Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures

The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlor...

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Autores principales: Bonansea, Rocio Ines, Marino, Damián José Gabriel, Bertrand, Lidwina, Wunderlin, Daniel Alberto, Amé, María Valeria
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/101215
https://ri.conicet.gov.ar/11336/48047
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-101215
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
spellingShingle Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
Bonansea, Rocio Ines
Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
topic_facet Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
description The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.
format Articulo
Articulo
author Bonansea, Rocio Ines
Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
author_facet Bonansea, Rocio Ines
Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
author_sort Bonansea, Rocio Ines
title Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_short Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_full Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_fullStr Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_full_unstemmed Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_sort tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/101215
https://ri.conicet.gov.ar/11336/48047
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