Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy

Objective: Tooth eruption is a multifactorial process in which bone tissue plays a prevailing<br />role. In this study we evaluated the bone overlying the developing tooth germ and the degree<br />of tooth eruption of the first mandibular molar in pups born to mothers subjected to<br...

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Autor principal: Fontanetti PA; DeLucca R; Mandalunis PM; Vermouth NT
Formato: article
Lenguaje:Inglés
Publicado: 2019
Materias:
CONSTANT LIGHT; PRENATAL STRESS; BONE HISTOMORPHOMETRY; TOOTH ERUPTION; BONE VOLUME; OSTEOCLASTS
Acceso en línea:http://hdl.handle.net/11086/13440
Aporte de:
Repositorio Digital Universitario (UNC) de Universidad Nacional de Córdoba
id I10-R141-11086-13440
record_format dspace
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-141
collection Repositorio Digital Universitario (UNC)
language Inglés
topic CONSTANT LIGHT; PRENATAL STRESS; BONE HISTOMORPHOMETRY; TOOTH ERUPTION; BONE VOLUME; OSTEOCLASTS
spellingShingle CONSTANT LIGHT; PRENATAL STRESS; BONE HISTOMORPHOMETRY; TOOTH ERUPTION; BONE VOLUME; OSTEOCLASTS
Fontanetti PA; DeLucca R; Mandalunis PM; Vermouth NT
Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
topic_facet CONSTANT LIGHT; PRENATAL STRESS; BONE HISTOMORPHOMETRY; TOOTH ERUPTION; BONE VOLUME; OSTEOCLASTS
description Objective: Tooth eruption is a multifactorial process in which bone tissue plays a prevailing<br />role. In this study we evaluated the bone overlying the developing tooth germ and the degree<br />of tooth eruption of the first mandibular molar in pups born to mothers subjected to<br />constant light during pregnancy.<br />Design: Pregnant rats were divided into two groups: mothers chronically exposed to a 12:12<br />light/light cycle (LL) from day 10 to 20 of pregnancy and controls (C) maintained on a 12:12 h<br />light/dark cycle. Pups from each group were euthanized at the age 3 or 15 days.<br />Buccolingually oriented sections of mandibles were stained with haematoxylin?eosin or<br />for histochemical detection of tartrate resistant acid phosphatase (TRAP). The histomorphometric<br />parameters evaluated were bone volume, number of osteoclasts, TRAP+ bone<br />surface, number of TRAP+ and TRAP osteoclasts per mm2 and degree of tooth eruption<br />(mm).<br />Results: It was found an increase in bone volume (LL: 58.14 4.24 vs. C: 32.31 2.16; p &lt; 0.01)<br />and a decrease in the number of osteoclasts (LL: 3.5 0.65 vs. C: 8.03 1.31; p &lt; 0.01) and<br />TRAP+ cells (LL: 0.84 0.53 vs. C: 8.59 1.26; p &lt; 0.01) in 3-day-old pups born to LL-exposed<br />mothers. These observations are consistent with the decrease in the degree of tooth eruption<br />observed in 15-day-old experimental pups (LL: 0.605 0.05 vs. C: 0.342 0.02; p &lt; 0.0001).<br />Conclusion: Our results suggest that chronic constant light applied as a pre-natal stressor<br />impairs the resorptive capacity of osteoclasts involved in the formation of the eruption<br />pathway and consequently the degree of tooth eruption.
format article
author Fontanetti PA; DeLucca R; Mandalunis PM; Vermouth NT
author_facet Fontanetti PA; DeLucca R; Mandalunis PM; Vermouth NT
author_sort Fontanetti PA; DeLucca R; Mandalunis PM; Vermouth NT
title Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
title_short Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
title_full Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
title_fullStr Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
title_full_unstemmed Impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
title_sort impairment of rat tooth eruption in pups born to mothers exposed to chronic stress during pregnancy
publishDate 2019
url http://hdl.handle.net/11086/13440
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bdutipo_str Repositorios
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