ICMT as a potential biomarker in cancer

ICMT encodes the third of three enzymes that posttranslationally modify C-terminal cysteine residues in certain proteins. In the last few years, several studies have shown that it may play a role in carcinogenesis. Based on bioinformatics data, we explored its oncogenic role. ICMT expression is wide...

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Autores principales: Arel Zalazar, Evelyn, Cocordano, Nabila, Valente, Sabrina, Girardini, Javier, Borini Etichetti, Carla
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional de Rosario 2022
Materias:
ICMT
carboximetilación
proteínas CAAX
cáncer
carboxymethylation
CAAX proteins
cancer
Acceso en línea:https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/52
Aporte de:
FCM Científica de Universidad Nacional de Rosario
id I15-R235-article-52
record_format ojs
spelling I15-R235-article-522023-11-08T14:27:54Z ICMT as a potential biomarker in cancer ICMT como potencial biomarcador en el cáncer Arel Zalazar, Evelyn Cocordano, Nabila Valente, Sabrina Girardini, Javier Borini Etichetti, Carla ICMT carboximetilación proteínas CAAX cáncer ICMT carboxymethylation CAAX proteins cancer ICMT encodes the third of three enzymes that posttranslationally modify C-terminal cysteine residues in certain proteins. In the last few years, several studies have shown that it may play a role in carcinogenesis. Based on bioinformatics data, we explored its oncogenic role. ICMT expression is widespread in almost all tissues of the body and, in most tumors, it is increased with regard to the corresponding healthy tissues. Furthermore, ICMT overexpression correlates with decreased overall patient survival in a large number of tumor types. From ICMT genetic alteration data, we observed that the proportion of patients with ICMT copy number variations, fusions or mutations is very low. This indicates that its protumoral effects may be associated with changes in its expression level. Altogether, this study provides evidence that underscores the prognostic value and oncogenic role of ICMT in multiple tumor types. ICMT cataliza el último paso de un proceso de modificación postraduccional que afecta residuos de cisteína C-terminal en ciertas proteínas. En los últimos años, varios estudios demostraron que puede desempeñar un papel en la carcinogénesis. Basándonos en datos bioinformáticos, exploramos su rol oncogénico. La expresión de ICMT se encuentra extendida en casi todos los tejidos del organismo y, en la mayoría de los tumores, está incrementada respecto a los correspondientes tejidos sanos. A su vez, la sobreexpresión de ICMT se correlaciona con una menor sobrevida general de los pacientes en un gran número de tumores. A partir de datos de alteración genética de ICMT, observamos que la proporción de pacientes con cambios en el número de copias, fusiones o mutaciones en el mismo es muy baja. Estas observaciones indican que sus efectos protumorales pueden asociarse a cambios en su nivel de expresión. En conjunto, este estudio aporta evidencias que subrayan el valor pronóstico y el papel oncogénico de ICMT en múltiples tipos tumorales. Universidad Nacional de Rosario 2022-07-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/52 10.35305/fcm.v2i.52 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario.; Vol. 2 (2021); 15-28 2796-7719 spa https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/52/56 Derechos de autor 2022 Revista de la Facultad de Ciencias Médicas. Universidad Nacional de Rosario. https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional de Rosario
institution_str I-15
repository_str R-235
container_title_str FCM Científica
language Español
format Artículo revista
topic ICMT
carboximetilación
proteínas CAAX
cáncer
ICMT
carboxymethylation
CAAX proteins
cancer
spellingShingle ICMT
carboximetilación
proteínas CAAX
cáncer
ICMT
carboxymethylation
CAAX proteins
cancer
Arel Zalazar, Evelyn
Cocordano, Nabila
Valente, Sabrina
Girardini, Javier
Borini Etichetti, Carla
ICMT as a potential biomarker in cancer
topic_facet ICMT
carboximetilación
proteínas CAAX
cáncer
ICMT
carboxymethylation
CAAX proteins
cancer
author Arel Zalazar, Evelyn
Cocordano, Nabila
Valente, Sabrina
Girardini, Javier
Borini Etichetti, Carla
author_facet Arel Zalazar, Evelyn
Cocordano, Nabila
Valente, Sabrina
Girardini, Javier
Borini Etichetti, Carla
author_sort Arel Zalazar, Evelyn
title ICMT as a potential biomarker in cancer
title_short ICMT as a potential biomarker in cancer
title_full ICMT as a potential biomarker in cancer
title_fullStr ICMT as a potential biomarker in cancer
title_full_unstemmed ICMT as a potential biomarker in cancer
title_sort icmt as a potential biomarker in cancer
description ICMT encodes the third of three enzymes that posttranslationally modify C-terminal cysteine residues in certain proteins. In the last few years, several studies have shown that it may play a role in carcinogenesis. Based on bioinformatics data, we explored its oncogenic role. ICMT expression is widespread in almost all tissues of the body and, in most tumors, it is increased with regard to the corresponding healthy tissues. Furthermore, ICMT overexpression correlates with decreased overall patient survival in a large number of tumor types. From ICMT genetic alteration data, we observed that the proportion of patients with ICMT copy number variations, fusions or mutations is very low. This indicates that its protumoral effects may be associated with changes in its expression level. Altogether, this study provides evidence that underscores the prognostic value and oncogenic role of ICMT in multiple tumor types.
publisher Universidad Nacional de Rosario
publishDate 2022
url https://fcmcientifica.unr.edu.ar/index.php/revista/article/view/52
work_keys_str_mv AT arelzalazarevelyn icmtasapotentialbiomarkerincancer
AT cocordanonabila icmtasapotentialbiomarkerincancer
AT valentesabrina icmtasapotentialbiomarkerincancer
AT girardinijavier icmtasapotentialbiomarkerincancer
AT borinietichetticarla icmtasapotentialbiomarkerincancer
AT arelzalazarevelyn icmtcomopotencialbiomarcadorenelcancer
AT cocordanonabila icmtcomopotencialbiomarcadorenelcancer
AT valentesabrina icmtcomopotencialbiomarcadorenelcancer
AT girardinijavier icmtcomopotencialbiomarcadorenelcancer
AT borinietichetticarla icmtcomopotencialbiomarcadorenelcancer
first_indexed 2023-06-26T22:51:01Z
last_indexed 2024-08-12T21:45:34Z
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