Pathogenicity in mice of Staphylococcus aureus mutants deficient in exoprotein synthesis
Twelve mutants were isolated from a Staphylococcus aureus strain derived from bovine mastitis after mutagenesis by ultraviolet light. These mutants were found to be deficient for several characteristics such as production of most exoproteins and had altered phage type and/or colonial morphology in s...
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| Otros Autores: | , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
1994
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 04584caa a22008297a 4500 | ||
|---|---|---|---|
| 001 | PAPER-81 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518202928.0 | ||
| 008 | 140217s1994 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-0028094670 | |
| 024 | 7 | |2 pubmed |a 7975150 | |
| 024 | 7 | |2 cas |a Hemolysins; Mannitol, 69-65-8 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a VMICD | ||
| 100 | 1 | |a Odierno, L. | |
| 245 | 1 | 0 | |a Pathogenicity in mice of Staphylococcus aureus mutants deficient in exoprotein synthesis |
| 260 | |c 1994 | ||
| 270 | 1 | 0 | |m Nagel, R.; Facultad Ciencias Exactas/Naturales, Universidad de Buenos Aires, CEFYBO-CONICET, Serrano 665, (1414) Capital Federal, Buenos Aires, Argentina |
| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a Twelve mutants were isolated from a Staphylococcus aureus strain derived from bovine mastitis after mutagenesis by ultraviolet light. These mutants were found to be deficient for several characteristics such as production of most exoproteins and had altered phage type and/or colonial morphology in serum-soft agar medium. They also differed in virulence when assayed in mice by intraperitoneal administration; the ratio of the LD 50 of the mutants vs. that of the parental strain ranged from 1 to 123. The different virulence of the mutants could not be associated with lack of production of exoproteins or altered colonial morphology. On the other hand, a clear correlation was evidenced between lowered virulence and slower growth rate at 37°C. Three mutants were assayed in the mouse mastitis model. One of them, which was about 40 times less virulent when assayed by intraperitoneal administration, induced a histopathological lesion similar to that produced by the parent strain; the other two mutants, which were about 70 to 120 times less virulent by intraperitoneal administration, induced only a very slight lesion. Mice were vaccinated by the intraperitoneal route with two of the less virulent mutants; the LD 50 in the vaccinated mice that were challenged with the parental strain increased 11 to 14 times compared with that for the unvaccinated mice. |l eng | |
| 593 | |a Departamento de Microbiología, Facultad de Ciencias Exactas, Físico, Químicas y Naturales, Universidad Nacional de Río Cuarto, Córdoba, Argentina | ||
| 593 | |a Departamento de Patología Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Córdoba, Argentina | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires y CEFYBO-CONICET, Serrano 665, (1414) Capital Federal, Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BACTERIAL |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a MUTANT |
| 690 | 1 | 0 | |a PATHOGENICITY |
| 690 | 1 | 0 | |a STAPHYLOCOCCUS AEUREUS |
| 690 | 1 | 0 | |a BACTERIAL VACCINE |
| 690 | 1 | 0 | |a ANIMAL EXPERIMENT |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a BACTERIAL VIRULENCE |
| 690 | 1 | 0 | |a BACTERIUM MUTANT |
| 690 | 1 | 0 | |a CATTLE DISEASE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PATHOGENICITY |
| 690 | 1 | 0 | |a PROVOCATION TEST |
| 690 | 1 | 0 | |a STAPHYLOCOCCUS AUREUS |
| 690 | 1 | 0 | |a VACCINATION |
| 690 | 1 | 0 | |a ANIMAL |
| 690 | 1 | 0 | |a CATTLE |
| 690 | 1 | 0 | |a HEMOLYSINS |
| 690 | 1 | 0 | |a MANNITOL |
| 690 | 1 | 0 | |a MASTITIS |
| 690 | 1 | 0 | |a MASTITIS, BOVINE |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MUTATION |
| 690 | 1 | 0 | |a STAPHYLOCOCCUS AUREUS |
| 690 | 1 | 0 | |a SUPPORT, NON-U.S. GOV'T |
| 690 | 1 | 0 | |a VIRULENCE |
| 690 | 1 | 0 | |a ANIMALIA |
| 690 | 1 | 0 | |a BACTERIA (MICROORGANISMS) |
| 690 | 1 | 0 | |a BOS TAURUS |
| 690 | 1 | 0 | |a BOVINAE |
| 690 | 1 | 0 | |a STAPHYLOCOCCUS |
| 690 | 1 | 0 | |a STAPHYLOCOCCUS AUREUS |
| 700 | 1 | |a Risatti, G. | |
| 700 | 1 | |a Calzolari, A. | |
| 700 | 1 | |a Giraudo, J.A. | |
| 700 | 1 | |a Quintana, H.G. | |
| 700 | 1 | |a Nagel, R. | |
| 773 | 0 | |d 1994 |g v. 41 |h pp. 249-258 |k n. 3 |p VET. MICROBIOL. |x 03781135 |w (AR-BaUEN)CENRE-7123 |t Veterinary Microbiology | |
| 856 | 4 | 1 | |u http://www.scopus.com/inward/record.url?eid=2-s2.0-0028094670&partnerID=40&md5=ccc5abfa7b4bf4b68e8b7161cedb919f |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/0378-1135(94)90105-8 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_03781135_v41_n3_p249_Odierno |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03781135_v41_n3_p249_Odierno |y Registro en la Biblioteca Digital |
| 961 | |a paper_03781135_v41_n3_p249_Odierno |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 999 | |c 61034 | ||