Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.

During the treatment of tuberculosis infection, oxidative stress due to anti-tubercular drugs may result in tissue inflammation. It was suggested that treatment with antioxidant drugs could be beneficial as an adjunct to anti-tuberculosis drug therapy. Recently our group has shown that several C-gly...

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Detalles Bibliográficos
Autores principales:	Zaro, María José, Bortolotti, Ana, Riafrecha, Leonardo Ezequiel, Concellón, Analía, Morbidoni, Héctor R., Colinas, Pedro Alfonso
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Química Dual mechanism Glycomimetic Tuberculosis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/123863
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-123863
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Dual mechanism Glycomimetic Tuberculosis
spellingShingle	Química Dual mechanism Glycomimetic Tuberculosis Zaro, María José Bortolotti, Ana Riafrecha, Leonardo Ezequiel Concellón, Analía Morbidoni, Héctor R. Colinas, Pedro Alfonso Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
topic_facet	Química Dual mechanism Glycomimetic Tuberculosis
description	During the treatment of tuberculosis infection, oxidative stress due to anti-tubercular drugs may result in tissue inflammation. It was suggested that treatment with antioxidant drugs could be beneficial as an adjunct to anti-tuberculosis drug therapy. Recently our group has shown that several C-glycosides are inhibitors of Mycobacterium tuberculosis β-carbonic anhydrases (CAs, EC 4.2.1.1). In an effort to develop novel chemotherapeutic agents against tuberculosis, the anti-tubercular and antioxidant activities of a series of C-glycosides containing the phenol or the methoxyaryl moiety were studied. Many compounds showed inhibition of growth of M. tuberculosis H37Rv strain and good antioxidant ability. A glycomimetic incorporating the 3-hydroxyphenyl moiety showed the best activity profile and therefore this functionality represents lead for the development of novel anti-tubercular agents with dual mechanisms of action.
format	Articulo Articulo
author	Zaro, María José Bortolotti, Ana Riafrecha, Leonardo Ezequiel Concellón, Analía Morbidoni, Héctor R. Colinas, Pedro Alfonso
author_facet	Zaro, María José Bortolotti, Ana Riafrecha, Leonardo Ezequiel Concellón, Analía Morbidoni, Héctor R. Colinas, Pedro Alfonso
author_sort	Zaro, María José
title	Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
title_short	Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
title_full	Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
title_fullStr	Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
title_full_unstemmed	Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.
title_sort	anti-tubercular and antioxidant activities of c-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against mycobacterium tuberculosis.
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/123863
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Anti-tubercular and antioxidant activities of C-glycosyl carbonic anhydrase inhibitors: towards the development of novel chemotherapeutic agents against Mycobacterium tuberculosis.

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