Polymorphisms of inflammatory mediators as a risk factor for head and neck cancer: a systematic review
Abstract: Head and Neck Cancer (HNC) is associated with an immunosuppressive tumor activity of the microenvironment that has been associated with tumor progression. Several simple genetic polymorphisms (SNPs) have been studied to understand and modulate immunotherapy treatments. Due t...
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| Autores principales: | , , |
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| Formato: | Artículo revista |
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2021
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35068 |
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| Sumario: | Abstract:
Head and Neck Cancer (HNC) is associated with an immunosuppressive tumor activity of the microenvironment that has been associated with tumor progression. Several simple genetic polymorphisms (SNPs) have been studied to understand and modulate immunotherapy treatments. Due to the high number and variety of cytokine SNPs present in the tumor microenvironment, a systematic review and meta-analysis on SNPs related to inflammation and risk of HNC was made. The study was carried out under the PRISMA guidelines. The bibliographic research included case-control articles until December 2020, in PubMed, Scielo and Sciencedirect using the following keywords: polymorphism, gene, cytokines, interleukins, tumor growth factor, necrosis factor tumor, head-neck-cancer. Inclusion criteria: patients with pathological diagnosis; polymorphisms detected by PCR; original full-text articles. A double-blind evaluation was carried out, obtaining the following data from each article: author, year of publication, country, sample size, type of cancer, detection test and frequency of alleles / genotypes. According to the MOOSE guidelines, a score was established, excluding low-quality studies. ORs (95% CI) were used to assess the association between genotype and cancer risk. The 1874 articles consulted included 44 form Asia, 11 from Europe, 2 from South America and 1 from Africa, referring to a total of 7019 cases and 10138 controls with an average age between 50-60 years. The following polymorphisms showed a significant association with an increased risk of HNC: IL10 592 AC / CC, IL6 174GC, TNFα308 GA / GG, TNFβ 252 B1B1 / B1B2, IL10 1082 AG / GG, TNFα 857CC, TNFα 1031TT, LTA 252, MCP -1 A2518 GG + GA, TGFβ 10TC, TGFβ 25GC, SDF-1 801AG, IL4 590, IL18 137, CCL5 28 GC, CCL5 403CT / TT. The MMP13 polymorphism is associated with decreased risk. The presence of mutated variants of IL-4, IL-6, IL-8 and SDF-1 generate an inflammatory environment favorable to the risk of HNC.
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