Evaluation of genotoxic biomarkers in extracts of marine sponges from Argentinean South Sea
Marine sponges are a rich source of structurally and biologically active metabolites of biomedical importance. We screened polar and non-polar samples of crude extracts obtained from marine sponges collected in different locations of Argentinean south sea coast, as a novel approach for their charact...
Guardado en:
| Autor principal: | |
|---|---|
| Otros Autores: | , , , , , , , , |
| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
| Publicado: |
2009
|
| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
| Aporte de: | Registro referencial: Solicitar el recurso aquí |
| LEADER | 12530caa a22011897a 4500 | ||
|---|---|---|---|
| 001 | PAPER-8916 | ||
| 003 | AR-BaUEN | ||
| 005 | 20230518203846.0 | ||
| 008 | 190411s2009 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-59049104698 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a JEMBA | ||
| 100 | 1 | |a Bartolotta, S.A. | |
| 245 | 1 | 0 | |a Evaluation of genotoxic biomarkers in extracts of marine sponges from Argentinean South Sea |
| 260 | |c 2009 | ||
| 270 | 1 | 0 | |m Carballo, M.A.; GIGETOX, Citogenética Humana y Genética Toxicológica, INFIBIOC, Junín 956, (1113), Buenos Aires, Argentina; email: macarballo2003@yahoo.com.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Aiub, C., Giannerini, A., Ferreira, F., Mazzei, J., Stankevicins, L., Lobo-Hajdu, G., Guimaraes, P., Felzenszwalb, I., Genotoxic evaluation of extracts from Aplysina fulva, a Brazilian marine sponge (2002) Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 611 (1-2), pp. c34-c41 | ||
| 504 | |a Becerro, M.A., Paul, V.J., Starmer, J., Intracolonial variation in chemical defenses of the sponge Cacospongia sp. and its consequences on the generalist fish predator and the specialist nudibranch predator Glossodoris pallida (1998) Journal of Marine Ecology. Prog Ser, 168, pp. 187-196 | ||
| 504 | |a Becerro, M.A., Thacker, R.W., Turon, X., Uriz, M.J., Paul, V., Biogeography of sponge chemical ecology: comparisons of tropical and temperate defenses (2003) Oecologia, 135, pp. 91-101 | ||
| 504 | |a Bergmann, W., Feeney, R.J., The isolation of a new thymine pentoside from sponges (1950) Journal of the American Chemical Society, 72, pp. 2809-2810 | ||
| 504 | |a Bergmann, W., Feeney, R.J., Contributions to the study of marine products. XXXII. The nucleosides of sponges (1951) Journal of Organic Chemistry, 16, pp. 981-987 | ||
| 504 | |a Bjarnason, I., Hayllar, J., Macpherson, A.J., Russel, A.S., Side effects of nonsteroidal antiinflammatory drugs on the small and large intestine in humans (1993) Gastroenterology, 104, pp. 1832-1847 | ||
| 504 | |a Borchard, U., Pharmacological properties of ß adrenoreceptor blocking drugs (1998) Journal of Clinical and Basic Cardiology, 1, pp. 5-9 | ||
| 504 | |a De Rosa, S., Mediterranean marine organisms as source of new potential drugs (2002) Natural products in the new Millennium: Prospects and Industrial Applications, pp. 441-461. , Rauter A., Palma F.B., Justino J., Araujo M.E., and Santos S.P. (Eds), Kluwer Academic Publishers, The Netherlands | ||
| 504 | |a Faulkner, D.J., Marine natural products (2000) Journal of Natural Products Rep., 17, pp. 7-55 | ||
| 504 | |a Grandjean, P., Biomarkers in epidemiology (1995) Clinical Chemistry, 41-12, pp. 1800-1803 | ||
| 504 | |a Harvell, C.D., Fenical, W., Roussis, V., Ruesink, J.L., Griggs, C.C., Greene, C.H., Local and geographic variation in the defensive chemistry of a West Indian gorgonian coral (Briareum asbestinum) (1993) Journal of Marine Ecology. Prog Ser, 93, pp. 165-173 | ||
| 504 | |a Hay, M.E., Fenical, W., Chemical ecology and marine biodiversity: insights and products from the sea (1996) Oceanography (Wash), 9, pp. 10-20 | ||
| 504 | |a López Gappa, J., Landoni, N., Biodiversity of Porifera in the southwest Atlantic between 35° S y 56° S (2005) Revista del Museo Argentino de Ciencias Naturales n.s., 7 (2), pp. 191-219 | ||
| 504 | |a Miller, B.M., Adler, I.D., Suspect spindle poisons: analysis of c-mitotic effects in mouse bone (1989) Mutagenesis, 4, pp. 208-221 | ||
| 504 | |a Monks, N.R., Lerner, C., Henriques, A.T., Farias, F.M., Schapoval, E.S.S., Suyenaga, E.S., Rocha, A.B., Mothes, B., Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, Southern Brazil (2002) Journal of Experimental Marine Biology and Ecology, 281, pp. 1-12 | ||
| 504 | |a Muehlbauer, P.A., Schuler, M.J., Measuring the mitotic index in chemically treated human lymphocytes cultures by flow cytometry (2003) Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 537 (2), pp. 117-130 | ||
| 504 | |a Natarajan, A.T., Chromosome aberrations: past, present and future (2002) Mutation Research, 504 (1-2), pp. 3-16 | ||
| 504 | |a OECD, OECD Guidelines for the testing of chemicals No. 474: Genetic toxicology: mammalian erythrocyte micronucleus test (1997) Organisation for Economic Cooperation and Development, Paris | ||
| 504 | |a Olivier, S.R., Elementos de Ecología (1971) Ed.Hemisferio Sur., pp. 114-115 | ||
| 504 | |a Palermo, J.A., Rodríguez, M.F., Seldes, A.M., Storniamides A-D: alkaloids from a Patagonian sponge Cliona sp (1996) Tetrahedron, 52, pp. 2727-2734 | ||
| 504 | |a Palermo, J.A., Rodríguez, M.F., Cabezas, E., Balzaretti, V., Seldes, A.M., "Celenamide E, a tripeptide alkaloid from the patagonian sponge Cliona chilensis" (1998) Journal of Natural Products, 61, pp. 488-490 | ||
| 504 | |a Perry, P., Wolff, S., New Giemsa method for differential staining of sister chromatids (1974) Nature (London), 261, pp. 156-161 | ||
| 504 | |a Prado, M., 2002. Study of antiproliferative action of extracts of marine organisms. Doctoral thesis in Biology. Institute of Biomedics Sciences. University of Sao Paulo, Brazil. 87 pp; Proksch, P., Edrada, R.A., Ebel, R., Drugs from the sea - current status and microbiological implications (2002) Applied Microbiology and Biotechnology, 59, pp. 125-134 | ||
| 504 | |a Proksch, P., Ebel, R., Edrada, R., Schupp, P., Lin Sudarsono, W., Wray, V., Steube, K., Detection of pharmacologically active natural products using ecology (2003) Pure and Applied Chemistry, 75 (2-3), pp. 343-352 | ||
| 504 | |a Rahden-Staron, I., The inhibitory effect of the fungicides captan and captafol on eukaryotes topoisomerases in vitro and lack of recombinagenic activity in the wing spot test of Drosophila melanogaster (2002) Mutation Research, 518, pp. 205-213 | ||
| 504 | |a Rangel, M., De Sanctis, B., Freitas, J.C., Moutinho Polatto, J., Granato, A.C., Berlinck, R.G.S., Hajdu, E., Cytotoxic and neurotoxic activities in extract of marine sponges (Prefer) from southeastern Brazilian coast (2001) Journal of Experimental Marine Ecology, 262, pp. 31-40 | ||
| 504 | |a Rifai, S., Fassouane, A., Pinho, E., Kijjoa, A., Nazareth, N., Nascimento, M., Herz, W., Cytotoxicity and Inhibition of Lymphocyte Proliferation of Fasciculatin, a Linear Furanosesterterpene Isolated from Ircinia variabilis Collected from the Atlantic Coast of Morocco (2005) Marine Drugs, 3, pp. 15-21 | ||
| 504 | |a Rojas, E., Herrera, L.A., Sordo, M., Gonsebatt, M.E., Montero, R., Rodriguez, R., Ostrosky-Wegman, P., Mitotic index and cell proliferation kinetics for the identification of antineoplastic activity (1993) Anticancer Drugs, 4, pp. 637-640 | ||
| 504 | |a Scuteri, Marta A., 2002. Cytotoxic effects in CHO cells of the alkylpiperidinics alkaloids arenosclerins A-C and haliclonacyclamine E isolated from the marine sponge Arenosclera brasiliensis. Doctoral thesis in Toxicology. Faculty of Pharmacological Sciences. University of Sao Paulo, Brazil. 91 pp; Sipkema, D., 2004. Cultivation of Marine Sponge : From Sea to Cell. Ph D thesis. Wageningen University. The Netherlands; Tennant, R.W., Margolin, B.H., Shelby, M.D., Zeiger, E., Haseman, J.K., Spalding, J., Caspary, W., Minor, R., Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays (1987) Science, 236, pp. 933-941 | ||
| 504 | |a Torres, Y.R., Berlinck, R.G.S., Nascimento, G.G., Fortier, S.C., Pessoa, C., Moraes, M.O., Antibacterial activity against resistant bacteria and cytotoxicity of four alkaloid toxins isolated from the marine sponge Arenosclera brasiliensis (2002) Toxicon, 40, pp. 885-891 | ||
| 504 | |a Tucker, J.D., Preston, R.J., Chromosome aberrations, micronuclei, aneuploidy, sister chromatid exchanges, and cancer risk assessment (1996) Mutation Research, 365, pp. 147-159 | ||
| 504 | |a Zuleta, I.A., Vitelli, M.A., Baggio, R., Garland, M.T., Seldes, A.M., Palermo, J.A., Novel pteridine alkaloids from the sponge Clathria sp (2002) Tetrahedron, 58, pp. 4481-4486 | ||
| 520 | 3 | |a Marine sponges are a rich source of structurally and biologically active metabolites of biomedical importance. We screened polar and non-polar samples of crude extracts obtained from marine sponges collected in different locations of Argentinean south sea coast, as a novel approach for their characterization. The evaluation was performed using cytotoxic and genotoxic biomarkers such as mitotic index (MI), cell proliferation kinetics (CPK) and sister chromatid exchanges (SCE), monitored in vitro using peripheral blood lymphocytes. Statistical analysis was performed using two-way analysis of variance (ANOVA). The extracts evaluated belonged to: Callyspongia flabellata (BURTON, 1932) (Callyspongiidae); Plicatellopsis sp.(Suberitidae); Callyspongia fortis (RIDLEY, 1881) (Callyspongiidae); Clathria (Microciona) antarctica (TOPSENT, 1917) (Microcionidae); Spongia (Spongia) magellanica (THIELE, 1905) (Spongiidae); Halicnemia papillosa (THIELE, 1905) (Axinellidae); Cliona chilensis (THIELE, 1905) (Clionidae); Haliclona sp. 1; Haliclona sp. 2(Chalinidae). Genotoxicity studies revealed that the evaluated sponge extracts did not exhibit cytotoxic activity measured from mitotic index MI and cell proliferation kinetics(CPK). In contrast, sister chromatid exchanges (SCE) showed that the non-polar extract of Callyspongia fortis and the polar extract of Cliona chilensis presented significant differences in SCE frequency (p < 0.001), when compared with control cultures. These results emphasize the need to set up a standard battery of "in vitro" genotoxicity testing for new chemicals, pharmaceutical and drugs. © 2008 Elsevier B.V. All rights reserved. |l eng | |
| 593 | |a GIGETOX, Citogenética Humana y Genética Toxicológica, INFIBIOC, Junín 956, (1113), Buenos Aires, Argentina | ||
| 593 | |a Departamento de Tecnología, Universidad Nacional de Luján, Ruta 5 y 7. , Luján, 6700 Buenos Aires, Argentina | ||
| 593 | |a UMYMFOR - Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellon II, 1428 Buenos Aires, Argentina | ||
| 593 | |a Museu Nacional, UFRJ, Quinta da Boa Vista, s/n, 20940-040, Rio de Janeiro, RJ, Brazil | ||
| 593 | |a Laboratório de Poríferos Marinhos, Museu de Ciências Naturais Fundação Zoobotânica do Rio Grande do Sul, Brazil. Rua Salvador Franca 1427, 90690-000 Porto Alegre, RS, Brazil | ||
| 690 | 1 | 0 | |a CELL PROLIFERATION KINETICS |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a MARINE SPONGES |
| 690 | 1 | 0 | |a MITOTIC INDEX |
| 690 | 1 | 0 | |a SISTER CHROMATID EXCHANGE |
| 690 | 1 | 0 | |a ANIMAL PRODUCT |
| 690 | 1 | 0 | |a BIOMARKER |
| 690 | 1 | 0 | |a DRUG |
| 690 | 1 | 0 | |a GENOTOXICITY |
| 690 | 1 | 0 | |a MARINE ECOSYSTEM |
| 690 | 1 | 0 | |a METABOLITE |
| 690 | 1 | 0 | |a SPONGE |
| 690 | 1 | 0 | |a TOXICITY TEST |
| 690 | 1 | 0 | |a VARIANCE ANALYSIS |
| 690 | 1 | 0 | |a AXINELLIDAE |
| 690 | 1 | 0 | |a CALLYSPONGIA |
| 690 | 1 | 0 | |a CALLYSPONGIIDAE |
| 690 | 1 | 0 | |a CHALINIDAE |
| 690 | 1 | 0 | |a CLATHRIA |
| 690 | 1 | 0 | |a CLIONA |
| 690 | 1 | 0 | |a HALICLONA |
| 690 | 1 | 0 | |a HALICLONA SP. |
| 690 | 1 | 0 | |a HALICNEMIA |
| 690 | 1 | 0 | |a MICROCIONA |
| 690 | 1 | 0 | |a MICROCIONIDAE |
| 690 | 1 | 0 | |a SPONGIA |
| 690 | 1 | 0 | |a SPONGIIDAE |
| 690 | 1 | 0 | |a SUBERITIDAE |
| 700 | 1 | |a Scuteri, M.A. | |
| 700 | 1 | |a Hick, A.S. | |
| 700 | 1 | |a Palermo, J. | |
| 700 | 1 | |a Rodriguez Brasco, M.F. | |
| 700 | 1 | |a Hajdu, E. | |
| 700 | 1 | |a Mothes, B. | |
| 700 | 1 | |a Lerner, C. | |
| 700 | 1 | |a Campos, M. | |
| 700 | 1 | |a Carballo, M.A. | |
| 773 | 0 | |d 2009 |g v. 369 |h pp. 144-147 |k n. 2 |p J. Exp. Mar. Biol. Ecol. |x 00220981 |w (AR-BaUEN)CENRE-5572 |t Journal of Experimental Marine Biology and Ecology | |
| 856 | 4 | 1 | |u https://www.scopus.com/inward/record.uri?eid=2-s2.0-59049104698&doi=10.1016%2fj.jembe.2008.11.008&partnerID=40&md5=9d874c68ad4c301c044bb8790b5356b6 |y Registro en Scopus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jembe.2008.11.008 |y DOI |
| 856 | 4 | 0 | |u https://hdl.handle.net/20.500.12110/paper_00220981_v369_n2_p144_Bartolotta |y Handle |
| 856 | 4 | 0 | |u https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00220981_v369_n2_p144_Bartolotta |y Registro en la Biblioteca Digital |
| 961 | |a paper_00220981_v369_n2_p144_Bartolotta |b paper |c PE | ||
| 962 | |a info:eu-repo/semantics/article |a info:ar-repo/semantics/artículo |b info:eu-repo/semantics/publishedVersion | ||
| 963 | |a VARI | ||
| 999 | |c 69869 | ||