3 |a Problem Establishment of a successful pregnancy relies on a complex fetal-mother communication that starts with the embryo adhering and invading the endometrium. This requires remodeling of extracellular matrix, performed by metalloproteinases. Cytokines, such as interferon-γ (IFN-γ), play a role in implantation and could affect the success of pregnancy.Method of study Using JEG-3 cell line as model, we cultured the cells in the presence or absence of IFN-γ and determined the activities of MMP-2 and MMP-9 using zymography and the secretion of leptin using Western blot.Results Interferon-γ inhibits gelatinase activity from MMP-2 and MMP-9 in a dose-dependent manner, reducing the secretion of leptin (not because of a general inhibition on protein synthesis) and impairs cell migration on Matrigel.Conclusion Our results correlate with previous reports from our laboratory indicating that IFN- γ is deleterious for mouse embryo outgrowth, having an effect on metalloproteinases activity as well as leptin secretion. © 2010 John Wiley & Sons A/S.  |l eng 
593 |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a Laboratorio de Biología del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias, DBBE,Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina 
593 |a Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina 
690 1 0 |a CYTOKINES 
690 1 0 |a EXTRACELLULAR MATRIX 
690 1 0 |a GAMMA INTERFERON 
690 1 0 |a GELATINASE 
690 1 0 |a GELATINASE A 
690 1 0 |a GELATINASE B 
690 1 0 |a LEPTIN 
690 1 0 |a METALLOPROTEINASE 
690 1 0 |a GAMMA INTERFERON 
690 1 0 |a GELATINASE A 
690 1 0 |a GELATINASE B 
690 1 0 |a LEPTIN 
690 1 0 |a ARTICLE 
690 1 0 |a CELL CULTURE 
690 1 0 |a CELL MIGRATION 
690 1 0 |a CELL STRAIN JEG 3 
690 1 0 |a CONTROLLED STUDY 
690 1 0 |a CYTOTROPHOBLAST 
690 1 0 |a ENZYME ACTIVITY 
690 1 0 |a FEMALE 
690 1 0 |a HUMAN 
690 1 0 |a HUMAN CELL 
690 1 0 |a HUMAN CELL CULTURE 
690 1 0 |a PREGNANCY 
690 1 0 |a PRIORITY JOURNAL 
690 1 0 |a PROTEIN SYNTHESIS 
690 1 0 |a WESTERN BLOTTING 
690 1 0 |a ZYMOGRAPHY 
690 1 0 |a ANIMAL 
690 1 0 |a BIOSYNTHESIS 
690 1 0 |a CELL MOTION 
690 1 0 |a DRUG EFFECT 
690 1 0 |a ENZYMOLOGY 
690 1 0 |a METABOLISM 
690 1 0 |a MOUSE 
690 1 0 |a PHYSIOLOGY 
690 1 0 |a POLYACRYLAMIDE GEL ELECTROPHORESIS 
690 1 0 |a TROPHOBLAST 
690 1 0 |a TUMOR CELL LINE 
690 1 0 |a ANIMALS 
690 1 0 |a BLOTTING, WESTERN 
690 1 0 |a CELL LINE, TUMOR 
690 1 0 |a CELL MOVEMENT 
690 1 0 |a ELECTROPHORESIS, POLYACRYLAMIDE GEL 
690 1 0 |a FEMALE 
690 1 0 |a HUMANS 
690 1 0 |a INTERFERON-GAMMA 
690 1 0 |a LEPTIN 
690 1 0 |a MATRIX METALLOPROTEINASE 2 
690 1 0 |a MATRIX METALLOPROTEINASE 9 
690 1 0 |a MICE 
690 1 0 |a TROPHOBLASTS 
650 1 7 |2 spines  |a PLACENTA 
700 1 |a Sanchez, M. 
700 1 |a Cebral, E. 
700 1 |a Calvo, J.C. 
773 0 |d 2010  |g v. 64  |h pp. 20-26  |k n. 1  |p Am. J. Reprod. Immunol.  |x 10467408  |w (AR-BaUEN)CENRE-3647  |t American Journal of Reproductive Immunology 
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856 4 0 |u https://doi.org/10.1111/j.1600-0897.2010.00816.x  |y DOI 
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999 |c 68749 

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