The Influence of MicroRNAs on Mitochondrial Calcium
Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulat...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2018
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107839 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6160583&blobtype=pdf https://www.frontiersin.org/articles/10.3389/fphys.2018.01291/full |
| Aporte de: |
| Sumario: | Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca<sup>2+</sup>]<sub>m</sub> uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca<sup>2+</sup>]<sub>m</sub> levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca<sup>2+</sup>]<sub>m</sub> handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca<sup>2+</sup>]<sub>m</sub> handling. |
|---|