First autochthonous Hepatitis E cases in Uruguay
In order to describe the first autochthonous Hepatitis E cases, we carried out a descriptive study. The population, 9 patients, was identified from November 2009 to July 2010. They were selected by specific IgG and IgM for HEV and we made viral RNA search in serum by RT-PCR. Patients average age was...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC
2014
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| Acceso en línea: | https://revistas.unc.edu.ar/index.php/RSD/article/view/7007 |
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I10-R360-article-70072025-04-03T12:07:39Z First autochthonous Hepatitis E cases in Uruguay Primeros casos autóctonos de hepatitis E en Uruguay Russi, J.C. Vacarezza, M. Vignolo, J.C. Mirazo, S. Kleist, P. Lissman, S. Parrillo, S. Silvariño, R. Stanham, J. Cohen, H. Hepatitis E Emerging Disease Autochthonous Cases Hepatitis E Enfermedad Emergente Casos Autóctonos In order to describe the first autochthonous Hepatitis E cases, we carried out a descriptive study. The population, 9 patients, was identified from November 2009 to July 2010. They were selected by specific IgG and IgM for HEV and we made viral RNA search in serum by RT-PCR. Patients average age was 51 years old, 8 male, tertiary education, upper middle socioeconomic level, health attention in private sector and urban residence. Clinic results similar to hepatitis A, with elevated transaminases over 1500 (mU/ml) and glutamic pyruvic with maximum values of 5270 (mU/ml). All patients presented hyperbilirubinemia (direct predominance) and increased gamma glutamyl transferase and alkaline phosphatase.Circulation of HEV with clinical manifestations was demonstrated in Uruguay, this shows the presence of an emergent disease. We suggest introducing a formalized HEV diagnosis in patients without etiologic diagnosis of hepatitis. Con el objetivo de describir los primeros casos autóctonos de Hepatitis E se realizó un estudio descriptivo. La población, 9 enfermos, se identificó en el periodo noviembre 2009 a julio 2010. Se seleccionaron por IgG e IgM específicas para VHE y se realizó búsqueda de ARN viral en suero por RT-PCR. Presentaron una media de 51 años, 8 del sexo masculino, educación terciaria, nivel socioeconómico medio alto, atención en el sector privado y residencia urbana. La clínica fue similar a Hepatitis A, con transaminasas elevadas por encima de 1500 (mU/ml), la glutamicopiruvica con valores máximos de 5270 (mU/ml). Todos presentaron hiperbilirrubinemia a predominio directa, aumento de la gamaglutamil transferasa y de Fosfatasa Alcalina. Se demostró circulación en Uruguay del VHE con manifestaciones clínicas, lo que traduce la presencia de una enfermedad emergente.Se plantea introducir el diagnostico del VHE en forma protocolizada en pacientes sin diagnostico etiológico de hepatitis. Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC 2014-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unc.edu.ar/index.php/RSD/article/view/7007 10.31052/1853.1180.v15.n1.7007 Revista de Salud Pública; Vol. 15 Núm. 1 (2011); 6-16 1852-9429 1853-1180 10.31052/1853.1180.v15.n1 spa https://revistas.unc.edu.ar/index.php/RSD/article/view/7007/8073 Derechos de autor 1969 Universidad Nacional de Córdoba https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional de Córdoba |
| institution_str |
I-10 |
| repository_str |
R-360 |
| container_title_str |
Revista de Salud Pública |
| language |
Español |
| format |
Artículo revista |
| topic |
Hepatitis E Emerging Disease Autochthonous Cases Hepatitis E Enfermedad Emergente Casos Autóctonos |
| spellingShingle |
Hepatitis E Emerging Disease Autochthonous Cases Hepatitis E Enfermedad Emergente Casos Autóctonos Russi, J.C. Vacarezza, M. Vignolo, J.C. Mirazo, S. Kleist, P. Lissman, S. Parrillo, S. Silvariño, R. Stanham, J. Cohen, H. First autochthonous Hepatitis E cases in Uruguay |
| topic_facet |
Hepatitis E Emerging Disease Autochthonous Cases Hepatitis E Enfermedad Emergente Casos Autóctonos |
| author |
Russi, J.C. Vacarezza, M. Vignolo, J.C. Mirazo, S. Kleist, P. Lissman, S. Parrillo, S. Silvariño, R. Stanham, J. Cohen, H. |
| author_facet |
Russi, J.C. Vacarezza, M. Vignolo, J.C. Mirazo, S. Kleist, P. Lissman, S. Parrillo, S. Silvariño, R. Stanham, J. Cohen, H. |
| author_sort |
Russi, J.C. |
| title |
First autochthonous Hepatitis E cases in Uruguay |
| title_short |
First autochthonous Hepatitis E cases in Uruguay |
| title_full |
First autochthonous Hepatitis E cases in Uruguay |
| title_fullStr |
First autochthonous Hepatitis E cases in Uruguay |
| title_full_unstemmed |
First autochthonous Hepatitis E cases in Uruguay |
| title_sort |
first autochthonous hepatitis e cases in uruguay |
| description |
In order to describe the first autochthonous Hepatitis E cases, we carried out a descriptive study. The population, 9 patients, was identified from November 2009 to July 2010. They were selected by specific IgG and IgM for HEV and we made viral RNA search in serum by RT-PCR. Patients average age was 51 years old, 8 male, tertiary education, upper middle socioeconomic level, health attention in private sector and urban residence. Clinic results similar to hepatitis A, with elevated transaminases over 1500 (mU/ml) and glutamic pyruvic with maximum values of 5270 (mU/ml). All patients presented hyperbilirubinemia (direct predominance) and increased gamma glutamyl transferase and alkaline phosphatase.Circulation of HEV with clinical manifestations was demonstrated in Uruguay, this shows the presence of an emergent disease. We suggest introducing a formalized HEV diagnosis in patients without etiologic diagnosis of hepatitis. |
| publisher |
Escuela de Salud Pública y Ambiente. Fac. Cs. Médicas UNC |
| publishDate |
2014 |
| url |
https://revistas.unc.edu.ar/index.php/RSD/article/view/7007 |
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