Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review
Abstract: Head and Neck Cancer (HNC) is associated with an immunosuppressive tumor activity of the microenvironment that has been associated with tumor progression. Several simple genetic polymorphisms (SNPs) have been studied to understand and modulate immunotherapy treatments. Due t...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35068 |
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I10-R327-article-35068 |
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Universidad Nacional de Córdoba |
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Revista de la Facultad de Ciencias Médicas de Córdoba |
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Artículo revista |
| topic |
cytokines cancer of head and neck polymorphisms risk factor systematic review cytokines cancer of head and neck polymorphisms risk factor systematic review . |
| spellingShingle |
cytokines cancer of head and neck polymorphisms risk factor systematic review cytokines cancer of head and neck polymorphisms risk factor systematic review . Unamuno, V Brunotto , M Zarate , AM Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| topic_facet |
cytokines cancer of head and neck polymorphisms risk factor systematic review cytokines cancer of head and neck polymorphisms risk factor systematic review . |
| author |
Unamuno, V Brunotto , M Zarate , AM |
| author_facet |
Unamuno, V Brunotto , M Zarate , AM |
| author_sort |
Unamuno, V |
| title |
Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| title_short |
Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| title_full |
Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| title_fullStr |
Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| title_full_unstemmed |
Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| title_sort |
polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review |
| description |
Abstract:
Head and Neck Cancer (HNC) is associated with an immunosuppressive tumor activity of the microenvironment that has been associated with tumor progression. Several simple genetic polymorphisms (SNPs) have been studied to understand and modulate immunotherapy treatments. Due to the high number and variety of cytokine SNPs present in the tumor microenvironment, a systematic review and meta-analysis on SNPs related to inflammation and risk of HNC was made. The study was carried out under the PRISMA guidelines. The bibliographic research included case-control articles until December 2020, in PubMed, Scielo and Sciencedirect using the following keywords: polymorphism, gene, cytokines, interleukins, tumor growth factor, necrosis factor tumor, head-neck-cancer. Inclusion criteria: patients with pathological diagnosis; polymorphisms detected by PCR; original full-text articles. A double-blind evaluation was carried out, obtaining the following data from each article: author, year of publication, country, sample size, type of cancer, detection test and frequency of alleles / genotypes. According to the MOOSE guidelines, a score was established, excluding low-quality studies. ORs (95% CI) were used to assess the association between genotype and cancer risk. The 1874 articles consulted included 44 form Asia, 11 from Europe, 2 from South America and 1 from Africa, referring to a total of 7019 cases and 10138 controls with an average age between 50-60 years. The following polymorphisms showed a significant association with an increased risk of HNC: IL10 592 AC / CC, IL6 174GC, TNFα308 GA / GG, TNFβ 252 B1B1 / B1B2, IL10 1082 AG / GG, TNFα 857CC, TNFα 1031TT, LTA 252, MCP -1 A2518 GG + GA, TGFβ 10TC, TGFβ 25GC, SDF-1 801AG, IL4 590, IL18 137, CCL5 28 GC, CCL5 403CT / TT. The MMP13 polymorphism is associated with decreased risk. The presence of mutated variants of IL-4, IL-6, IL-8 and SDF-1 generate an inflammatory environment favorable to the risk of HNC.
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| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2021 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35068 |
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I10-R327-article-350682024-04-15T16:19:09Z Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review Polimorfismos de mediadores inflamatorios como factor de riesgo de cáncer de cabeza y cuello: Una Revisión sistemática A Unamuno, V Brunotto , M Zarate , AM cytokines cancer of head and neck polymorphisms risk factor systematic review cytokines cancer of head and neck polymorphisms risk factor systematic review . Abstract: Head and Neck Cancer (HNC) is associated with an immunosuppressive tumor activity of the microenvironment that has been associated with tumor progression. Several simple genetic polymorphisms (SNPs) have been studied to understand and modulate immunotherapy treatments. Due to the high number and variety of cytokine SNPs present in the tumor microenvironment, a systematic review and meta-analysis on SNPs related to inflammation and risk of HNC was made. The study was carried out under the PRISMA guidelines. The bibliographic research included case-control articles until December 2020, in PubMed, Scielo and Sciencedirect using the following keywords: polymorphism, gene, cytokines, interleukins, tumor growth factor, necrosis factor tumor, head-neck-cancer. Inclusion criteria: patients with pathological diagnosis; polymorphisms detected by PCR; original full-text articles. A double-blind evaluation was carried out, obtaining the following data from each article: author, year of publication, country, sample size, type of cancer, detection test and frequency of alleles / genotypes. According to the MOOSE guidelines, a score was established, excluding low-quality studies. ORs (95% CI) were used to assess the association between genotype and cancer risk. The 1874 articles consulted included 44 form Asia, 11 from Europe, 2 from South America and 1 from Africa, referring to a total of 7019 cases and 10138 controls with an average age between 50-60 years. The following polymorphisms showed a significant association with an increased risk of HNC: IL10 592 AC / CC, IL6 174GC, TNFα308 GA / GG, TNFβ 252 B1B1 / B1B2, IL10 1082 AG / GG, TNFα 857CC, TNFα 1031TT, LTA 252, MCP -1 A2518 GG + GA, TGFβ 10TC, TGFβ 25GC, SDF-1 801AG, IL4 590, IL18 137, CCL5 28 GC, CCL5 403CT / TT. The MMP13 polymorphism is associated with decreased risk. The presence of mutated variants of IL-4, IL-6, IL-8 and SDF-1 generate an inflammatory environment favorable to the risk of HNC. Resumen: El Cáncer de Cabeza y Cuello (CCC) está asociado con una actividad tumoral inmunosupresora del microambiente que se ha asociado con la progresión tumoral. Varios polimorfismos genéticos simples (SNP) se han estudiado para comprender y modular los tratamientos de inmunoterapia. Dada el elevado número y variedad de SNPs de citoquinas presentes en el microambiente tumoral nos propusimos realizar una revisión sistemática y metaanálisis sobre SNPs relacionados a inflamación y riesgo de CCC. Se realizó un estudio bajo los delineamientos PRISMA, la búsqueda bibliográfica comprendió hasta diciembre 2020, de artículos caso-control, en PubMed, Scielo y Sciencedirect utilizando las palabras claves: polimorfismo, gen, citoquinas, interleucinas, factor de crecimiento tumoral, factor de necrosis tumoral, head-neck-cancer. Criterios de inclusión: pacientes con diagnóstico anatomopatológico; polimorfismos detectados por PCR; artículos originales de texto completo. Se realizó una evaluación doble ciego obteniéndose los siguientes datos de cada artículo: autor, año de publicación, país, tamaño de la muestra, tipo de cáncer, prueba de detección y frecuencia de alelos / genotipos. Según las directrices MOOSE se estableció una puntuación, excluyéndose los estudios de baja calidad. Se utilizaron los OR (IC del 95%) para evaluar asociación entre genotipo y riesgo de cáncer. De 1874 artículos se incluyeron 44 de Asia 30, Europa 11, América del Sur 2 y África 1 con un total de 7019 casos y 10138 controles con promedio de edad de 50-60 años. Los siguientes polimorfismos presentaron una asociación significativa con un mayor riesgo de HNC: IL10 592 AC/CC, IL6 174GC, TNFα308 GA/GG, TNFβ 252 B1B1/B1B2, IL10 1082 AG/GG, TNFα 857CC, TNFα 1031TT, LTA 252, MCP-1 A2518 GG+GA, TGFβ 10TC, TGFβ 25GC, SDF-1 801AG, IL4 590, IL18 137, CCL5 28 GC, CCL5 403CT/TT. El polimorfismo MMP13 se asocia con disminución del riesgo. La presencia de variantes mutadas de IL-4, IL-6, IL-8 y SDF-1 generan un ambiente inflamatorio favorable para el riesgo de HNC . Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2021-10-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto texto texto https://revistas.unc.edu.ar/index.php/med/article/view/35068 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 78 No. Suplemento (2021): Suplemento JIC XXII Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 78 Núm. Suplemento (2021): Suplemento JIC XXII Revista da Faculdade de Ciências Médicas de Córdoba; v. 78 n. Suplemento (2021): Suplemento JIC XXII 1853-0605 0014-6722 http://creativecommons.org/licenses/by-nc/4.0 |