The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target?
Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons. In return, the central nervous system provides feedback and modulates the afferent stream of information through efferent neurons. The medial oliv...
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2009
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| LEADER | 30493caa a22026177a 4500 | ||
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| 001 | PAPER-8470 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230607131853.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-68349137966 | |
| 024 | 7 | |2 cas |a ebselen, 60940-34-3; neramexane, 209185-99-9, 219810-59-0, 457068-92-7; ondansetron, 103639-04-9, 116002-70-1, 99614-01-4; tropisetron, 89565-68-4; Acetylcholine, 51-84-3; Protein Subunits; Receptors, Nicotinic | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BCPCA | ||
| 100 | 1 | |a Elgoyhen, A.B. | |
| 245 | 1 | 4 | |a The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Elgoyhen, A.B.; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, 1428, Argentina; email: elgoyhen@dna.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
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| 504 | |a Bertrand, D., Gopalakrishnan, M., Allosteric modulation of nicotinic acetylcholine receptors (2007) Biochem Pharmacol, 74, pp. 1155-1163 | ||
| 504 | |a Hurst, R.S., Hajos, M., Raggenbass, M., Wall, T.M., Higdon, N.R., Lawson, J.A., A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization (2005) J Neurosci, 25, pp. 4396-4405 | ||
| 504 | |a Zorrilla de San Martin, J., Ballestero, J., Katz, E., Elgoyhen, A.B., Fuchs, P.A., Ryanodine is a positive modulator of acetylcholine receptor gating in cochlear hair cells (2007) J Assoc Res Otolaryngol, 8, pp. 474-483 | ||
| 504 | |a Rothlin, C.V., Lioudyno, M.I., Silbering, A.F., Plazas, P.V., Casati, M.E., Katz, E., Direct interaction of serotonin type 3 receptor ligands with recombinant and native alpha 9 alpha 10-containing nicotinic cholinergic receptors (2003) Mol Pharmacol, 63, pp. 1067-1074 | ||
| 520 | 3 | |a Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons. In return, the central nervous system provides feedback and modulates the afferent stream of information through efferent neurons. The medial olivocochlear efferent system makes direct synaptic contacts with outer hair cells and inhibits amplification brought about by the active mechanical process inherent to these cells. This feedback system offers the potential to improve the detection of signals in background noise, to selectively attend to particular signals, and to protect the periphery from damage caused by overly loud sounds. Acetylcholine released at the synapse between efferent terminals and outer hair cells activates a peculiar nicotinic cholinergic receptor subtype, the α9α10 receptor. At present no pharmacotherapeutic approaches have been designed that target this cholinergic receptor to treat pathologies of the auditory system. The potential use of α9α10 selective drugs in conditions such as noise-induced hearing loss, tinnitus and auditory processing disorders is discussed. © 2009 Elsevier Inc. All rights reserved. |l eng | |
| 536 | |a Detalles de la financiación: National Institute on Deafness and Other Communication Disorders, R01DC001508 | ||
| 536 | |a Detalles de la financiación: Universidad de Buenos Aires | ||
| 536 | |a Detalles de la financiación: Howard Hughes Medical Institute | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: ABE, EK and PAF are supported by the National Institutes of Deafness and other Communication Disorders (NIDCD) Grant R01DC001508. ABE is supported by an International Research Scholar Grant from the Howard Hughes Medical Institute, the Tinnitus Research Initiative, Research Grants from ANPCyT (Argentina) and the University of Buenos Aires (Argentina). EK is supported by Research Grants from the University of Buenos Aires (Argentina) and CONICET (Argentina). | ||
| 593 | |a Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, 1428, Argentina | ||
| 593 | |a Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, 1121, Argentina | ||
| 593 | |a Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, 1428, Argentina | ||
| 593 | |a Department of Otolaryngology, Head and Neck Surgery, the Center for Hearing and Balance, Center for Sensory Biology, Baltimore, MD 21205-2195, United States | ||
| 690 | 1 | 0 | |a COCHLEA |
| 690 | 1 | 0 | |a EFFERENT FEEDBACK |
| 690 | 1 | 0 | |a NICOTINIC CHOLINERGIC RECEPTORS |
| 690 | 1 | 0 | |a NOISE TRAUMA |
| 690 | 1 | 0 | |a TINNITUS |
| 690 | 1 | 0 | |a AM 111 |
| 690 | 1 | 0 | |a CHOLINESTERASE INHIBITOR |
| 690 | 1 | 0 | |a EBSELEN |
| 690 | 1 | 0 | |a NERAMEXANE |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR ALPHA9ALPHA10 |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR ALPHA9ALPHA10 AGONIST |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR ALPHA9ALPHA10 ANTAGONIST |
| 690 | 1 | 0 | |a NICOTINIC RECEPTOR ALPHA9ALPHA10 MODULATOR |
| 690 | 1 | 0 | |a ONDANSETRON |
| 690 | 1 | 0 | |a PNU 120596 |
| 690 | 1 | 0 | |a TROPISETRON |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a CLINICAL TRIAL |
| 690 | 1 | 0 | |a COCHLEA |
| 690 | 1 | 0 | |a CORTI ORGAN |
| 690 | 1 | 0 | |a DRUG DESIGN |
| 690 | 1 | 0 | |a DRUG EFFICACY |
| 690 | 1 | 0 | |a DRUG SAFETY |
| 690 | 1 | 0 | |a EFFERENT NERVE |
| 690 | 1 | 0 | |a FEEDBACK SYSTEM |
| 690 | 1 | 0 | |a HAIR CELL |
| 690 | 1 | 0 | |a HEARING LOSS |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HYPOACUSIS |
| 690 | 1 | 0 | |a MENIERE DISEASE |
| 690 | 1 | 0 | |a NEUROTRANSMITTER RELEASE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a OTITIS MEDIA |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a PROTEIN TARGETING |
| 690 | 1 | 0 | |a RECEPTOR BLOCKING |
| 690 | 1 | 0 | |a REVIEW |
| 690 | 1 | 0 | |a SYNAPTIC TRANSMISSION |
| 690 | 1 | 0 | |a TINNITUS |
| 690 | 1 | 0 | |a ACETYLCHOLINE |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a AUDITORY PERCEPTUAL DISORDERS |
| 690 | 1 | 0 | |a COCHLEA |
| 690 | 1 | 0 | |a DYSLEXIA |
| 690 | 1 | 0 | |a HAIR CELLS, AUDITORY |
| 690 | 1 | 0 | |a HEARING LOSS |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a NOISE |
| 690 | 1 | 0 | |a OLIVARY NUCLEUS |
| 690 | 1 | 0 | |a PROTEIN SUBUNITS |
| 690 | 1 | 0 | |a RECEPTORS, NICOTINIC |
| 690 | 1 | 0 | |a SYNAPTIC TRANSMISSION |
| 690 | 1 | 0 | |a TINNITUS |
| 653 | 0 | 0 | |a am 111, Auris; pnu 120596 |
| 700 | 1 | |a Katz, E. | |
| 700 | 1 | |a Fuchs, P.A. | |
| 773 | 0 | |d 2009 |g v. 78 |h pp. 712-719 |k n. 7 |p Biochem. Pharmacol. |x 00062952 |w (AR-BaUEN)CENRE-914 |t Biochemical Pharmacology | |
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| 856 | 4 | 0 | |u https://doi.org/10.1016/j.bcp.2009.05.023 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00062952_v78_n7_p712_Elgoyhen |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v78_n7_p712_Elgoyhen |y Registro en la Biblioteca Digital |
| 961 | |a paper_00062952_v78_n7_p712_Elgoyhen |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 69423 | ||