Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering

Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarat...

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Autores principales:	Lastra, María Laura, Molinuevo, María Silvina, Cortizo, Ana María, Cortizo, María Susana
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Física Química Cross-linked polymers Osteochondrogenic tissue
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/103339 https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201600219
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-103339
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Física Química Cross-linked polymers Osteochondrogenic tissue
spellingShingle	Física Química Cross-linked polymers Osteochondrogenic tissue Lastra, María Laura Molinuevo, María Silvina Cortizo, Ana María Cortizo, María Susana Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
topic_facet	Física Química Cross-linked polymers Osteochondrogenic tissue
description	Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
format	Articulo Articulo
author	Lastra, María Laura Molinuevo, María Silvina Cortizo, Ana María Cortizo, María Susana
author_facet	Lastra, María Laura Molinuevo, María Silvina Cortizo, Ana María Cortizo, María Susana
author_sort	Lastra, María Laura
title	Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_short	Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_full	Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_fullStr	Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_full_unstemmed	Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_sort	fumarate copolymer–chitosan cross-linked scaffold directed to osteochondrogenic tissue engineering
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/103339 https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201600219
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bdutipo_str	Repositorios
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Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering

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