Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media

Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy c...

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Autores principales:	Matesanz, Ana I., Jimenez Faraco, Eva, Ruiz, María Carolina, Balsa, Lucía Mariana, Navarro Ranninger, Carmen, León, Ignacio Esteban, Quiroga, Adoración G.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ciencias Exactas Química mononuclear structures biological interactions Pd(II) complex Pt(II) complex
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/109054 https://pubs.rsc.org/en/content/articlelanding/2018/QI/C7QI00446J
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-109054
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Química mononuclear structures biological interactions Pd(II) complex Pt(II) complex
spellingShingle	Ciencias Exactas Química mononuclear structures biological interactions Pd(II) complex Pt(II) complex Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G. Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
topic_facet	Ciencias Exactas Química mononuclear structures biological interactions Pd(II) complex Pt(II) complex
description	Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
format	Articulo Articulo
author	Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G.
author_facet	Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G.
author_sort	Matesanz, Ana I.
title	Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_short	Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full	Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_fullStr	Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full_unstemmed	Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_sort	mononuclear pd(ii) and pt(ii) complexes with an α-n-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/109054 https://pubs.rsc.org/en/content/articlelanding/2018/QI/C7QI00446J
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Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media

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