The Influence of MicroRNAs on Mitochondrial Calcium

Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulat...

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Autores principales: Jaquenod De Giusti, Carolina, Román, Bárbara Soledad, Das, Samarjit
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107839
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6160583&blobtype=pdf
https://www.frontiersin.org/articles/10.3389/fphys.2018.01291/full
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107839
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
spellingShingle Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
Jaquenod De Giusti, Carolina
Román, Bárbara Soledad
Das, Samarjit
The Influence of MicroRNAs on Mitochondrial Calcium
topic_facet Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
description Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca<sup>2+</sup>]<sub>m</sub> uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca<sup>2+</sup>]<sub>m</sub> levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca<sup>2+</sup>]<sub>m</sub> handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca<sup>2+</sup>]<sub>m</sub> handling.
format Articulo
Articulo
author Jaquenod De Giusti, Carolina
Román, Bárbara Soledad
Das, Samarjit
author_facet Jaquenod De Giusti, Carolina
Román, Bárbara Soledad
Das, Samarjit
author_sort Jaquenod De Giusti, Carolina
title The Influence of MicroRNAs on Mitochondrial Calcium
title_short The Influence of MicroRNAs on Mitochondrial Calcium
title_full The Influence of MicroRNAs on Mitochondrial Calcium
title_fullStr The Influence of MicroRNAs on Mitochondrial Calcium
title_full_unstemmed The Influence of MicroRNAs on Mitochondrial Calcium
title_sort influence of micrornas on mitochondrial calcium
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/107839
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6160583&blobtype=pdf
https://www.frontiersin.org/articles/10.3389/fphys.2018.01291/full
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