Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina

The Kilham rat virus (KRV) is a parvovirus originally isolated from a rat sarcoma in the late 1950s. The clinical signs associated with a natural KRV infection include foetal resorption in dams, runtin, ataxia, cerebellar hypoplasia and jaundice in suckling rats, and sudden death, scrotal cyanosis,...

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Autores principales: Cagliada, María del Pilar Lilia, Carbone, Cecilia, Ayala, Miguel Ángel, Laborde, Juan Martín, Maschi, Fabricio Alejandro, Milocco, Silvana Nora, Bonzo, Estela Beatriz, Cid de la Paz, Viviana, Galosi, Cecilia Mónica
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Veterinarias
diagnosis
haemagglutination inhibition test
Kilham rat virus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/150396
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-150396
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
diagnosis
haemagglutination inhibition test
Kilham rat virus
spellingShingle Ciencias Veterinarias
diagnosis
haemagglutination inhibition test
Kilham rat virus
Cagliada, María del Pilar Lilia
Carbone, Cecilia
Ayala, Miguel Ángel
Laborde, Juan Martín
Maschi, Fabricio Alejandro
Milocco, Silvana Nora
Bonzo, Estela Beatriz
Cid de la Paz, Viviana
Galosi, Cecilia Mónica
Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
topic_facet Ciencias Veterinarias
diagnosis
haemagglutination inhibition test
Kilham rat virus
description The Kilham rat virus (KRV) is a parvovirus originally isolated from a rat sarcoma in the late 1950s. The clinical signs associated with a natural KRV infection include foetal resorption in dams, runtin, ataxia, cerebellar hypoplasia and jaundice in suckling rats, and sudden death, scrotal cyanosis, abdominal swelling and dehydration in juvenile rats. The ability of this virus to produce persistent infections has resulted in a high frequency of contamination of cell cultures and transplantable-tumor system. In addition, the virus may interfere with research in other ways. The remarkable resistance to environmental conditions determines the importance of the detection and control of this agent, especially in the laboratory animal production. This study determines the seroprevalence of Kilham antibodies from sera of adult rats from conventional facilities, using the haemagglutination inhibition test. The seroprevalence varied between 27.8% and 75%. This result confirms that the virus is circulating in Argentinean conventional facilities and might be interfering with research. The recognized Kilham virus may be prevented from supply sources by implementing a health monitoring schedule including a regular serological surveillance, and by keeping the animals under barrier systems.
format Articulo
Comunicacion
author Cagliada, María del Pilar Lilia
Carbone, Cecilia
Ayala, Miguel Ángel
Laborde, Juan Martín
Maschi, Fabricio Alejandro
Milocco, Silvana Nora
Bonzo, Estela Beatriz
Cid de la Paz, Viviana
Galosi, Cecilia Mónica
author_facet Cagliada, María del Pilar Lilia
Carbone, Cecilia
Ayala, Miguel Ángel
Laborde, Juan Martín
Maschi, Fabricio Alejandro
Milocco, Silvana Nora
Bonzo, Estela Beatriz
Cid de la Paz, Viviana
Galosi, Cecilia Mónica
author_sort Cagliada, María del Pilar Lilia
title Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
title_short Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
title_full Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
title_fullStr Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
title_full_unstemmed Prevalence of antibodies against Kilham virus in experimental rat colonies of Argentina
title_sort prevalence of antibodies against kilham virus in experimental rat colonies of argentina
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/150396
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