The immunological effect of hyaluronan in tumor angiogenesis

The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neova...

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Detalles Bibliográficos
Autores principales: Spinelli, Fiorella M, Vitale, Daiana L, Demarchi, Gianina, Cristina, Carolina, Alaniz, Laura
Otros Autores: https://orcid.org/0000-0002-6070-6078
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: Wiley-Blackwell 2020
Materias:
Hyaluronan
Acceso en línea:http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/111
Aporte de:
Re DI Repositorio Digital UNNOBA de Universidad Nacional del Noroeste de la Provincia de Buenos Aires
id I103-R405-23601-111
record_format dspace
institution Universidad Nacional del Noroeste de la Provincia de Buenos Aires
institution_str I-103
repository_str R-405
collection Re DI Repositorio Digital UNNOBA
language Inglés
topic Hyaluronan
spellingShingle Hyaluronan
Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
The immunological effect of hyaluronan in tumor angiogenesis
topic_facet Hyaluronan
description The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients.
author2 https://orcid.org/0000-0002-6070-6078
author_facet https://orcid.org/0000-0002-6070-6078
Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
format Artículo
Artículo
publishedVersion
Artículo
Artículo
publishedVersion
Artículo
Artículo
publishedVersion
author Spinelli, Fiorella M
Vitale, Daiana L
Demarchi, Gianina
Cristina, Carolina
Alaniz, Laura
author_sort Spinelli, Fiorella M
title The immunological effect of hyaluronan in tumor angiogenesis
title_short The immunological effect of hyaluronan in tumor angiogenesis
title_full The immunological effect of hyaluronan in tumor angiogenesis
title_fullStr The immunological effect of hyaluronan in tumor angiogenesis
title_full_unstemmed The immunological effect of hyaluronan in tumor angiogenesis
title_sort immunological effect of hyaluronan in tumor angiogenesis
publisher Wiley-Blackwell
publishDate 2020
url http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/111
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spelling I103-R405-23601-1112025-10-21T21:02:55Z The immunological effect of hyaluronan in tumor angiogenesis Spinelli, Fiorella M Vitale, Daiana L Demarchi, Gianina Cristina, Carolina Alaniz, Laura https://orcid.org/0000-0002-6070-6078 https://orcid.org/0000-0003-2727-7504 https://orcid.org/0000-0001-5593-9101 https://orcid.org/0000-0001-8451-7055 Hyaluronan The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients. Fil: Spinelli, Fiorella M. Consejo Nacional de Investigaciones Científicas y Técnica (CONICET). CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina. Fil: Spinelli, Fiorella M. Universidad Nacional del Noroeste de la Provincia. de Buenos Aires (UNNOBA). Centro de Investigaciones Básicas y Aplicadas (CIBA). Laboratorio de Microambiente Tumoral; Argentina. Fil: Vitale, Daiana L. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina. Fil: Vitale, Daiana L. Consejo Nacional de Investigaciones Científicas y Técnica. CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina. Fil: Demarchi, Gianina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Fisiopatología de la Hipófisis; Argentina. Fil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnica. CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina. Fil: Cristina, Carolina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Fisiopatología de la Hipófisis; Argentina. Fil: Cristina, Carolina. Consejo Nacional de Investigaciones Científicas y Técnica. CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina. Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicada. Laboratorio de Microambiente Tumoral; Argentina. Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnica. CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina. Con referato 2020-12-23T14:20:08Z 2020-12-23T14:20:08Z 2015-12-04 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion Spinelli FM, Vitale DL, Demarchi G, Cristina C, Alaniz L. The immunological effect of hyaluronan in tumor angiogenesis. Clin Transl Immunology. 2015;4(12):e52. Published 2015 Dec 4. doi:10.1038/cti.2015.35 2050-0068 http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/111 eng info:eu-repo/grantAgreemen/tSUBSIDIOS FLORENCIO FIORINI PARA INVESTIGACIÓN EN CIENCIAS BIOMEDICAS/2014 /AR. Ciudad de Autónoma de Buenos Aires/Red COES de Repositorios de Acceso Abierto/RCOESRAA doi: 10.1038/cti.2015.35. info:eu-repo/semantics/closedAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf Wiley-Blackwell Clinical & Translational Immunology

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