The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma

There is growing evidence that supports the role of the tumor microenvironment in the development and progression of hepatocellular carcinoma. The tumor microenvironment is composed of cellular components, bioactive substances, and extracellular matrix comprising of proteins such as collagens, pro...

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Autores principales: Sevic, Ina, Spinelli, Fiorella Mercedes, Cantero, María José, Reszegi, Andrea, Kovalszky, Ilona, García, Mariana Gabriela, Alaniz, Laura
Otros Autores: Tirnitz-Parker, Janina E.E.
Formato: Book chapter
Lenguaje:Inglés
Publicado: Codon Publications 2023
Materias:
Hepatocellular carcinoma
Hyaluronic acid
Macrophages
Mesenchymal stem cells
Tumor microenvironment
Acceso en línea:http://repositorio.unnoba.edu.ar/xmlui/handle/23601/667
Aporte de:
Re DI Repositorio Digital UNNOBA de Universidad Nacional del Noroeste de la Provincia de Buenos Aires
id I103-R405-23601-667
record_format dspace
spelling I103-R405-23601-6672023-12-18T19:54:30Z The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma Sevic, Ina Spinelli, Fiorella Mercedes Cantero, María José Reszegi, Andrea Kovalszky, Ilona García, Mariana Gabriela Alaniz, Laura Tirnitz-Parker, Janina E.E. Hepatocellular carcinoma Hyaluronic acid Macrophages Mesenchymal stem cells Tumor microenvironment There is growing evidence that supports the role of the tumor microenvironment in the development and progression of hepatocellular carcinoma. The tumor microenvironment is composed of cellular components, bioactive substances, and extracellular matrix comprising of proteins such as collagens, proteoglycans, and the linear glycosaminoglycan hyaluronan. Hepatocellular carcinoma generally arises from fibrotic or cirrhotic liver, characterized by alterationin extracellular matrix components. In addition, non-tumoral cells such as mesenchymal stem/stromal cells (MSCs) are typically recruited to the injured or hypoxic area within the tumor. Besides the secretion of immunoregulatory proteins, growth factors, and cytokines, MSCs and hepatic stellate cells can also synthesize hyaluronan, amongst other components, which affects several tumor-associated processes. The tumor microenvironment also contains different types of immune cells. A key component in the genesis of hepatocellular carcinoma is the macrophages, as tumor-associated macrophages (TAM). This chapter provides an overview of the interaction of MSCshyaluronan-TAMs and tumor cells, and how this interaction potentially contributes to the development and progression of hepatocellular carcinoma. Fil: Sevic, Ina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina Fil: Sevic, Ina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina Fil: Spinelli, Fiorella Mercedes. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina Fil: Spinelli, Fiorella Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina Fil: Cantero, María José. Universidad Austral. IIMT–CONICET. Laboratorio de Terapia Génica; Argentina Fil: Reszegi, Andrea. Semmelweis University. Department of Pathology and Experimental Cancer Research; Hungría Fil: Kovalszky, Ilona. Semmelweis University. Department of Pathology and Experimental Cancer Research; Hungría Fil: García, Mariana. Universidad Austral. IIMT–CONICET. Laboratorio de Terapia Génica; Argentina Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina 2023-12-18T19:53:31Z 2023-12-18T19:53:31Z 2019-10-09 Book chapter Sevic, I., Spinelli, F. M., Cantero, M. J., Reszegi, A., Kovalszky, I., García, M. G. y Alaniz L. (2019). The role of the tumor microenvironment in the development and progression of hepatocellular carcinoma. En Hepatocellular Carcinoma (pp. 29–45). Codon Publications. 978-0-9944381-8-8 http://repositorio.unnoba.edu.ar/xmlui/handle/23601/667 eng eu-repo/grantAgreement/UNNOBA/SIB 2019/0561-2019 eu-repo/grantAgreement/ ANPCyT/PICTO/2019-00011 https://doi.org/10.15586/hepatocellularcarcinoma.2019.ch2 https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf application/pdf Codon Publications Hepatocellular carcinoma
institution Universidad Nacional del Noroeste de la Provincia de Buenos Aires
institution_str I-103
repository_str R-405
collection Re DI Repositorio Digital UNNOBA
language Inglés
topic Hepatocellular carcinoma
Hyaluronic acid
Macrophages
Mesenchymal stem cells
Tumor microenvironment
spellingShingle Hepatocellular carcinoma
Hyaluronic acid
Macrophages
Mesenchymal stem cells
Tumor microenvironment
Sevic, Ina
Spinelli, Fiorella Mercedes
Cantero, María José
Reszegi, Andrea
Kovalszky, Ilona
García, Mariana Gabriela
Alaniz, Laura
The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
topic_facet Hepatocellular carcinoma
Hyaluronic acid
Macrophages
Mesenchymal stem cells
Tumor microenvironment
description There is growing evidence that supports the role of the tumor microenvironment in the development and progression of hepatocellular carcinoma. The tumor microenvironment is composed of cellular components, bioactive substances, and extracellular matrix comprising of proteins such as collagens, proteoglycans, and the linear glycosaminoglycan hyaluronan. Hepatocellular carcinoma generally arises from fibrotic or cirrhotic liver, characterized by alterationin extracellular matrix components. In addition, non-tumoral cells such as mesenchymal stem/stromal cells (MSCs) are typically recruited to the injured or hypoxic area within the tumor. Besides the secretion of immunoregulatory proteins, growth factors, and cytokines, MSCs and hepatic stellate cells can also synthesize hyaluronan, amongst other components, which affects several tumor-associated processes. The tumor microenvironment also contains different types of immune cells. A key component in the genesis of hepatocellular carcinoma is the macrophages, as tumor-associated macrophages (TAM). This chapter provides an overview of the interaction of MSCshyaluronan-TAMs and tumor cells, and how this interaction potentially contributes to the development and progression of hepatocellular carcinoma.
author2 Tirnitz-Parker, Janina E.E.
author_facet Tirnitz-Parker, Janina E.E.
Sevic, Ina
Spinelli, Fiorella Mercedes
Cantero, María José
Reszegi, Andrea
Kovalszky, Ilona
García, Mariana Gabriela
Alaniz, Laura
format Book chapter
author Sevic, Ina
Spinelli, Fiorella Mercedes
Cantero, María José
Reszegi, Andrea
Kovalszky, Ilona
García, Mariana Gabriela
Alaniz, Laura
author_sort Sevic, Ina
title The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
title_short The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
title_full The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
title_fullStr The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
title_full_unstemmed The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma
title_sort role of the tumor microenvironment in the development and progression of hepatocellular carcinoma
publisher Codon Publications
publishDate 2023
url http://repositorio.unnoba.edu.ar/xmlui/handle/23601/667
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