Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets

Fatty acid binding proteins (FABPs) are small intracellular proteins that reversibly bind fatty acids and other hydrophobic ligands. In cestodes, due to their inability to synthesise fatty acids and cholesterol de novo, FABPs, together with other lipid binding proteins, have been proposed as essenti...

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Detalles Bibliográficos
Autores principales: Bélgamo, Julián Alberto, Alberca, Lucas Nicolás, Pórfido, Jorge Luis, Caram Romero, Franco Nahuel, Rodríguez, Santiago, Talevi, Alan, Córsico, Betina, Franchini, Gisela Raquel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Bioquímica
Drug repurposing
Target repurposing
FABP
Echinococcus spp
Virtual screening
Neglected tropical diseases
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/136766
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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