Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug resistance proteins, active DNA repair capacity, apoptosis resistance, and a consid...
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| Autores principales: | , , , , , , |
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| Formato: | Artículo publishedVersion |
| Lenguaje: | Inglés |
| Publicado: |
2023
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| Acceso en línea: | http://repositorio.unnoba.edu.ar/xmlui/handle/23601/634 |
| Aporte de: |
| id |
I103-R405-23601-634 |
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| record_format |
dspace |
| institution |
Universidad Nacional del Noroeste de la Provincia de Buenos Aires |
| institution_str |
I-103 |
| repository_str |
R-405 |
| collection |
Re DI Repositorio Digital UNNOBA |
| language |
Inglés |
| topic |
Cancer stem cell CD44 Chemotherapy CSPG4 Heparan sulfate Hyaluronan Proteoglycan Radiation Stem cell niche Syndecan |
| spellingShingle |
Cancer stem cell CD44 Chemotherapy CSPG4 Heparan sulfate Hyaluronan Proteoglycan Radiation Stem cell niche Syndecan Vitale, Daiana Luján Katakam, Sampath Kumar Greve, Burkhard Jang, Bohee Oh, Eok-Soo Alaniz, Laura Gotte, Martin Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| topic_facet |
Cancer stem cell CD44 Chemotherapy CSPG4 Heparan sulfate Hyaluronan Proteoglycan Radiation Stem cell niche Syndecan |
| description |
In contrast to the bulk of the tumor, a subset of cancer cells called cancer
stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal,
unlimited proliferative potential, expression of multidrug resistance proteins,
active DNA repair capacity, apoptosis resistance, and a considerable developmental
plasticity. Due to these properties, CSCs display increased resistance
to chemo- and radiotherapy. Recent findings indicate that aberrant
functions of proteoglycans (PGs) and glycosaminoglycans (GAGs) contribute
substantially to the CSC phenotype and therapeutic resistance. In this
review, we summarize how the diverse functions of the glycoproteins and
carbohydrates facilitate acquisition and maintenance of the CSC phenotype,
and how this knowledge can be exploited to develop novel anticancer therapies.
For example, the large transmembrane chondroitin sulfate PG NG2/
CSPG4 marks stem cell (SC) populations in brain tumors. Cell surface heparan
sulfate PGs of the syndecan and glypican families modulate the stemness-
associated Wnt, hedgehog, and notch signaling pathways, whereas the
interplay of hyaluronan in the SC niche with CSC CD44 determines the
maintenance of stemness and promotes therapeutic resistance. A better
understanding of the molecular mechanisms by which PGs and GAGs regulate
CSC function will aid the development of targeted therapeutic
approaches which could avoid relapse after an otherwise successful conventional
therapy. Chimeric antigen receptor T cells, PG-primed dendritic cells,
PG-targeted antibody–drug conjugates, and inhibitory peptides and glycans
have already shown highly promising results in preclinical models. |
| author2 |
0000-0001-5593-9101 |
| author_facet |
0000-0001-5593-9101 Vitale, Daiana Luján Katakam, Sampath Kumar Greve, Burkhard Jang, Bohee Oh, Eok-Soo Alaniz, Laura Gotte, Martin |
| format |
Artículo Artículo publishedVersion Artículo Artículo publishedVersion Artículo Artículo publishedVersion |
| author |
Vitale, Daiana Luján Katakam, Sampath Kumar Greve, Burkhard Jang, Bohee Oh, Eok-Soo Alaniz, Laura Gotte, Martin |
| author_sort |
Vitale, Daiana Luján |
| title |
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| title_short |
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| title_full |
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| title_fullStr |
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| title_full_unstemmed |
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| title_sort |
proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance |
| publishDate |
2023 |
| url |
http://repositorio.unnoba.edu.ar/xmlui/handle/23601/634 |
| work_keys_str_mv |
AT vitaledaianalujan proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT katakamsampathkumar proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT greveburkhard proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT jangbohee proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT oheoksoo proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT alanizlaura proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance AT gottemartin proteoglycansandglycosaminoglycansasregulatorsofcancerstemcellfunctionandtherapeuticresistance |
| _version_ |
1850060828004319232 |
| spelling |
I103-R405-23601-6342025-10-21T21:11:39Z Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance Vitale, Daiana Luján Katakam, Sampath Kumar Greve, Burkhard Jang, Bohee Oh, Eok-Soo Alaniz, Laura Gotte, Martin 0000-0001-5593-9101 0000-0002-6070-6078 0000-0003-2360-2496 Cancer stem cell CD44 Chemotherapy CSPG4 Heparan sulfate Hyaluronan Proteoglycan Radiation Stem cell niche Syndecan In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug resistance proteins, active DNA repair capacity, apoptosis resistance, and a considerable developmental plasticity. Due to these properties, CSCs display increased resistance to chemo- and radiotherapy. Recent findings indicate that aberrant functions of proteoglycans (PGs) and glycosaminoglycans (GAGs) contribute substantially to the CSC phenotype and therapeutic resistance. In this review, we summarize how the diverse functions of the glycoproteins and carbohydrates facilitate acquisition and maintenance of the CSC phenotype, and how this knowledge can be exploited to develop novel anticancer therapies. For example, the large transmembrane chondroitin sulfate PG NG2/ CSPG4 marks stem cell (SC) populations in brain tumors. Cell surface heparan sulfate PGs of the syndecan and glypican families modulate the stemness- associated Wnt, hedgehog, and notch signaling pathways, whereas the interplay of hyaluronan in the SC niche with CSC CD44 determines the maintenance of stemness and promotes therapeutic resistance. A better understanding of the molecular mechanisms by which PGs and GAGs regulate CSC function will aid the development of targeted therapeutic approaches which could avoid relapse after an otherwise successful conventional therapy. Chimeric antigen receptor T cells, PG-primed dendritic cells, PG-targeted antibody–drug conjugates, and inhibitory peptides and glycans have already shown highly promising results in preclinical models. Fil: Vitale, Daiana Luján. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina. Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina. Fil: Katakam, Sampath Kumar. Munster University. Munster University Hospital. Department of Gynecology and Obstetrics; Alemania. Fil: Greve, Burkhard. Munster University. Munster University Hospital. Department of Radiotherapy – Radiooncology; Alemania. Fil: Jang, Bohee. Ewha Womans University. Department of Life Sciences. The Research Center for Cellular Homeostasis; Corea. Fil: Oh, Eok-Soo. Ewha Womans University. Department of Life Sciences. The Research Center for Cellular Homeostasis; Corea. Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina. Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina. Fil: Gotte, Martin. Munster University. Munster University Hospital. Department of Gynecology and Obstetrics; Alemania. Con referato 2023-12-04T19:18:39Z 2023-12-04T19:18:39Z 2019-06-19 info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article info:ar-repo/semantics/artículo info:eu-repo/semantics/publishedVersion Vitale D., Kumar Katakam S., Greve B., Jang B., Oh E. S.Alaniz L., Götte M. (2019). Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance. The FEBS Journal, 286(15), 2870-2882 1742-4658 http://repositorio.unnoba.edu.ar/xmlui/handle/23601/634 eng eu-repo/grantAgreement/European Comission/H2020 RISE-MSCA Project/645,756/GLYCANC doi:10.1111/febs.14967 info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf application/vnd.openxmlformats-officedocument.wordprocessingml.document The FEBS Journal |