Calorimetry of isolated hearts (II) energetic of ca 2+ homeostasis in different animal models and during ischemia-reperfusion
This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and gui...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | Articulo Revision |
| Lenguaje: | Inglés |
| Publicado: |
2017
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/101003 https://ri.conicet.gov.ar/11336/42000 http://pmr.safisiol.org.ar/archive/id/95 |
| Aporte de: |
| Sumario: | This review describes the application of calorimetry to study cardiac energetics in physiological, pharmacological and pathophysiological conditions of a perfused heart preparation. In particular, the factors influencing the resting heat rate (Hr), such asspecies differences among rat, mouse and guinea-pig hearts, as well as the mechanismsunderlying the increased resting heat rate under a high [K+]-cardioplegia were discussed. Our results give support to a functional interaction between the sarcoplasmic reticulum and mitochondria for myocardial Ca2+ movements. Finally, it is briefly commented the application of calorimetry to study Ca2+ homeostasis during a model of stunning induced by no-flow ischemia and reperfusion in entire hearts by usingselective inhibitors of cellular Ca2+ transporters. Either in the presence or absence ofperfusion, calorimetry allows to evaluate the total muscle economy. As application, calorimetry allows to detect a cardiac dysfunction still under unaltered contractility, demonstrating that it is a very sensitive methodology for studying pathological situations and pharmacological consequences. |
|---|