ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells
The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS,...
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2012
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| LEADER | 16388caa a22018377a 4500 | ||
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| 001 | PAPER-9866 | ||
| 003 | AR-BaUEN | ||
| 005 | 20250805113047.0 | ||
| 008 | 190411s2012 xx ||||fo|||| 00| 0 eng|d | ||
| 024 | 7 | |2 scopus |a 2-s2.0-84856782425 | |
| 024 | 7 | |2 cas |a hydrogen peroxide, 7722-84-1; silicon, 7440-21-3; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9 | |
| 040 | |a Scopus |b spa |c AR-BaUEN |d AR-BaUEN | ||
| 100 | 1 | |a Gara, P.M.D. | |
| 245 | 1 | 0 | |a ROS enhancement by silicon nanoparticles in X-ray irradiated aqueous suspensions and in glioma C6 cells |
| 260 | |c 2012 | ||
| 270 | 1 | 0 | |m Gonzalez, M.C.; INIFTA, Departamento de Química, Facultad de Ciencias Exactas, CC16 Suc. 4 (1900), La Plata, Argentina; email: gonzalez@inifta.unlp.edu.ar |
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| 506 | |2 openaire |e Política editorial | ||
| 520 | 3 | |a The capability of silicon nanoparticles to increase the yield of reactive species upon 4 MeV X-ray irradiation of aqueous suspensions and C6 glioma cell cultures was investigated. ROS generation was detected and quantified using several specific probes. The particles were characterized by FTIR, XPS, TEM, DLS, luminescence, and adsorption spectroscopy before and after irradiation to evaluate the effect of high energy radiation on their structure. The total concentration of O 2 ·-/HO 2 ·, HO ·, and H 2O 2 generated upon 4-MeV X-ray irradiation of 6.4 μM silicon nanoparticle aqueous suspensions were on the order of 10 μM per Gy, ten times higher than that obtained in similar experiments but in the absence of particles. Cytotoxic 1O 2 was generated only in irradiation experiments containing the particles. The particle surface became oxidized to SiO 2 and the luminescence yield reduced with the irradiation dose. Changes in the surface morphology did not affect, within the experimental error, the yields ofROSgenerated per Gy. X-ray irradiation of glioma C6 cell cultures with incorporated silicon nanoparticles showed a marked production of ROS proportional to the radiation dose received. In the absence of nanoparticles, the cells showed no irradiation- enhanced ROS generation. The obtained results indicate that silicon nanoparticles of <5 nm size have the potential to be used as radiosensitizers for improving the outcomes of cancer radiotherapy. Their capability of producing 1O 2 upon X-ray irradiation opens novel approaches in the design of therapy strategies. © Springer Science+Business Media B.V. 2012. |l eng | |
| 536 | |a Detalles de la financiación: Spectrum Pharmaceuticals | ||
| 536 | |a Detalles de la financiación: Universidad Nacional de La Plata, UNLP | ||
| 536 | |a Detalles de la financiación: Comisión Nacional de Energía Atómica, Gobierno de Argentina, CNEA | ||
| 536 | |a Detalles de la financiación: Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET | ||
| 536 | |a Detalles de la financiación: Acknowledgments This research was supported by the grant PIP 112-200801-00356 from CONICET, Argentina. The authors thank Lic. M. Martinez from the Physical Department at CIO La Plata for his help with the irradiation of the samples, Dr. Aldo Rubbert from INIFTA for the XPS spectrum, B. Soria from CEQUINOR, UNLP for the FTIR spectra, and A. Wolosiuk from CNEA, Bs.As. for the DLS measurements. P.M.D.G. thanks Fundación Avanzar for a postgraduate fellowship. N.I.G. and M.J.L.P. thank CONICET for a studentship. M.C.G. and M.L.K. are research members of CONICET. | ||
| 593 | |a CITOMA, Fundación Avanzar, Instituto de Terapia Radiante S.A., Calle 60 Nro. 480 (1900), La Plata, Argentina | ||
| 593 | |a INIFTA, Departamento de Química, Facultad de Ciencias Exactas, CC16 Suc. 4 (1900), La Plata, Argentina | ||
| 593 | |a Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Intendente Güiraldes 2160, C1428EGA Buenos Aires, Argentina | ||
| 593 | |a Centro Atómico Bariloche, 8400 San Carlos de Bariloche, Argentina | ||
| 690 | 1 | 0 | |a GLIOMA C6 CELLS |
| 690 | 1 | 0 | |a RADIOTHERAPY |
| 690 | 1 | 0 | |a ROS |
| 690 | 1 | 0 | |a SILICON NANOPARTICLES |
| 690 | 1 | 0 | |a SINGLET MOLECULAR OXYGEN |
| 690 | 1 | 0 | |a X-RAYS |
| 690 | 1 | 0 | |a AQUEOUS SUSPENSIONS |
| 690 | 1 | 0 | |a C6 CELLS |
| 690 | 1 | 0 | |a CYTOTOXIC |
| 690 | 1 | 0 | |a EXPERIMENTAL ERRORS |
| 690 | 1 | 0 | |a FTIR |
| 690 | 1 | 0 | |a HIGH ENERGY RADIATION |
| 690 | 1 | 0 | |a IRRADIATION DOSE |
| 690 | 1 | 0 | |a IRRADIATION EXPERIMENTS |
| 690 | 1 | 0 | |a PARTICLE SURFACE |
| 690 | 1 | 0 | |a RADIOSENSITIZERS |
| 690 | 1 | 0 | |a REACTIVE SPECIES |
| 690 | 1 | 0 | |a ROS |
| 690 | 1 | 0 | |a SILICON NANOPARTICLES |
| 690 | 1 | 0 | |a SINGLET MOLECULAR OXYGEN |
| 690 | 1 | 0 | |a THERAPY STRATEGIES |
| 690 | 1 | 0 | |a X RAY IRRADIATION |
| 690 | 1 | 0 | |a ADSORPTION |
| 690 | 1 | 0 | |a CELL CULTURE |
| 690 | 1 | 0 | |a EXPERIMENTS |
| 690 | 1 | 0 | |a FOURIER TRANSFORM INFRARED SPECTROSCOPY |
| 690 | 1 | 0 | |a IRRADIATION |
| 690 | 1 | 0 | |a LUMINESCENCE |
| 690 | 1 | 0 | |a NANOPARTICLES |
| 690 | 1 | 0 | |a RADIATION |
| 690 | 1 | 0 | |a RADIOTHERAPY |
| 690 | 1 | 0 | |a SILICON OXIDES |
| 690 | 1 | 0 | |a TUMORS |
| 690 | 1 | 0 | |a X RAYS |
| 690 | 1 | 0 | |a SUSPENSIONS (FLUIDS) |
| 690 | 1 | 0 | |a HYDROGEN PEROXIDE |
| 690 | 1 | 0 | |a NANOPARTICLE |
| 690 | 1 | 0 | |a RADIOSENSITIZING AGENT |
| 690 | 1 | 0 | |a REACTIVE OXYGEN METABOLITE |
| 690 | 1 | 0 | |a SCAVENGER |
| 690 | 1 | 0 | |a SILICON |
| 690 | 1 | 0 | |a SILICON DIOXIDE |
| 690 | 1 | 0 | |a SILICON NANOPARTICLE |
| 690 | 1 | 0 | |a SINGLET OXYGEN |
| 690 | 1 | 0 | |a UNCLASSIFIED DRUG |
| 690 | 1 | 0 | |a ADSORPTION SPECTROSCOPY |
| 690 | 1 | 0 | |a ANIMAL CELL |
| 690 | 1 | 0 | |a ARTICLE |
| 690 | 1 | 0 | |a CANCER RADIOTHERAPY |
| 690 | 1 | 0 | |a CELL SUSPENSION |
| 690 | 1 | 0 | |a CHEMICAL STRUCTURE |
| 690 | 1 | 0 | |a CONTROLLED STUDY |
| 690 | 1 | 0 | |a CYTOTOXICITY |
| 690 | 1 | 0 | |a GLIOMA CELL |
| 690 | 1 | 0 | |a INFRARED SPECTROSCOPY |
| 690 | 1 | 0 | |a IONIZING RADIATION |
| 690 | 1 | 0 | |a LIGHT SCATTERING |
| 690 | 1 | 0 | |a LUMINESCENCE |
| 690 | 1 | 0 | |a NONHUMAN |
| 690 | 1 | 0 | |a PARTICLE SIZE |
| 690 | 1 | 0 | |a PRIORITY JOURNAL |
| 690 | 1 | 0 | |a RADIATION DOSE |
| 690 | 1 | 0 | |a RADIATION RESPONSE |
| 690 | 1 | 0 | |a RAT |
| 690 | 1 | 0 | |a SPECTROSCOPY |
| 690 | 1 | 0 | |a SURFACE PROPERTY |
| 690 | 1 | 0 | |a TRANSMISSION ELECTRON MICROSCOPY |
| 690 | 1 | 0 | |a TUMOR CELL CULTURE |
| 690 | 1 | 0 | |a X RAY |
| 690 | 1 | 0 | |a X RAY PHOTOELECTRON SPECTROSCOPY |
| 700 | 1 | |a Garabano, N.I. | |
| 700 | 1 | |a Portoles, M.J.L. | |
| 700 | 1 | |a Moreno, Mario Sergio Jesús | |
| 700 | 1 | |a Dodat, D. | |
| 700 | 1 | |a Casas, O.R. | |
| 700 | 1 | |a Gonzalez, M.C. | |
| 700 | 1 | |a Kotler, M.L. | |
| 773 | 0 | |d 2012 |g v. 14 |k n. 3 |p J. Nanopart. Res. |x 13880764 |t Journal of Nanoparticle Research | |
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