Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications
Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25...
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Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
2022
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/med/article/view/35158 |
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I10-R327-article-35158 |
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Universidad Nacional de Córdoba |
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I-10 |
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R-327 |
| container_title_str |
Revista de la Facultad de Ciencias Médicas de Córdoba |
| language |
Inglés |
| format |
Artículo revista |
| topic |
diabetes mellitus vitamin D albuminuria diabetes mellitus vitamina D albuminuria diabetes mellitus vitamina D albuminúria |
| spellingShingle |
diabetes mellitus vitamin D albuminuria diabetes mellitus vitamina D albuminuria diabetes mellitus vitamina D albuminúria Ramírez Stieben, Luis Agustín Dobry, Raquel Anca, Lilian González, Adrián López, María Isabel Bayo, Salvador Sánchez, Ariel Brance, María Lorena Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| topic_facet |
diabetes mellitus vitamin D albuminuria diabetes mellitus vitamina D albuminuria diabetes mellitus vitamina D albuminúria |
| author |
Ramírez Stieben, Luis Agustín Dobry, Raquel Anca, Lilian González, Adrián López, María Isabel Bayo, Salvador Sánchez, Ariel Brance, María Lorena |
| author_facet |
Ramírez Stieben, Luis Agustín Dobry, Raquel Anca, Lilian González, Adrián López, María Isabel Bayo, Salvador Sánchez, Ariel Brance, María Lorena |
| author_sort |
Ramírez Stieben, Luis Agustín |
| title |
Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| title_short |
Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| title_full |
Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| title_fullStr |
Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| title_full_unstemmed |
Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| title_sort |
hypovitaminosis d in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications |
| description |
Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25OHD, glycemic control and chronic complications of T2DM.
Methods. A cross-sectional study was carried out, in which 25OHD levels were evaluated in adult patients (over 18 years) with T2DM. Correlation analyses were performed to evaluate the interdependence of the 25OHD with other continuous variables. A receiver operating characteristic analysis was also performed to identify cutoff values for diagnosing vitamin D deficiency. Logistic regression was performed to identify the independent association between vitamin D deficiency and the variables associated with lower 25OHD.
Results. 208 patients were analyzed. The mean age of the patients was 62 years. The 25OHD level was 19 ng/ml (IQR 13.28-24.43), 59.78% had vitamin D deficiency, and 10.33% had severe deficiency. Glycemia, HbA1c, and BMI were negatively correlated with 25OHD. Cutoff point for vitamin D deficiency was 33.39 kg/m2 for body mass index (BMI), 123 mg/dl for glycemia, and 6.65% for HbA1c. In multivariate logistic regression, BMI>33.39 kg/m2, glycemia >123.5 mg/dl, and albuminuria presented higher odds of vitamin D deficiency.
Major conclusion. Vitamin D deficiency was highly prevalent among patients with T2DM. Low levels were related to higher fasting plasma glucose, higher BMI, and diabetic nephropathy. |
| publisher |
Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología |
| publishDate |
2022 |
| url |
https://revistas.unc.edu.ar/index.php/med/article/view/35158 |
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2024-09-03T21:03:15Z |
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2024-09-03T21:03:15Z |
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I10-R327-article-351582022-09-29T15:08:29Z Hypovitaminosis D in patients with type 2 diabetes : risk factors and association with glycemic control and established microvascular complications Hipovitaminosis D en pacientes con diabetes tipo 2: factores de riesgo y asociación con control glucémico y complicaciones microvasculares establecidas Hipovitaminose D em pacientes com diabetes tipo 2 : fatores de risco e associação com controle glicêmico e complicações microvasculares estabelecidas Ramírez Stieben, Luis Agustín Dobry, Raquel Anca, Lilian González, Adrián López, María Isabel Bayo, Salvador Sánchez, Ariel Brance, María Lorena diabetes mellitus vitamin D albuminuria diabetes mellitus vitamina D albuminuria diabetes mellitus vitamina D albuminúria Introduction. Several studies reported than vitamin D deficiency increases the risk of macrovascular and microvascular disease in patients with type 2 diabetes (T2DM). We investigated the plasma levels of 25OHD in adult patients T2DM, risk factors for 25OHD deficiency and the relationship between 25OHD, glycemic control and chronic complications of T2DM. Methods. A cross-sectional study was carried out, in which 25OHD levels were evaluated in adult patients (over 18 years) with T2DM. Correlation analyses were performed to evaluate the interdependence of the 25OHD with other continuous variables. A receiver operating characteristic analysis was also performed to identify cutoff values for diagnosing vitamin D deficiency. Logistic regression was performed to identify the independent association between vitamin D deficiency and the variables associated with lower 25OHD. Results. 208 patients were analyzed. The mean age of the patients was 62 years. The 25OHD level was 19 ng/ml (IQR 13.28-24.43), 59.78% had vitamin D deficiency, and 10.33% had severe deficiency. Glycemia, HbA1c, and BMI were negatively correlated with 25OHD. Cutoff point for vitamin D deficiency was 33.39 kg/m2 for body mass index (BMI), 123 mg/dl for glycemia, and 6.65% for HbA1c. In multivariate logistic regression, BMI>33.39 kg/m2, glycemia >123.5 mg/dl, and albuminuria presented higher odds of vitamin D deficiency. Major conclusion. Vitamin D deficiency was highly prevalent among patients with T2DM. Low levels were related to higher fasting plasma glucose, higher BMI, and diabetic nephropathy. Introducción. Varios estudios reportaron que la deficiencia de vitamina D aumenta el riesgo de enfermedad macrovascular y microvascular en pacientes con diabetes tipo 2 (DM2). Investigamos los niveles de 25OHD en adultos con DM2, factores de riesgo de deficiencia de 25OHD y relación entre 25OHD, control glucémico y complicaciones crónicas de la DM2. Métodos. Se realizó un estudio transversal en el que se evaluaron los niveles de 25OHD en adultos (mayores de 18 años) con DM2. Se realizaron análisis de correlación para evaluar la interdependencia de la 25OHD con otras variables continuas. Se realizó un análisis de las características operativas del receptor para identificar valores de corte para diagnóstico de deficiencia de vitamina D. Se realizó una regresión logística para identificar asociación independiente entre deficiencia de 25OHD y variables asociadas con una menor 25OHD. Resultados. Se analizaron 208 pacientes. La edad media fue 62 años. El nivel de 25OHD fue 19 ng/ml (IQR 13.28-24.43), 59.78% tenía deficiencia de vitamina D y 10.33% tenía deficiencia severa. Glucemia, HbA1c y IMC correlacionaron negativamente con 25OHD. El punto de corte para deficiencia de vitamina D fue 33,39 kg/m2 para índice de masa corporal (IMC), 123 mg/dl para glucemia y 6,65% para HbA1c. En la regresión logística multivariada, IMC >33,39 kg/m2, glucemia >123,5 mg/dl y albuminuria presentaron mayores probabilidades de deficiencia de vitamina D. Conclusión principal. La deficiencia de vitamina D fue altamente prevalente en los pacientes con DM2. Niveles bajos de 25OHD se relacionaron con mayor glucemia, mayor IMC y nefropatía diabética. Introdução. Vários estudos relataram que a deficiência de vitamina D aumenta o risco de doença macrovascular e microvascular em pacientes com diabetes tipo 2 (DM2). Nós investigamos os níveis de 25OHD em adultos com DM2, fatores de risco para deficiência de 25OHD e a relação entre 25OHD, controle glicêmico e complicações crônicas do DM2. Métodos. Foi realizado um estudo transversal em que os níveis de 25OHD foram avaliados em adultos (maiores de 18 anos) com DM2. Análises de correlação foram realizadas para avaliar a interdependência de 25OHD com outras variáveis contínuas. Uma análise das características operatórias do receptor foi realizada para identificar valores de corte para o diagnóstico de deficiência de vitamina D. Uma regressão logística foi realizada para identificar uma associação independente entre a deficiência de 25OHD e variáveis associadas a uma menor 25OHD. Resultados. 208 pacientes foram analisados. A média de idade foi de 62 anos. O nível de 25OHD foi de 19 ng/ml (IQR 13,28-24,43), 59,78% eram deficientes em vitamina D e 10,33% eram severamente deficientes. Glicemia, HbA1c e IMC correlacionaram-se negativamente com 25OHD. O ponto de corte para deficiência de vitamina D foi de 33,39 kg/m2 para índice de massa corporal (IMC), 123 mg/dl para glicose no sangue e 6,65% para HbA1c. Na regressão logística multivariada, IMC> 33,39 kg/m2, glicemia >123,5 mg/dl e albuminúria apresentaram maiores probabilidades de deficiência de vitamina D. Conclusão principal. A deficiência de vitamina D foi altamente prevalente em pacientes com DM2. Níveis baixos de 25OHD foram associados a maior glicose no sangue, maior IMC e nefropatia diabética. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2022-09-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text texto texto application/pdf text/html https://revistas.unc.edu.ar/index.php/med/article/view/35158 10.31053/1853.0605.v79.n3.35158 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 79 No. 3 (2022); 235-240 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 79 Núm. 3 (2022); 235-240 Revista da Faculdade de Ciências Médicas de Córdoba; v. 79 n. 3 (2022); 235-240 1853-0605 0014-6722 10.31053/1853.0605.v79.n3 eng https://revistas.unc.edu.ar/index.php/med/article/view/35158/38758 https://revistas.unc.edu.ar/index.php/med/article/view/35158/37757 Derechos de autor 2022 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0 |