Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones

Herein it is provided an efficient, environmentally friendly and one-pot procedure for the synthesis of a library of new and diversely substituted 1,3-thiazolidin-4-ones in short reaction times and good yields through a solvent-, catalyst- and desiccant-free three-component process. Reactions pro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abonia, Rodrigo, Castillo, Juan, Insuasty, Braulio, Quiroga, Jairo, Sortino, Maximiliano, Nogueras, Manuel, Cobo, Justo
Formato:	article artículo publishedVersion
Lenguaje:	Inglés
Publicado:	Elsevier 2020
Materias:	2-Mercaptoacetic Acid Primary Benzylamines Multicomponent Reactions Solvent-free Conditions Green Synthesis Thiazolidin-4-ones
Acceso en línea:	http://hdl.handle.net/2133/19492 http://hdl.handle.net/2133/19492
Aporte de:	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario

id	I15-R121-2133-19492
record_format	dspace
institution	Universidad Nacional de Rosario
institution_str	I-15
repository_str	R-121
collection	Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language	Inglés
orig_language_str_mv	eng
topic	2-Mercaptoacetic Acid Primary Benzylamines Multicomponent Reactions Solvent-free Conditions Green Synthesis Thiazolidin-4-ones
spellingShingle	2-Mercaptoacetic Acid Primary Benzylamines Multicomponent Reactions Solvent-free Conditions Green Synthesis Thiazolidin-4-ones Abonia, Rodrigo Castillo, Juan Insuasty, Braulio Quiroga, Jairo Sortino, Maximiliano Nogueras, Manuel Cobo, Justo Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
topic_facet	2-Mercaptoacetic Acid Primary Benzylamines Multicomponent Reactions Solvent-free Conditions Green Synthesis Thiazolidin-4-ones
description	Herein it is provided an efficient, environmentally friendly and one-pot procedure for the synthesis of a library of new and diversely substituted 1,3-thiazolidin-4-ones in short reaction times and good yields through a solvent-, catalyst- and desiccant-free three-component process. Reactions proceeded by treatment of primary benzyl(aryl)amines with aromatic aldehydes (and ketones) and 2-mercaptoacetic acid acting as both reagent and self-catalyst. All reactions were performed in sand bath instead of the commonly used oil bath avoiding the generation of undesired volatile materials proceeding of the thermal decomposition of the oils. IR, Mass and NMR experiments as well as Xray diffraction confirmed structures of the obtained products.
format	article artículo publishedVersion
author	Abonia, Rodrigo Castillo, Juan Insuasty, Braulio Quiroga, Jairo Sortino, Maximiliano Nogueras, Manuel Cobo, Justo
author_facet	Abonia, Rodrigo Castillo, Juan Insuasty, Braulio Quiroga, Jairo Sortino, Maximiliano Nogueras, Manuel Cobo, Justo
author_sort	Abonia, Rodrigo
title	Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
title_short	Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
title_full	Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
title_fullStr	Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
title_full_unstemmed	Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones
title_sort	catalyst-, solvent- and desiccant-free three-component synthesis of novel c-2,n-3 disubstituted thiazolidin-4-ones
publisher	Elsevier
publishDate	2020
url	http://hdl.handle.net/2133/19492 http://hdl.handle.net/2133/19492
work_keys_str_mv	AT aboniarodrigo catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT castillojuan catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT insuastybraulio catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT quirogajairo catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT sortinomaximiliano catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT noguerasmanuel catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones AT cobojusto catalystsolventanddesiccantfreethreecomponentsynthesisofnovelc2n3disubstitutedthiazolidin4ones
bdutipo_str	Repositorios
_version_	1764820410888617985

Catalyst-, solvent- and desiccant-free three-component synthesis of novel C-2,N-3 disubstituted thiazolidin-4-ones

Ejemplares similares