The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells

The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <i>Lagostomus maximus</i> to ana...

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Autores principales: Tano de la Hoz, María Florencia, Flamini, Mirta Alicia, Zanuzzi, Carolina Natalia, Díaz, Alcira Ofelia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104820
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104820
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
spellingShingle Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
Tano de la Hoz, María Florencia
Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
topic_facet Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
description The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <i>Lagostomus maximus</i> to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA/Bh/KOH/ PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti-c-kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of <i>L. maximus</i>. Of all types identified, the ICC-SM were the only cells located solely within the colonic groove.
format Articulo
Articulo
author Tano de la Hoz, María Florencia
Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
author_facet Tano de la Hoz, María Florencia
Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
author_sort Tano de la Hoz, María Florencia
title The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_short The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_full The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_fullStr The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_full_unstemmed The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_sort colonic groove of the plains viscacha (<i>lagostomus maximus</i>) : histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104820
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