Insulin resistance: the linchpin between prediabetes and cardiovascular disease

The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programm...

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Autores principales:	Salazar, Martín R., Carbajal, Horacio Antonio, Espeche, Walter Gastón, Aizpurúa, Marcelo, Leiva Sisnieguez, Carlos Enrique, Leiva Sisnieguez, Betty Cecilia, Stavile, Rodolfo Nicolás, March, Carlos E., Reaven, Gerald M.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Médicas Prediabetes Cardiovascular disease Insulin resistance
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/136298
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-136298
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Prediabetes Cardiovascular disease Insulin resistance
spellingShingle	Ciencias Médicas Prediabetes Cardiovascular disease Insulin resistance Salazar, Martín R. Carbajal, Horacio Antonio Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Carlos Enrique Leiva Sisnieguez, Betty Cecilia Stavile, Rodolfo Nicolás March, Carlos E. Reaven, Gerald M. Insulin resistance: the linchpin between prediabetes and cardiovascular disease
topic_facet	Ciencias Médicas Prediabetes Cardiovascular disease Insulin resistance
description	The aim of this study was to test the hypothesis that cardiovascular disease occurs to the greatest extent in persons with prediabetes mellitus who are also insulin resistant. In 2003, 664 non-diabetic women (n = 457) and men (n = 207), aged 52 ± 16 and 53 ± 15 years, were surveyed during a programme for cardiovascular disease prevention. Fasting plasma glucose concentrations defined participants as having normal fasting plasma glucose (fasting plasma glucose <5.6 mmol/L) or prediabetes mellitus (fasting plasma glucose ⩾ 5.6 and <7.0 mmol/L). The tertile of prediabetes mellitus subjects with the highest fasting plasma insulin concentration was classified as insulin resistant. Baseline cardiovascular disease risk factors were accentuated in prediabetes mellitus versus normal fasting glucose, particularly in prediabetes mellitus/insulin resistant. In 2012, 86% of the sample were surveyed again, and the crude incidence for cardiovascular disease was higher in subjects with prediabetes mellitus versus normal fasting glucose (13.7 vs 6.0/100 persons/10 years; age- and sex-adjusted hazard ratio = 1.88, p = 0.052). In prediabetes mellitus, the crude incidences were 22.9 versus 9.6/100 persons/10 years in insulin resistant versus non-insulin resistant persons (age- and sex-adjusted hazard ratio = 2.36, p = 0.040). In conclusion, cardiovascular disease risk was accentuated in prediabetes mellitus/insulin resistant individuals, with a relative risk approximately twice as high compared to prediabetes mellitus/non-insulin resistant subjects.
format	Articulo Articulo
author	Salazar, Martín R. Carbajal, Horacio Antonio Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Carlos Enrique Leiva Sisnieguez, Betty Cecilia Stavile, Rodolfo Nicolás March, Carlos E. Reaven, Gerald M.
author_facet	Salazar, Martín R. Carbajal, Horacio Antonio Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Carlos Enrique Leiva Sisnieguez, Betty Cecilia Stavile, Rodolfo Nicolás March, Carlos E. Reaven, Gerald M.
author_sort	Salazar, Martín R.
title	Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_short	Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_full	Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_fullStr	Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_full_unstemmed	Insulin resistance: the linchpin between prediabetes and cardiovascular disease
title_sort	insulin resistance: the linchpin between prediabetes and cardiovascular disease
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/136298
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bdutipo_str	Repositorios
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Insulin resistance: the linchpin between prediabetes and cardiovascular disease

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