Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (CSCC) is the second most common primary neoplasm of the skin. It is associated with multiple risk factors, the main one being exposure to UV radiation. Numerous studies show that the greater presence of dendritic cells (DC) and, specifically, Langerhans cells (LC)...

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Autores principales: Stuppa, T, Armatti, MA, Ferro, AA, Taddei , E, Mukdsi , JH, Cabalier, MED, Cremonezzi, DC, Mazzotta, MM
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023
Materias:
skin
squamous cell carcinoma
dendritic cells
S100
piel
carcinoma de células escamosas
células dendríticas
Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/42645
Aporte de:
Revista de la Facultad de Ciencias Médicas de Córdoba de Universidad Nacional de Córdoba
id I10-R327-article-42645
record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Español
format Artículo revista
topic skin
squamous cell carcinoma
dendritic cells
S100
piel
carcinoma de células escamosas
células dendríticas
S100
spellingShingle skin
squamous cell carcinoma
dendritic cells
S100
piel
carcinoma de células escamosas
células dendríticas
S100
Stuppa, T
Armatti, MA
Ferro, AA
Taddei , E
Mukdsi , JH
Cabalier, MED
Cremonezzi, DC
Mazzotta, MM
Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
topic_facet skin
squamous cell carcinoma
dendritic cells
S100
piel
carcinoma de células escamosas
células dendríticas
S100
author Stuppa, T
Armatti, MA
Ferro, AA
Taddei , E
Mukdsi , JH
Cabalier, MED
Cremonezzi, DC
Mazzotta, MM
author_facet Stuppa, T
Armatti, MA
Ferro, AA
Taddei , E
Mukdsi , JH
Cabalier, MED
Cremonezzi, DC
Mazzotta, MM
author_sort Stuppa, T
title Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
title_short Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
title_full Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
title_fullStr Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
title_full_unstemmed Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma
title_sort determination of the relationship between the population of dendritic cells by protein s100 and the biological behavior of cutaneous squamous cell carcinoma
description Cutaneous squamous cell carcinoma (CSCC) is the second most common primary neoplasm of the skin. It is associated with multiple risk factors, the main one being exposure to UV radiation. Numerous studies show that the greater presence of dendritic cells (DC) and, specifically, Langerhans cells (LC) in neoplasms of other locations is related to beneficial prognostic factors. The potential of DCs to amplify antigen-specific immune responses has been shown to make them candidates for cancer immunotherapy. These can be studied by immunohistochemistry with staining for S100 and CD1a. The objective is to study the correlation between the density of dendritic cells and the degree of differentiation of CSCC to estimate the course and prognosis. All CSCC cases (n=14) belonged to the period 2017-2022 and the sampling was non-probability for convenience. Staining with H/E and immunohistochemical technique with S100 were performed. Multiple variables of prognostic relevance, which are related to biological behavior, and its comparison with the number of CDs, were analyzed using statistical analysis with Infostat software (frequency distribution, position and dispersion measures, and Fischer-Chi square test). It was seen that the higher the number of DCs, the tumors were more differentiated (p=0.0029) and presented less tumor necrosis (p=0.05). The study carried out supports previous analyzes reported in the literature, which show that the greater the number of dendritic cells in the tumor microenvironment, the better the differentiation of CCECs, being a favorable prognostic factor.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2023
url https://revistas.unc.edu.ar/index.php/med/article/view/42645
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first_indexed 2024-09-03T21:04:40Z
last_indexed 2024-09-03T21:04:40Z
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spelling I10-R327-article-426452023-10-19T21:20:27Z Determination of the relationship between the population of dendritic cells by protein S100 and the biological behavior of cutaneous squamous cell carcinoma Determinación de la relación entre la población de las células dendríticas mediante proteína S100 con la conducta biológica del carcinoma de células escamosas cutáneo Stuppa, T Armatti, MA Ferro, AA Taddei , E Mukdsi , JH Cabalier, MED Cremonezzi, DC Mazzotta, MM skin squamous cell carcinoma dendritic cells S100 piel carcinoma de células escamosas células dendríticas S100 Cutaneous squamous cell carcinoma (CSCC) is the second most common primary neoplasm of the skin. It is associated with multiple risk factors, the main one being exposure to UV radiation. Numerous studies show that the greater presence of dendritic cells (DC) and, specifically, Langerhans cells (LC) in neoplasms of other locations is related to beneficial prognostic factors. The potential of DCs to amplify antigen-specific immune responses has been shown to make them candidates for cancer immunotherapy. These can be studied by immunohistochemistry with staining for S100 and CD1a. The objective is to study the correlation between the density of dendritic cells and the degree of differentiation of CSCC to estimate the course and prognosis. All CSCC cases (n=14) belonged to the period 2017-2022 and the sampling was non-probability for convenience. Staining with H/E and immunohistochemical technique with S100 were performed. Multiple variables of prognostic relevance, which are related to biological behavior, and its comparison with the number of CDs, were analyzed using statistical analysis with Infostat software (frequency distribution, position and dispersion measures, and Fischer-Chi square test). It was seen that the higher the number of DCs, the tumors were more differentiated (p=0.0029) and presented less tumor necrosis (p=0.05). The study carried out supports previous analyzes reported in the literature, which show that the greater the number of dendritic cells in the tumor microenvironment, the better the differentiation of CCECs, being a favorable prognostic factor. El carcinoma de células escamosas cutáneo (CCEC) es la segunda neoplasia primaria más frecuente de la piel. Se asocia a múltiples factores de riesgo siendo el principal la exposición a la radiación UV. Numerosos estudios demuestran que la mayor presencia de células dendríticas (CD) y, en específico, las células de Langerhans (CL) en las neoplasias de otras localizaciones se relaciona con factores pronósticos beneficiosos. Se ha visto que el potencial de las CD para amplificar la respuesta inmune antígeno específica las hace candidatas para inmunoterapia contra el cáncer. Estas pueden ser estudiadas por inmunohistoquímica con tinción para S100 y CD1a. El objetivo es estudiar el nivel de correlación entre la densidad de las células dendríticas y el grado de diferenciación de los carcinomas de células escamosas cutáneo para estimar la evolución y el pronóstico. Se estudiaron todos los casos de CCEC (n 14), entre 2017 y 2022. Se realizaron coloraciones con H/E y técnica de inmunohistoquímica con S100. Se analizaron múltiples variables de relevancia epidemiológica, clínicas e histopatológicas, que se relacionan con la conducta bilógica y se compararon con el número de CD, utilizando análisis estadístico con software Infostat (distribución de frecuencias, medidas de posición y dispersión, y prueba de Fischer- Chi cuadrado). Se vio que a mayor número de CD los tumores fueron más diferenciados (p=0,0029) y presentaban menos necrosis tumoral (p=0,05). El estudio realizado apoya análisis previos reportados en la literatura, que muestran que la disminución en el número de células dendríticas en el microambiente tumoral le permite a los carcinomas de células escamosas cutáneos desarrollarse y crecer, generando una menor diferenciación de los mismos, siendo esto un factor pronóstico negativo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2023-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/42645 Revista de la Facultad de Ciencias Médicas de Córdoba.; Vol. 80 (2023): Suplemento JIC XXIV Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 80 (2023): Suplemento JIC XXIV Revista da Faculdade de Ciências Médicas de Córdoba; v. 80 (2023): Suplemento JIC XXIV 1853-0605 0014-6722 spa https://revistas.unc.edu.ar/index.php/med/article/view/42645/42850 Derechos de autor 2023 Universidad Nacional de Córdoba http://creativecommons.org/licenses/by-nc/4.0

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