Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice

Prolactin (PRL) has been shown to exert many different actions in various biological systems. Polyamines are known to influence the growth and function of the seminal vesicles (SV). Furthermore, ornithine decarboxylase (ODC) is considered a key enzyme In the biosynthesis of polyamines and Is regulat...

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Autores principales: Gonzalez, S. I., Chandrashekar, Varadaraj, Shire, J. G. M., Luthy, Isabel Alicia, Bartke, Andrzej, Calandra, Ricardo Saúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 1991
Materias:
Biología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146622
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-146622
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
spellingShingle Biología
Gonzalez, S. I.
Chandrashekar, Varadaraj
Shire, J. G. M.
Luthy, Isabel Alicia
Bartke, Andrzej
Calandra, Ricardo Saúl
Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
topic_facet Biología
description Prolactin (PRL) has been shown to exert many different actions in various biological systems. Polyamines are known to influence the growth and function of the seminal vesicles (SV). Furthermore, ornithine decarboxylase (ODC) is considered a key enzyme In the biosynthesis of polyamines and Is regulated by PRL in certain target tissues. Adult Ames dwarf mice (df/df), genetically deficient In PRL, were used for this study. The experimental groups were as follows: Group 1, pituitary-grafted; Group 2, sham-operated; Group 3, castrated + testosterone propionate (TP)-treated (25 sag/mouse, 3 times/wk, s.c.) + grafted; and Group 4, castrated + TP as above. The animals were killed 40 days later, and polyamines and ODC activity in SV and liverwere determined. Serum PRL, FSH, and testosterone (T) were also measured. In the grafted groups, there were significant elevations in serum PRL and FSH levels. In the gonad-intact, pituitary-grafted group, animals exhibited an elevation in plasma T levels, and similar levels were achieved in the castrated, androgen-replaced groups. In hyperprolactinemic mice, the weights of SV were significantly greater than in the corresponding control groups. The relative weights of the SV showed a similar pattern. An increase in ODC activity was observed in both SV and liver in hyperprolactinemic groups. In those animals in which senam T levels were held constant, an increase in the enzyme activity in SV was detected in hyperprolactinemic group whereas in liver,no significant difference was observed. Concentrations of polyamines in the SV were increased in hyperprolactinemic, castrated, TP-treated mice. The present results indicate that PRL can exert a direct stimulatory effect on the growth, ODC activity, and polyamine levels in the SV.
format Articulo
Articulo
author Gonzalez, S. I.
Chandrashekar, Varadaraj
Shire, J. G. M.
Luthy, Isabel Alicia
Bartke, Andrzej
Calandra, Ricardo Saúl
author_facet Gonzalez, S. I.
Chandrashekar, Varadaraj
Shire, J. G. M.
Luthy, Isabel Alicia
Bartke, Andrzej
Calandra, Ricardo Saúl
author_sort Gonzalez, S. I.
title Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
title_short Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
title_full Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
title_fullStr Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
title_full_unstemmed Effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
title_sort effects of hyperprolactinemia on ornithine decarboxylase activity and polyamine levels in seminal vesicles of genetically prolactin-deficient adult dwarf mice
publishDate 1991
url http://sedici.unlp.edu.ar/handle/10915/146622
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