Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma
Cutaneous melanoma (CM) can originate from two main pathways: chronic sun exposure and "nevus pathway". Histologically, the first one shows marked solar elastosis (SE) (mainly in the malignant lentigo (ML) variant), unlike the second one (mild or null), which affects younger patients, with...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2019
|
| Materias: | |
| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/25671 |
| Aporte de: |
| id |
I10-R327-article-25671 |
|---|---|
| record_format |
ojs |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Español |
| format |
Artículo revista |
| topic |
melanoma; elastosis; histopathology melanoma elastosis histopathology melanoma elastosis histopatología |
| spellingShingle |
melanoma; elastosis; histopathology melanoma elastosis histopathology melanoma elastosis histopatología Mazzotta, MM Rodriguez, N Osiecki, N Maldonado, M Kaplan, R Cabalier, MED Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| topic_facet |
melanoma; elastosis; histopathology melanoma elastosis histopathology melanoma elastosis histopatología |
| author |
Mazzotta, MM Rodriguez, N Osiecki, N Maldonado, M Kaplan, R Cabalier, MED |
| author_facet |
Mazzotta, MM Rodriguez, N Osiecki, N Maldonado, M Kaplan, R Cabalier, MED |
| author_sort |
Mazzotta, MM |
| title |
Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| title_short |
Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| title_full |
Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| title_fullStr |
Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| title_full_unstemmed |
Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| title_sort |
frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma |
| description |
Cutaneous melanoma (CM) can originate from two main pathways: chronic sun exposure and "nevus pathway". Histologically, the first one shows marked solar elastosis (SE) (mainly in the malignant lentigo (ML) variant), unlike the second one (mild or null), which affects younger patients, with a history of intermittent sun exposure. In-depth analysis of these biological subcategories is important to better understand risk factors, evaluate preventive strategies and contribute to the development of new therapies.
The objective of this investigation was to evaluate the frequency of SE in non-ML CM and describe presentation of clinical-pathological variables and cell proliferation index (CPI).
Descriptive, observational and retrospective study. HNC biopsies archive. Colored sections with H/E and immunostaining with Ki-67. Exclusion criteria: LM variant. Variables: sex, age, histological variant, Breslow, Clark, ulceration, mitosis, vascular invasion, cell morphology, solar elastosis (null, mild, moderate, severe) and CPI (%). Descriptive statistics.
Of 36 patients, 50% were men and 50% women. Average age: 60.2 years (26-86). Variants: 26 cases (72%) nodular, 5 superficial spreading (14%), 3 acrolentiginous (8%), 1 nevoid (3%) and 1 balloon cell (3%). Average Breslow: 4.9 mm (1.5-15 mm). 26 (72.2%) Clark IV and 10 (27.8%) Clark V. 22 (61.1%) ulcerated. 3 (8.3%) with vascular invasion. 29 (80.6%) with epitheloid cells, 6 (16.7%) with fusiform cells and 1 (2.7%) mixed. Solar elastosis: null in 13 cases (36.1%), mild in 15 (41.7%), moderate in 7 (19.4%) and severe in 1 (2.7%). Average CPI: 15% (1-50%). No histological remnant of nevi was found in any case.
The majority of cases were nodular melanomas with mild or no SE. The presence of SE in moderate and severe intensity in several cases (19.4% and 2.7%) could indicate that chronic sun exposure also plays a role in oncogenesis in addition to the “nevus pathway” in non-ML CM, which would highlight the importance of adequate sun protection not only in summer but also daily especially in low phototypes, as a preventive action, in addition to periodic control of melanocytic nevi. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2019 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/25671 |
| work_keys_str_mv |
AT mazzottamm frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT rodriguezn frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT osieckin frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT maldonadom frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT kaplanr frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT cabaliermed frequencyofchronichistologicalphotodageclinicalpathologicalvariablesandcellproliferationindexinnonmalignantlentigocutaneousmelanoma AT mazzottamm frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno AT rodriguezn frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno AT osieckin frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno AT maldonadom frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno AT kaplanr frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno AT cabaliermed frecuenciadefotodanohistologicocronicovariablesclinicopatologicaseindicedeproliferacioncelularenmelanomacutaneonolentigomaligno |
| first_indexed |
2024-09-03T21:00:53Z |
| last_indexed |
2024-09-03T21:00:53Z |
| _version_ |
1809210150450364416 |
| spelling |
I10-R327-article-256712024-08-27T18:26:04Z Frequency of chronic histological photodage, clinical-pathological variables and cell proliferation index in non-malignant lentigo cutaneous melanoma Frecuencia de fotodaño histológico crónico, variables clínico-patológicas e índice de proliferación celular en melanoma cutáneo no lentigo maligno Mazzotta, MM Rodriguez, N Osiecki, N Maldonado, M Kaplan, R Cabalier, MED melanoma; elastosis; histopathology melanoma elastosis histopathology melanoma elastosis histopatología Cutaneous melanoma (CM) can originate from two main pathways: chronic sun exposure and "nevus pathway". Histologically, the first one shows marked solar elastosis (SE) (mainly in the malignant lentigo (ML) variant), unlike the second one (mild or null), which affects younger patients, with a history of intermittent sun exposure. In-depth analysis of these biological subcategories is important to better understand risk factors, evaluate preventive strategies and contribute to the development of new therapies. The objective of this investigation was to evaluate the frequency of SE in non-ML CM and describe presentation of clinical-pathological variables and cell proliferation index (CPI). Descriptive, observational and retrospective study. HNC biopsies archive. Colored sections with H/E and immunostaining with Ki-67. Exclusion criteria: LM variant. Variables: sex, age, histological variant, Breslow, Clark, ulceration, mitosis, vascular invasion, cell morphology, solar elastosis (null, mild, moderate, severe) and CPI (%). Descriptive statistics. Of 36 patients, 50% were men and 50% women. Average age: 60.2 years (26-86). Variants: 26 cases (72%) nodular, 5 superficial spreading (14%), 3 acrolentiginous (8%), 1 nevoid (3%) and 1 balloon cell (3%). Average Breslow: 4.9 mm (1.5-15 mm). 26 (72.2%) Clark IV and 10 (27.8%) Clark V. 22 (61.1%) ulcerated. 3 (8.3%) with vascular invasion. 29 (80.6%) with epitheloid cells, 6 (16.7%) with fusiform cells and 1 (2.7%) mixed. Solar elastosis: null in 13 cases (36.1%), mild in 15 (41.7%), moderate in 7 (19.4%) and severe in 1 (2.7%). Average CPI: 15% (1-50%). No histological remnant of nevi was found in any case. The majority of cases were nodular melanomas with mild or no SE. The presence of SE in moderate and severe intensity in several cases (19.4% and 2.7%) could indicate that chronic sun exposure also plays a role in oncogenesis in addition to the “nevus pathway” in non-ML CM, which would highlight the importance of adequate sun protection not only in summer but also daily especially in low phototypes, as a preventive action, in addition to periodic control of melanocytic nevi. El melanoma cutáneo (MC) puede originarse de dos vías principales: exposición solar crónica y “vía del nevo”. Histológicamente en la primera se observa marcada elastosis solar (ES), (principalmente en variante lentigo maligno (LM)), a diferencia de la segunda (leve o nula), que afecta pacientes más jóvenes, con historia de exposición solar intermitente. El análisis en profundidad de estas subcategorías biológicas es importante para entender mejor los factores de riesgo, evaluar estrategias preventivas y contribuir al desarrollo de nuevas terapias. El objetivo del estudio fue evaluar frecuencia de ES en MC no LM y describir presentación de variables clínico-patológicas e índice de proliferación celular (IPC). Estudio descriptivo, observacional y retrospectivo. Biopsias de archivo del HNC. Cortes coloreados con H/E e inmunomarcación con Ki-67. Criterio de exclusión: variante LM. Variables: sexo, edad, variante histológica, Breslow, Clark, ulceración, mitosis, invasión vascular, morfología celular, elastosis solar (nula, leve, moderada, severa) e IPC (%). Estadística descriptiva. De 36 pacientes, 50% fueron hombres y 50% mujeres. Edad promedio: 60,2 años(26-86). Variantes: 26 casos(72%) nodulares, 5 extensivos superficiales (14%), 3 acrolentiginosos (8%), 1 nevoide (3%) y 1 globoide (3%). Breslow promedio: 4,9 mm (1,5-15 mm). 26(72,2%) Clark IV y 10(27,8%) Clark V. 22(61,1%) ulcerados. 3(8,3%) con invasión vascular. 29(80,6%) con células epiteloides, 6(16,7%) con células fusadas y 1 (2,7%) mixto. Elastosis solar: nula 13 casos (36,1%), leve 15 (41,7%), moderada 7 (19,4%) y severa 1 (2,7%). IPC promedio: 15% (1-50%). No se encontró remanente histológico névico en ningún caso. La mayoría de los casos fueron melanomas nodulares y la ES leve o nula. La presencia de ES en intensidad moderada y severa en varios casos (19,4% y 2,7%) podría indicar que la exposición solar crónica también juega un papel en la oncogénesis además de la “vía del nevo” en MC no LM, lo cual remarcaría la importancia de la protección solar adecuada no sólo estival sino también diaria sobre todo en fototipos bajos, como acción preventiva, además del control periódico de nevos melanocíticos. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2019-10-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/25671 Revista de la Facultad de Ciencias Médicas de Córdoba.; 2019: Suplemento JIC XX Revista de la Facultad de Ciencias Médicas de Córdoba; 2019: Suplemento JIC XX Revista da Faculdade de Ciências Médicas de Córdoba; 2019: Suplemento JIC XX 1853-0605 0014-6722 10.31053/1853.0605.v76.nSuplemento spa https://revistas.unc.edu.ar/index.php/med/article/view/25671/27383 Derechos de autor 2019 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |