SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine

Introduction: SARS-CoV-2 can lead to a more severe infection during pregnancy. However, population-level data on COVID-19 disease and vaccine uptake in this population group are lacking, especially in South America. Objective:We aimed to describe SARS-CoV-2 infection in pregnant women from a central...

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Autores principales: D´Augero, Leticia, Castro, Gonzalo M., Sicilia, Paola, Cecchetto, Eugenio, Lopez, Laura, Scruzzi, Graciela, Barbero, Paula, Diaz, Maria del Pilar, Babas, Maria Gabriela, Re, Viviana, Pisano, Maria Belen
Formato: Artículo revista
Lenguaje:Inglés
Publicado: Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025
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Acceso en línea:https://revistas.unc.edu.ar/index.php/med/article/view/45927
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record_format ojs
institution Universidad Nacional de Córdoba
institution_str I-10
repository_str R-327
container_title_str Revista de la Facultad de Ciencias Médicas de Córdoba
language Inglés
format Artículo revista
topic sars-cov-2
covid-19
pregnancy
Argentina
epidemiology
sars-cov-2
covid-19
embarazo
Argentina
epidemioligia
sars-cov-2
covid-19
gravidez
Argentina
epidemiologia
spellingShingle sars-cov-2
covid-19
pregnancy
Argentina
epidemiology
sars-cov-2
covid-19
embarazo
Argentina
epidemioligia
sars-cov-2
covid-19
gravidez
Argentina
epidemiologia
D´Augero, Leticia
Castro, Gonzalo M.
Sicilia, Paola
Cecchetto, Eugenio
Lopez, Laura
Scruzzi, Graciela
Barbero, Paula
Diaz, Maria del Pilar
Babas, Maria Gabriela
Re, Viviana
Pisano, Maria Belen
SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
topic_facet sars-cov-2
covid-19
pregnancy
Argentina
epidemiology
sars-cov-2
covid-19
embarazo
Argentina
epidemioligia
sars-cov-2
covid-19
gravidez
Argentina
epidemiologia
author D´Augero, Leticia
Castro, Gonzalo M.
Sicilia, Paola
Cecchetto, Eugenio
Lopez, Laura
Scruzzi, Graciela
Barbero, Paula
Diaz, Maria del Pilar
Babas, Maria Gabriela
Re, Viviana
Pisano, Maria Belen
author_facet D´Augero, Leticia
Castro, Gonzalo M.
Sicilia, Paola
Cecchetto, Eugenio
Lopez, Laura
Scruzzi, Graciela
Barbero, Paula
Diaz, Maria del Pilar
Babas, Maria Gabriela
Re, Viviana
Pisano, Maria Belen
author_sort D´Augero, Leticia
title SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
title_short SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
title_full SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
title_fullStr SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
title_full_unstemmed SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine
title_sort sars-cov-2 circulation in pregnant women from central argentina: mortality rate, infecting variants and a positive impact of the vaccine
description Introduction: SARS-CoV-2 can lead to a more severe infection during pregnancy. However, population-level data on COVID-19 disease and vaccine uptake in this population group are lacking, especially in South America. Objective:We aimed to describe SARS-CoV-2 infection in pregnant women from a central region of Argentina. Methodology:From March-2020 to March-2022, 2407 cases of pregnant women from Córdoba province with confirmed SARS-CoV-2 infection reported in the official records were analyzed. The infectivity and mortality rates were calculated; a control group of non-pregnant women infected with SARS-CoV-2 was included. Sixty-six samples were subjected to variants of concern (VOC) detection by real time RT-PCR. Results:The overall infection rate was 0.25%, and the number of infections mirrored the number of cases for general population. In September-2021 (when mass vaccination in pregnant women occurred) the infection rate decreased (0.35% in March 2020-September 2021 vs. 0.14% in October 2021-March 2022). The global fatality rate was 0.75% (18/2407). During March-2020 to September-2021 the fatality rate was higher than in the control group: 1.01% vs. 0.08% (p<0.05). Since then, no deaths were recorded in pregnant women (fatality rate 0% vs. 0.01% in the control group). The VOCs distribution was: Gamma: 56%, Delta: 20%, Omicron: 12%, Alpha: 3%, 9% of non-VOC lineages.Conclusions:The fatality rate found was similar to that obtained for the entire country in this group, and higher than the control group. The frequency of VOCs reflected what happened in the general population. The decrease in cases and deaths since September-2021 correlated with the mass vaccination in this group.
publisher Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
publishDate 2025
url https://revistas.unc.edu.ar/index.php/med/article/view/45927
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spelling I10-R327-article-459272025-06-26T19:09:18Z SARS-CoV-2 circulation in pregnant women from central Argentina: mortality rate, infecting variants and a positive impact of the vaccine Circulación del SARS-CoV-2 en embarazadas del centro de Argentina: tasa de mortalidad, variantes infectantes e impacto positivo de la vacuna Circulação do SARS-CoV-2 em gestantes da Argentina central: taxa de mortalidade, variantes infectantes e impacto positivo da vacina D´Augero, Leticia Castro, Gonzalo M. Sicilia, Paola Cecchetto, Eugenio Lopez, Laura Scruzzi, Graciela Barbero, Paula Diaz, Maria del Pilar Babas, Maria Gabriela Re, Viviana Pisano, Maria Belen sars-cov-2 covid-19 pregnancy Argentina epidemiology sars-cov-2 covid-19 embarazo Argentina epidemioligia sars-cov-2 covid-19 gravidez Argentina epidemiologia Introduction: SARS-CoV-2 can lead to a more severe infection during pregnancy. However, population-level data on COVID-19 disease and vaccine uptake in this population group are lacking, especially in South America. Objective:We aimed to describe SARS-CoV-2 infection in pregnant women from a central region of Argentina. Methodology:From March-2020 to March-2022, 2407 cases of pregnant women from Córdoba province with confirmed SARS-CoV-2 infection reported in the official records were analyzed. The infectivity and mortality rates were calculated; a control group of non-pregnant women infected with SARS-CoV-2 was included. Sixty-six samples were subjected to variants of concern (VOC) detection by real time RT-PCR. Results:The overall infection rate was 0.25%, and the number of infections mirrored the number of cases for general population. In September-2021 (when mass vaccination in pregnant women occurred) the infection rate decreased (0.35% in March 2020-September 2021 vs. 0.14% in October 2021-March 2022). The global fatality rate was 0.75% (18/2407). During March-2020 to September-2021 the fatality rate was higher than in the control group: 1.01% vs. 0.08% (p<0.05). Since then, no deaths were recorded in pregnant women (fatality rate 0% vs. 0.01% in the control group). The VOCs distribution was: Gamma: 56%, Delta: 20%, Omicron: 12%, Alpha: 3%, 9% of non-VOC lineages.Conclusions:The fatality rate found was similar to that obtained for the entire country in this group, and higher than the control group. The frequency of VOCs reflected what happened in the general population. The decrease in cases and deaths since September-2021 correlated with the mass vaccination in this group. Introducción: El SARS-CoV-2 puede provocar una infección más grave durante el embarazo. Sin embargo, faltan datos a nivel poblacional sobre COVID-19 y la adopción de vacunas en este grupo de población, especialmente en América del Sur. Objetivo: describir la infección por SARS-CoV-2 en mujeres embarazadas de la región central de Argentina. Metodología: se analizaron 2.407 casos de gestantes de Córdoba entre marzo-2020 y marzo-2022 con infección confirmada por SARS-CoV-2 reportados en registros oficiales. Se calcularon tasas de infección y mortalidad; incluyéndose un grupo control de mujeres no embarazadas infectadas con SARS-CoV-2. Sesenta y seis muestras se sometieron a detección de variantes de preocupación (VOC) mediante RT-PCR en tiempo real. Resultados: tasa de infección: 0,25%; el número de infecciones reflejó el número de casos de población general. En septiembre-2021 (momento de vacunación masiva en embarazadas) la tasa de infección disminuyó (0,35% en marzo-2020-septiembre-2021 vs. 0,14% en octubre-2021-marzo-2022). La tasa de letalidad global fue 0,75% (18/2407). Durante marzo-2020 a septiembre-2021 la tasa de letalidad fue mayor que en el grupo control: 1,01% vs 0,08% (p<0,05). Luego no se registraron muertes de embarazadas. Distribución de VOCs: Gamma: 56 %, Delta: 20 %, Omicron: 12 %, Alfa: 3 %, 9 % de linajes no VOC.Conclusiones:La letalidad fue similar a la obtenida para todo el país en este grupo, y superior al grupo control. La frecuencia de VOC reflejó lo que sucedió en la población general. La disminución de casos y muertes desde septiembre de 2021 se correlacionó con la vacunación masiva en este grupo. Introdução: O SARS-CoV-2 pode levar a uma infecção mais grave durante a gravidez. No entanto, faltam dados em nível populacional sobre a doença COVID-19 e a aceitação da vacina neste grupo populacional, especialmente na América do Sul. Objetivo: Nosso objetivo foi descrever a infecção por SARS-CoV-2 em mulheres grávidas de uma região central da Argentina. Metodologia: De março de 2020 a março de 2022, foram analisados ​​2.407 casos de mulheres grávidas da província de Córdoba com infecção confirmada por SARS-CoV-2 relatada nos registros oficiais. As taxas de infectividade e mortalidade foram calculadas; um grupo controle de mulheres não grávidas infectadas com SARS-CoV-2 foi incluído. Sessenta e seis amostras foram submetidas à detecção de variantes preocupantes (VOC) por RT-PCR em tempo real. Resultados: A taxa geral de infecção foi de 0,25%, e o número de infecções refletiu o número de casos para a população em geral. Em setembro de 2021 (quando ocorreu a vacinação em massa em gestantes) a taxa de infecção diminuiu (0,35% em março de 2020-setembro de 2021 vs. 0,14% em outubro de 2021-março de 2022). A taxa de letalidade global foi de 0,75% (18/2407). Durante março de 2020 a setembro de 2021 a taxa de letalidade foi maior que no grupo controle: 1,01% vs. 0,08% (p<0,05). Desde então, nenhuma morte foi registrada em gestantes (taxa de letalidade 0% vs. 0,01% no grupo controle). A distribuição dos COVs foi: Gama: 56%, Delta: 20%, Ômicron: 12%, Alfa: 3%, 9% de linhagens não COV.Conclusões:A taxa de letalidade encontrada foi semelhante à obtida para todo o país neste grupo, e maior que o grupo controle. A frequência de VOCs refletiu o que aconteceu na população em geral. A diminuição de casos e mortes desde setembro de 2021 correlacionou-se com a vacinação em massa neste grupo. Universidad Nacional Córdoba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología 2025-06-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion text/html application/pdf https://revistas.unc.edu.ar/index.php/med/article/view/45927 10.31053/1853.0605.v82.n2.45927 Revista de la Facultad de Ciencias Médicas de Córdoba.; ##issue.vol## 82 ##issue.no## 2 (2025); 287-302 Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 82 Núm. 2 (2025); 287-302 Revista da Faculdade de Ciências Médicas de Córdoba; v. 82 n. 2 (2025); 287-302 1853-0605 0014-6722 10.31053/1853.0605.v82.n2 eng https://revistas.unc.edu.ar/index.php/med/article/view/45927/49108 https://revistas.unc.edu.ar/index.php/med/article/view/45927/49109 Derechos de autor 2025 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0