Radical oxygen species and bile secretion

Oxidative stress is a common feature in most hepatopathies. Accumulating evidences indicate that reactive oxygen species (ROS) induce a number of functional changes either deleterious or adaptive in the capability of the hepatocytes to produce bile and to secrete exogenous and endogenous compounds....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Basiglio, Cecilia Lorena, Toledo, Flavia D., Sánchez Pozzi, Enrique J., Roma, Marcelo Gabriel
Formato:	bookPart parte de libro acceptedVersion
Lenguaje:	Inglés
Publicado:	Springer 2019
Materias:	Canalicular transporters Oxidative Stress Bile Secretion Signalling Cholestasis Protein kinases Tight junctions
Acceso en línea:	http://hdl.handle.net/2133/14092 http://hdl.handle.net/2133/14092
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-14092
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	Canalicular transporters Oxidative Stress Bile Secretion Signalling Cholestasis Protein kinases Tight junctions
spellingShingle	Canalicular transporters Oxidative Stress Bile Secretion Signalling Cholestasis Protein kinases Tight junctions Basiglio, Cecilia Lorena Toledo, Flavia D. Sánchez Pozzi, Enrique J. Roma, Marcelo Gabriel Radical oxygen species and bile secretion
topic_facet	Canalicular transporters Oxidative Stress Bile Secretion Signalling Cholestasis Protein kinases Tight junctions
description	Oxidative stress is a common feature in most hepatopathies. Accumulating evidences indicate that reactive oxygen species (ROS) induce a number of functional changes either deleterious or adaptive in the capability of the hepatocytes to produce bile and to secrete exogenous and endogenous compounds. This review is aimed to describe the mechanisms involved in these changes. For this purpose, we will summarize: 1. The current evidence that acutely induced oxidative stress is cholestatic, by describing the mechanisms underlying the hepatocyte secretory failure, including the disorganization of the actin cytoskeleton and its most noticeable consequences, that is, the impairment of tight-junctional structures and the endocytic internalization of canalicular transporters relevant to bile formation. 2. The role for oxidative-stress-activated signalling pathways in the pathomechanisms described above, particularly those involving Ca2+ elevation and its consequent activation via Ca2+ of “classical” and “novel” PKC isoforms. 3. The mechanisms involved in the adaptive response against oxidative stress mediated by ROS-responsive transcription factors, such as upregulation of GSH synthesis pathway, antioxidant enzymes, and hepatocellular efflux pumps. 4. The consequences on hepatocellular secretory function when this adaptive response can be surpassed by the sustained/high production of ROS. This deleterious effects include transcriptional and posttranscriptional changes in the expression of transporters relevant to bile formation, as has been shown to occur, for example, after long-term administration of aluminum to rats, in the Long-Evans Cinnamon rat (a model of chronic hepatic copper accumulation mimicking Wilson’s disease), and in ischemia-reperfusion injury.
format	bookPart parte de libro acceptedVersion
author	Basiglio, Cecilia Lorena Toledo, Flavia D. Sánchez Pozzi, Enrique J. Roma, Marcelo Gabriel
author_facet	Basiglio, Cecilia Lorena Toledo, Flavia D. Sánchez Pozzi, Enrique J. Roma, Marcelo Gabriel
author_sort	Basiglio, Cecilia Lorena
title	Radical oxygen species and bile secretion
title_short	Radical oxygen species and bile secretion
title_full	Radical oxygen species and bile secretion
title_fullStr	Radical oxygen species and bile secretion
title_full_unstemmed	Radical oxygen species and bile secretion
title_sort	radical oxygen species and bile secretion
publisher	Springer
publishDate	2019
url	http://hdl.handle.net/2133/14092 http://hdl.handle.net/2133/14092
work_keys_str_mv	AT basigliocecilialorena radicaloxygenspeciesandbilesecretion AT toledoflaviad radicaloxygenspeciesandbilesecretion AT sanchezpozzienriquej radicaloxygenspeciesandbilesecretion AT romamarcelogabriel radicaloxygenspeciesandbilesecretion
bdutipo_str	Repositorios
_version_	1764820408190631936

Radical oxygen species and bile secretion

Ejemplares similares