The endocrine heart: from the bench to the bedside and back to the bench

Two polypeptide hormones are produced, stored and secreted in a regulated manner by cardiac muscle cells (cardiocytes) of the atria of the heart of mammals. These are atrial natriuretic factor (ANF)1-3 and brain natriuretic peptide (BNP).4 They form part of a family of hormones referred to as natriu...

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Detalles Bibliográficos
Autor principal: de Bold, Adolfo J.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2005
Materias:
Ciencias Médicas
Atrial natriuretic factor
Brain natriuretic peptide
Ventricles
Atria
Fisiología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/146967
https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n2_september.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-146967
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Atrial natriuretic factor
Brain natriuretic peptide
Ventricles
Atria
Fisiología
spellingShingle Ciencias Médicas
Atrial natriuretic factor
Brain natriuretic peptide
Ventricles
Atria
Fisiología
de Bold, Adolfo J.
The endocrine heart: from the bench to the bedside and back to the bench
topic_facet Ciencias Médicas
Atrial natriuretic factor
Brain natriuretic peptide
Ventricles
Atria
Fisiología
description Two polypeptide hormones are produced, stored and secreted in a regulated manner by cardiac muscle cells (cardiocytes) of the atria of the heart of mammals. These are atrial natriuretic factor (ANF)1-3 and brain natriuretic peptide (BNP).4 They form part of a family of hormones referred to as natriuretic peptides (NP). A third member: CNP, is not natriuretic and is not produced by cardiocytes. Both ANF and BNP are co-stored in atrial cardiocytes in storage granules referred to as specific atrial granules. Some confusion has recently developed in the clinical literature as to the precise cell type where this secretory function resides, as well as to the peptide storage form and the location of the secretory function, which, of late, is often quoted as being the atria for ANF and the ventricular muscle for BNP. By Northern blot analysis, immunocytochemistry, in situ hybridization, radioimmunoassay and oligonucleotide array, ANF and BNP are far more abundant in the atria than the ventricles. In fact, the level of expression of NP in the normal ventricles is negligible compared to that of the atria.
format Articulo
Revision
author de Bold, Adolfo J.
author_facet de Bold, Adolfo J.
author_sort de Bold, Adolfo J.
title The endocrine heart: from the bench to the bedside and back to the bench
title_short The endocrine heart: from the bench to the bedside and back to the bench
title_full The endocrine heart: from the bench to the bedside and back to the bench
title_fullStr The endocrine heart: from the bench to the bedside and back to the bench
title_full_unstemmed The endocrine heart: from the bench to the bedside and back to the bench
title_sort endocrine heart: from the bench to the bedside and back to the bench
publishDate 2005
url http://sedici.unlp.edu.ar/handle/10915/146967
https://pmr.safisiol.org.ar/wp-content/uploads/2022/02/vol1_n2_september.pdf
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