Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion

This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and gui...

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Autores principales: Consolini, Alicia Elvira, Ragone, María Inés, Colareda, Germán Andrés, Bonazzola, Patricia
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/101003
https://ri.conicet.gov.ar/11336/42000
http://pmr.safisiol.org.ar/archive/id/95
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-101003
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
spellingShingle Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
Consolini, Alicia Elvira
Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
topic_facet Ciencias Médicas
Calorimetry
Cardiac stunning
Sarcoplasmic reticulum
Mitochondria
Calcium
description This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences.
format Articulo
Revision
author Consolini, Alicia Elvira
Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
author_facet Consolini, Alicia Elvira
Ragone, María Inés
Colareda, Germán Andrés
Bonazzola, Patricia
author_sort Consolini, Alicia Elvira
title Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_short Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_full Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_fullStr Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_full_unstemmed Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
title_sort calorimetry of isolated hearts (ii) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/101003
https://ri.conicet.gov.ar/11336/42000
http://pmr.safisiol.org.ar/archive/id/95
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