Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein
Tristetraprolin (TTP) is a RNA-binding protein that inhibits the expression of pro-inflammatory cytokines and invasiveness-associated genes. TTP levels are decreased in many different cancer types and it has been proposed that this protein could be used as a prognostic factor in breast cancer. Here,...
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| Formato: | Capítulo de libro |
| Lenguaje: | Inglés |
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2012
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| Acceso en línea: | Registro en Scopus DOI Handle Registro en la Biblioteca Digital |
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| LEADER | 17358caa a22017057a 4500 | ||
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| 003 | AR-BaUEN | ||
| 005 | 20230518203912.0 | ||
| 008 | 190411s2012 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84866534415 | |
| 024 | 7 | |2 cas |a STAT5a protein, 176744-10-8; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Prolactin, 9002-62-4; STAT5 Transcription Factor; STAT5A protein, human; Tristetraprolin; Tumor Suppressor Proteins; ZFP36 protein, human; Zfp36 protein, mouse | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 030 | |a BCTRD | ||
| 100 | 1 | |a Goddio, M.V. | |
| 245 | 1 | 0 | |a Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m Kordon, E.C.; Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, CM1, Pabellón 2, 2do piso, 1428 Ciudad Autónoma de Buenos Aires, Argentina; email: ekordon@qb.fcen.uba.ar |
| 506 | |2 openaire |e Política editorial | ||
| 504 | |a Chen, C.Y.A., Shyu, A.B., AU-rich elements: Characterization and importance in mRNA degradation (1995) Trends Biochem Sci, 20, pp. 465-470 | ||
| 504 | |a Guhaniyogi, J., Brewer, G., Regulation of mRNA stability in mammalian cells (2001) Gene, 265 (1-2), pp. 11-23. , DOI 10.1016/S0378-1119(01)00350-X, PII S037811190100350X | ||
| 504 | |a Barreau, C., Paillard, L., Osborne, H.B., AU-rich elements and associated factors: Are there unifying principles? (2005) Nucleic Acids Research, 33 (22), pp. 7138-7150. , DOI 10.1093/nar/gki1012 | ||
| 504 | |a Taylor, G.A., Carballo, E., Lee, D.M., Lai, W.S., Thompson, M.J., Patel, D.D., Schenkman, D.I., Blackshear, P.J., A pathogenetic role for TNFα in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency (1996) Immunity, 4 (5), pp. 445-454. , DOI 10.1016/S1074-7613(00)80411-2 | ||
| 504 | |a Smoak, K., Cidlowski, J.A., Glucocorticoids regulate tristetraprolin synthesis and posttranscriptionally regulate tumor necrosis factor alpha inflammatory signaling (2006) Molecular and Cellular Biology, 26 (23), pp. 9126-9135. , DOI 10.1128/MCB.00679-06 | ||
| 504 | |a Ishmael, F.T., Fang, X., Galdiero, M.R., Atasoy, U., Rigby, W.F., Gorospe, M., Cheadle, C., Stellato, C., Role of the RNAbinding protein tristetraprolin in glucocorticoid-mediated gene regulation (2008) J Immunol, 180, pp. 8342-8353 | ||
| 504 | |a Brennan, S., Kuwano, Y., Alkharouf, N., Blackshear, P.J., Gorospe, M., Wilson, G.M., The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis (2009) Cancer Res, 69, pp. 5168-5176 | ||
| 504 | |a Griseri, P., Bourcier, C., Hieblot, C., Essafi-Benkhadir, K., Chamorey, E., Touriol, C., Pagès, G., A synonymous polymorphism of the Tristetraprolin (TTP) gene, an AU-rich mRNA-binding protein, affects translation efficiency and response to Herceptin treatment in breast cancer patients (2011) Hum Mol Genet, 20, pp. 4556-4568 | ||
| 504 | |a Al-Souhibani, N., Al-Ahmadi, W., Hesketh, J.E., Blackshear, P.J., Khabar, K.S.A., The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes (2010) Oncogene, 29, pp. 1-11 | ||
| 504 | |a Reichardt, H.M., Horsch, K., Grone, H.-J., Kolbus, A., Beug, H., Hynes, N., Schutz, G., Mammary gland development and lactation are controlled by different glucocorticoid receptor activities (2001) European Journal of Endocrinology, 145 (4), pp. 519-527 | ||
| 504 | |a Strange, R., Li, F., Saurer, S., Burkhardt, A., Friis, R.R., Apoptotic cell death and tissue remodelling during mouse mammary gland involution (1992) Development, 115, pp. 49-58 | ||
| 504 | |a Pensa, S., Watson, C.J., Poli, V., Stat3 and the inflammation/ acute phase response in involution and breast cancer (2009) J Mammary Gland Biol Neoplasia, 14, pp. 121-129 | ||
| 504 | |a Lyons, T.R., Schedin, P.J., Borges, V.F., Pregnancy and breast cancer: When they collide (2009) J Mammary Gland Biol Neoplasia, 14, pp. 87-98 | ||
| 504 | |a Streuli, C.H., Extracellular matrix and gene expression in mammary epithelium (1993) Semin Cell Biol, 4, pp. 203-212 | ||
| 504 | |a Lin, C.Q., Bissell, M.J., Multi-faceted regulation of cell differentiation by extracellular matrix (1993) FASEB Journal, 7 (9), pp. 737-743 | ||
| 504 | |a Danielson, K.G., Oborn, C.J., Durban, E.M., Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro (1984) Proceedings of the National Academy of Sciences of the United States of America, 81 (12), pp. 3756-3760 | ||
| 504 | |a Chammas, R., Taverna, D., Cella, N., Santos, C., Hynes, N.E., Laminin and tenascin assembly and expression regulate HC11 mouse mammary cell differentiation (1994) Journal of Cell Science, 107 (4), pp. 1031-1040 | ||
| 504 | |a Van De Vijver, M.J., He, Y.D., Van 'T Veer, L.J., Dai, H., Hart, A.A.M., Voskuil, D.W., Schreiber, G.J., Bernards, R., A gene-expression signature as a predictor of survival in breast cancer (2002) New England Journal of Medicine, 347 (25), pp. 1999-2009. , DOI 10.1056/NEJMoa021967 | ||
| 504 | |a Fan, C., Oh, D.S., Wessels, L., Weigelt, B., Nuyten, D.S.A., Nobel, A.B., Van't Veer, L.J., Perou, C.M., Concordance among gene-expression-based predictors for breast cancer (2006) New England Journal of Medicine, 355 (6), pp. 560-569. , http://content.nejm.org/cgi/reprint/355/6/560.pdf, DOI 10.1056/NEJMoa052933 | ||
| 504 | |a Abba, M.C., Sun, H., Hawkins, K.A., Drake, J.A., Hu, Y., Nunez, M.I., Gaddis, S., Aldaz, C.M., Breast cancer molecular signatures as determined by SAGE: Correlation with lymph node status (2007) Molecular Cancer Research, 5 (9), pp. 881-890. , http://mcr.aacrjournals.org/cgi/reprint/5/9/881, DOI 10.1158/1541-7786.MCR-07-0055 | ||
| 504 | |a Anderson, S.M., Rudolph, M.C., McManaman, J.L., Neville, M.C., Key stages in mammary gland development. Secretory activation in the mammary gland: It's not just about milk protein synthesis! (2007) Breast Cancer Res, 9, p. 204 | ||
| 504 | |a Curino, A.C., Engelholm, L.H., Yamada, S.S., Holmbeck, K., Lund, L.R., Molinolo, A.A., Behrendt, N., Bugge, T.H., Intracellular collagen degradation mediated by uPARAP/Endo180 is a major pathway of extracellular matrix turnover during malignancy (2005) Journal of Cell Biology, 169 (6), pp. 977-985. , http://www.jcb.org/cgi/reprint/169/6/977, DOI 10.1083/jcb.200411153 | ||
| 504 | |a Buggiano, V., Schere Levy, C., Gattelli, A., Cecilia Cirio, M., Marfil, M., Nepomnaschy, I., Piazzon, I., Kordon, E.C., Origin and progression of pregnancy-dependent mammary tumors induced by new mouse mammary tumor virus variants (2002) Breast Cancer Research and Treatment, 75 (3), pp. 191-202. , DOI 10.1023/A:1019932516887 | ||
| 504 | |a Dexter, D.L., Kowalski, H.M., Blazar, B.A., Heterogeneity of tumor cells from a single mouse mammary tumor (1978) Cancer Research, 38 (10), pp. 3174-3181 | ||
| 504 | |a Beuvink, I., Hess, D., Flotow, H., Hofsteenge, J., Groner, B., Hynes, N.E., Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity (2000) Journal of Biological Chemistry, 275 (14), pp. 10247-10255. , DOI 10.1074/jbc.275.14.10247 | ||
| 504 | |a Moriggl, R., Gouilleux-Gruart, V., Jahne, R., Berchtold, S., Gartmann, C., Liu, X., Hennighausen, L., Gouilleux, F., Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype (1996) Molecular and Cellular Biology, 16 (10), pp. 5691-5700 | ||
| 504 | |a Bertucci, P.Y., Quaglino, A., Pozzi, A.G., Kordon, E.C., Pecci, A., Glucocorticoid-induced impairment of mammary gland involution is associated with STAT5 and STAT3 signaling modulation (2010) Endocrinology, 151, pp. 5730-5740 | ||
| 504 | |a Sorlie, T., Perou, C.M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Borresen-Dale, A.-L., Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (19), pp. 10869-10874. , DOI 10.1073/pnas.191367098 | ||
| 504 | |a Lonning, P.E., Sorlie, T., Perou, C.M., Brown, P.O., Botstein, D., Borresen-Dale, A.-L., Microarrays in primary breast cancer - Lessons from chemotherapy studies (2001) Endocrine-Related Cancer, 8 (3), pp. 259-263. , DOI 10.1677/erc.0.0080259 | ||
| 504 | |a Elston, C.W., Ellis, I.O., Pathological prognostic factors in breast cancer (1991) I. The Value of Histological Grade in Breast Cancer: Experience from A Large Study with Long-term Follow-up. Histopathology, 19, pp. 403-410 | ||
| 504 | |a Ormandy, C.J., Naylor, M., Harris, J., Robertson, F., Horseman, N.D., Lindeman, G.J., Visvader, J., Kelly, P.A., Investigation of the Transcriptional Changes Underlying Functional Defects in the Mammary Glands of Prolactin Receptor Knockout Mice (2003) Recent Progress in Hormone Research, 58, pp. 297-323. , DOI 10.1210/rp.58.1.297 | ||
| 504 | |a Watson, C.J., Burdon, T.G., Prolactin signal transduction mechanisms in the mammary gland: The role of the Jak/Stat pathway (1996) Rev Reprod, 1, pp. 1-5 | ||
| 504 | |a Barnstein, B.O., Li, G., Wang, Z., Kennedy, S., Chalfant, C., Nakajima, H., Bunting, K.D., Ryan, J.J., Stat5 expression is required for IgE-mediated mast cell function (2006) Journal of Immunology, 177 (5), pp. 3421-3426 | ||
| 504 | |a Suzuki, K., Nakajima, H., Ikeda, K., Maezawa, Y., Suto, A., Takatori, H., Saito, Y., Iwamoto, I., IL-4-Stat6 Signaling Induces Tristetraprolin Expression and Inhibits TNF-α Production in Mast Cells (2003) Journal of Experimental Medicine, 198 (11), pp. 1717-1727. , DOI 10.1084/jem.20031701 | ||
| 504 | |a Joe, Y., Kim, H.J., Kim, S., Chung, J., Ko, M.S., Lee, W.H., Chang, K.C., Chung, H.T., Tristetraprolin mediates antiinflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages (2011) J Biol Chem, 286, pp. 24735-24742 | ||
| 504 | |a Dubois, R.N., McLane, M.W., Ryder, K., Lau, L.F., Nathans, D., A growth factor-inducible nuclear protein with a novel cysteine/ histidine repetitive sequence (1990) J Biol Chem, 265, pp. 19185-19191 | ||
| 504 | |a Lai, W.S., Stumpo, D.J., Blackshear, P.J., Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein (1990) J Biol Chem, 265, pp. 16556-16563 | ||
| 504 | |a Mittelstadt, P.R., Defranco, A., Induction of early response genes by cross-linking membrane Ig on B lymphocytes (2003) J Immunol, 150, pp. 4822-4832 | ||
| 504 | |a Ogawa, K., Chen, F., Kim, Y.-J., Chen, Y., Transcriptional regulation of tristetraprolin by transforming growth factor-β in human T cells (2003) Journal of Biological Chemistry, 278 (32), pp. 30373-30381. , DOI 10.1074/jbc.M304856200 | ||
| 520 | 3 | |a Tristetraprolin (TTP) is a RNA-binding protein that inhibits the expression of pro-inflammatory cytokines and invasiveness-associated genes. TTP levels are decreased in many different cancer types and it has been proposed that this protein could be used as a prognostic factor in breast cancer. Here, using publicly available DNA microarray datasets, "serial analysis of gene expression" libraries and qRT-PCR analysis, we determined that TTP mRNA is present in normal breast cells and its levels are significantly decreased in all breast cancer subtypes. In addition, by immunostaining, we found that TTP expression is higher in normal breast tissue and benign lesions than in infiltrating carcinomas. Among these, lower grade tumors showed increased TTP expression compared to higher grade cancers. Therefore, these data indicate that TTP protein levels would provide a better negative correlation with breast cancer invasiveness than TTP transcript levels. In mice, we found that TTP mRNA and protein expression is also diminished in mammary tumors. Interestingly, a strong positive association of TTP expression and mammary differentiation was identified in normal and tumor cells. In fact, TTP expression is highly increased during lactation, showing good correlation with various mammary differentiation factors. TTP expression was also induced in mammary HC11 cells treated with lactogenic hormones, mainly by prolactin, through Stat5A activation. The effect of this hormone was highly dependent on mammary differentiation status, as prolactin was unable to elicit a similar response in proliferating or neoplastic mammary cells. In summary, these studies show that TTP expression is strongly linked to the mammary differentiation program in human and mice, suggesting that this protein might play specific and relevant roles in the normal physiology of the gland. © Springer Science+Business Media, LLC. 2012. |l eng | |
| 536 | |a Detalles de la financiación: Natural Sciences and Engineering Research Council of Canada | ||
| 536 | |a Detalles de la financiación: National Research Council of Science and Technology | ||
| 536 | |a Detalles de la financiación: Fundación Alberto J. Roemmers | ||
| 536 | |a Detalles de la financiación: Agencia Nacional de Promoción Científica y Tecnológica | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas | ||
| 536 | |a Detalles de la financiación: Acknowledgments This work was supported by the grants and fellowships awarded by the National Council of Science and Technology (CONICET), the National Agency of Scientific and Technological Promotion (ANPCyT) and Fundación Roemmers, Argentina and NSERC (Canada). We thank Dr. Nancy Hynes (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland) for | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina | ||
| 593 | |a CINIBA, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, La Plata, Argentina | ||
| 593 | |a OntarioVeterinarian College, University of Guelph, ON, Canada | ||
| 593 | |a Laboratorio de Biología Del Cáncer, INIBIBB-CONICET, Centro Científico Tecnológico, Bahía Blanca, Argentina | ||
| 593 | |a Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, CM1, Pabellón 2, 2do piso, 1428 Ciudad Autónoma de Buenos Aires, Argentina | ||
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MAMMARY GLAND |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a TRISTETRAPROLIN |
| 690 | 1 | 0 | |a MESSENGER RNA |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a RNA BINDING PROTEIN |
| 690 | 1 | 0 | |a STAT5A PROTEIN |
| 690 | 1 | 0 | |a TRISTETRAPROLIN |
| 690 | 1 | 0 | |a 3' UNTRANSLATED REGION |
| 690 | 1 | 0 | |a ANIMAL TISSUE |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a AU RICH ELEMENT |
| 690 | 1 | 0 | |a BREAST CANCER |
| 690 | 1 | 0 | |a BREAST CARCINOMA |
| 690 | 1 | 0 | |a BREAST CELL |
| 690 | 1 | 0 | |a BREAST LESION |
| 690 | 1 | 0 | |a BREAST TUMOR |
| 690 | 1 | 0 | |a CANCER CELL |
| 690 | 1 | 0 | |a CANCER GRADING |
| 690 | 1 | 0 | |a CANCER INVASION |
| 690 | 1 | 0 | |a CELL PROLIFERATION |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a DNA MICROARRAY |
| 690 | 1 | 0 | |a GENE EXPRESSION |
| 690 | 1 | 0 | |a HUMAN |
| 690 | 1 | 0 | |a HUMAN TISSUE |
| 690 | 1 | 0 | |a IMMUNOHISTOCHEMISTRY |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MAMMARY GLAND |
| 690 | 1 | 0 | |a MOUSE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a PROTEIN EXPRESSION |
| 690 | 1 | 0 | |a REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION |
| 690 | 1 | 0 | |a SERIAL ANALYSIS OF GENE EXPRESSION |
| 690 | 1 | 0 | |a TISSUE DIFFERENTIATION |
| 690 | 1 | 0 | |a ANIMALS |
| 690 | 1 | 0 | |a BASE SEQUENCE |
| 690 | 1 | 0 | |a BREAST NEOPLASMS |
| 690 | 1 | 0 | |a CELL DIFFERENTIATION |
| 690 | 1 | 0 | |a CELL LINE, TUMOR |
| 690 | 1 | 0 | |a FEMALE |
| 690 | 1 | 0 | |a GENE EXPRESSION REGULATION, NEOPLASTIC |
| 690 | 1 | 0 | |a HUMANS |
| 690 | 1 | 0 | |a LACTATION |
| 690 | 1 | 0 | |a MAMMARY GLANDS, ANIMAL |
| 690 | 1 | 0 | |a MAMMARY GLANDS, HUMAN |
| 690 | 1 | 0 | |a MAMMARY NEOPLASMS, ANIMAL |
| 690 | 1 | 0 | |a MICE |
| 690 | 1 | 0 | |a MICE, INBRED BALB C |
| 690 | 1 | 0 | |a MOLECULAR SEQUENCE DATA |
| 690 | 1 | 0 | |a PREGNANCY |
| 690 | 1 | 0 | |a PROLACTIN |
| 690 | 1 | 0 | |a STAT5 TRANSCRIPTION FACTOR |
| 690 | 1 | 0 | |a TRISTETRAPROLIN |
| 690 | 1 | 0 | |a TUMOR SUPPRESSOR PROTEINS |
| 700 | 1 | |a Gattelli, A. | |
| 700 | 1 | |a Slomiansky, V. | |
| 700 | 1 | |a Lacunza, E. | |
| 700 | 1 | |a Gingerich, T. | |
| 700 | 1 | |a Tocci, J.M. | |
| 700 | 1 | |a Facchinetti, M.M. | |
| 700 | 1 | |a Curino, A.C. | |
| 700 | 1 | |a LaMarre, J. | |
| 700 | 1 | |a Abba, M.C. | |
| 700 | 1 | |a Kordon, E.C. | |
| 773 | 0 | |d 2012 |g v. 135 |h pp. 749-758 |k n. 3 |p Breast Cancer Res. Treat. |x 01676806 |t Breast Cancer Research and Treatment | |
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