Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes

Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like a...

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Autores principales: Gaspar Tosato, Maira, Maya Girón, Julie Viviana, Martin, Airton Abrahão, Tippavajhala, Vamshi Krishna, Fernández Lorenzo de Mele, Mónica Alicia, Dicelio, Lelia E.
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Química
Resveratrol
Transdermal drug delivery
Liposomes
Nanoparticles
Confocal Raman spectroscopy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124996
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124996
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Resveratrol
Transdermal drug delivery
Liposomes
Nanoparticles
Confocal Raman spectroscopy
spellingShingle Química
Resveratrol
Transdermal drug delivery
Liposomes
Nanoparticles
Confocal Raman spectroscopy
Gaspar Tosato, Maira
Maya Girón, Julie Viviana
Martin, Airton Abrahão
Tippavajhala, Vamshi Krishna
Fernández Lorenzo de Mele, Mónica Alicia
Dicelio, Lelia E.
Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
topic_facet Química
Resveratrol
Transdermal drug delivery
Liposomes
Nanoparticles
Confocal Raman spectroscopy
description Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier.
format Articulo
Preprint
author Gaspar Tosato, Maira
Maya Girón, Julie Viviana
Martin, Airton Abrahão
Tippavajhala, Vamshi Krishna
Fernández Lorenzo de Mele, Mónica Alicia
Dicelio, Lelia E.
author_facet Gaspar Tosato, Maira
Maya Girón, Julie Viviana
Martin, Airton Abrahão
Tippavajhala, Vamshi Krishna
Fernández Lorenzo de Mele, Mónica Alicia
Dicelio, Lelia E.
author_sort Gaspar Tosato, Maira
title Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
title_short Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
title_full Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
title_fullStr Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
title_full_unstemmed Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
title_sort comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/124996
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