Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies

Although the vertebrate head has evolved to a wide collection of adaptive shapes, the fundamental signalling pathways and cellular events that outline the head skeleton have proven to be highly conserved. This conservation suggests that major morphological differences are due to changes in different...

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Autores principales: Weiner, Andrea María Julia, Coux, Gabriela, Armas, Pablo, Calcaterra, Nora
Formato: article artículo publishedVersion
Lenguaje:Inglés
Publicado: UPV/EHU Press 2022
Materias:
Animal Model
Gene Regulatory Network
Epigenetic
Treacher Collins/ Franceschetti Syndrome
Acceso en línea:http://hdl.handle.net/2133/23411
http://hdl.handle.net/2133/23411
Aporte de:
Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR) de Universidad Nacional de Rosario
id I15-R121-2133-23411
record_format dspace
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-121
collection Repositorio Hipermedial de la Universidad Nacional de Rosario (UNR)
language Inglés
orig_language_str_mv eng
topic Animal Model
Gene Regulatory Network
Epigenetic
Treacher Collins/ Franceschetti Syndrome
spellingShingle Animal Model
Gene Regulatory Network
Epigenetic
Treacher Collins/ Franceschetti Syndrome
Weiner, Andrea María Julia
Coux, Gabriela
Armas, Pablo
Calcaterra, Nora
Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
topic_facet Animal Model
Gene Regulatory Network
Epigenetic
Treacher Collins/ Franceschetti Syndrome
description Although the vertebrate head has evolved to a wide collection of adaptive shapes, the fundamental signalling pathways and cellular events that outline the head skeleton have proven to be highly conserved. This conservation suggests that major morphological differences are due to changes in differentiation and morphogenetic programs downstream of a well-maintained developmental prepattern. Here we provide a brief examination of the mechanisms and pathways responsible for vertebrate head development, as well as an overview of the animal models suitable for studying face development. In addition, we describe the criteria for neurocristopathy classification, highlighting the contribution of zebrafish to the modelling of Treacher Collins/Franceschetti Syndrome, an emblematic neurocristopathy. The contributions from our laboratory reveal that proper zebrafish head development depends on the fine-tuning of developmental-gene expression mediated by nucleic acid binding proteins able to regulate DNA conformation and / or the neuroepithelium redox state.
format article
artículo
publishedVersion
author Weiner, Andrea María Julia
Coux, Gabriela
Armas, Pablo
Calcaterra, Nora
author_facet Weiner, Andrea María Julia
Coux, Gabriela
Armas, Pablo
Calcaterra, Nora
author_sort Weiner, Andrea María Julia
title Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
title_short Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
title_full Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
title_fullStr Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
title_full_unstemmed Insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
title_sort insights into vertebrate head development: from cranial neural crest to the modelling of neurocristopathies
publisher UPV/EHU Press
publishDate 2022
url http://hdl.handle.net/2133/23411
http://hdl.handle.net/2133/23411
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AT couxgabriela insightsintovertebrateheaddevelopmentfromcranialneuralcresttothemodellingofneurocristopathies
AT armaspablo insightsintovertebrateheaddevelopmentfromcranialneuralcresttothemodellingofneurocristopathies
AT calcaterranora insightsintovertebrateheaddevelopmentfromcranialneuralcresttothemodellingofneurocristopathies
bdutipo_str Repositorios
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