A hierarchical model for the control of epigenetic aging in mammals

Regulatory mechanisms range from a single level of control in simple metazoans to multi-level hierarchical control networks in higher animals. Organismal regulation encompasses homeostatic and circadian networks that are interconnected, with no documented exceptions. The epigenetic clock is a highly...

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Autores principales:	Lehmann, Marianne, Canatelli Mallat, Martina, Chiavellini, Priscila, Goya, Rodolfo Gustavo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2020
Materias:	Ciencias Médicas Organismal aging hierarchical structure control networks epigenetic driver DNA methylation epigenetic rejuvenation
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/151824
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-151824
record_format	dspace
spelling	I19-R120-10915-1518242023-04-20T04:08:33Z http://sedici.unlp.edu.ar/handle/10915/151824 issn:1568-1637 A hierarchical model for the control of epigenetic aging in mammals Lehmann, Marianne Canatelli Mallat, Martina Chiavellini, Priscila Goya, Rodolfo Gustavo 2020 2023-04-19T18:46:12Z en Ciencias Médicas Organismal aging hierarchical structure control networks epigenetic driver DNA methylation epigenetic rejuvenation Regulatory mechanisms range from a single level of control in simple metazoans to multi-level hierarchical control networks in higher animals. Organismal regulation encompasses homeostatic and circadian networks that are interconnected, with no documented exceptions. The epigenetic clock is a highly accurate biomarker of age in humans, defined by a mathematical algorithm based on the methylation of a subset of age-related CpG sites on DNA. Experimental evidence suggests the existence of an underlying regulatory mechanism. By analogy with other integrative systems as the neuroendocrine-immune network and the circadian clocks, a hierarchical organization in the control of the ticking rate of the epigenetic clock is hypothesized here. The hierarchical organization of the neuroendocrine, immune and circadian systems is briefly reviewed. This is followed by a brief review of the epigenetic clock at cell level. Finally, different lines of indirect evidence, consistent with the existence of a central pacemaker controlling the ticking rate of the epigenetic clock at organismal level are discussed. The concluding remarks put the hierarchical model proposed for the control of the clock into an evolutionary perspective. Within this perspective, the present hypothesis is intended as a conceptual outline based on designs consistently favored by evolution in higher animals. Instituto de Investigaciones Bioquímicas de La Plata Articulo Articulo http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/pdf
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Organismal aging hierarchical structure control networks epigenetic driver DNA methylation epigenetic rejuvenation
spellingShingle	Ciencias Médicas Organismal aging hierarchical structure control networks epigenetic driver DNA methylation epigenetic rejuvenation Lehmann, Marianne Canatelli Mallat, Martina Chiavellini, Priscila Goya, Rodolfo Gustavo A hierarchical model for the control of epigenetic aging in mammals
topic_facet	Ciencias Médicas Organismal aging hierarchical structure control networks epigenetic driver DNA methylation epigenetic rejuvenation
description	Regulatory mechanisms range from a single level of control in simple metazoans to multi-level hierarchical control networks in higher animals. Organismal regulation encompasses homeostatic and circadian networks that are interconnected, with no documented exceptions. The epigenetic clock is a highly accurate biomarker of age in humans, defined by a mathematical algorithm based on the methylation of a subset of age-related CpG sites on DNA. Experimental evidence suggests the existence of an underlying regulatory mechanism. By analogy with other integrative systems as the neuroendocrine-immune network and the circadian clocks, a hierarchical organization in the control of the ticking rate of the epigenetic clock is hypothesized here. The hierarchical organization of the neuroendocrine, immune and circadian systems is briefly reviewed. This is followed by a brief review of the epigenetic clock at cell level. Finally, different lines of indirect evidence, consistent with the existence of a central pacemaker controlling the ticking rate of the epigenetic clock at organismal level are discussed. The concluding remarks put the hierarchical model proposed for the control of the clock into an evolutionary perspective. Within this perspective, the present hypothesis is intended as a conceptual outline based on designs consistently favored by evolution in higher animals.
format	Articulo Articulo
author	Lehmann, Marianne Canatelli Mallat, Martina Chiavellini, Priscila Goya, Rodolfo Gustavo
author_facet	Lehmann, Marianne Canatelli Mallat, Martina Chiavellini, Priscila Goya, Rodolfo Gustavo
author_sort	Lehmann, Marianne
title	A hierarchical model for the control of epigenetic aging in mammals
title_short	A hierarchical model for the control of epigenetic aging in mammals
title_full	A hierarchical model for the control of epigenetic aging in mammals
title_fullStr	A hierarchical model for the control of epigenetic aging in mammals
title_full_unstemmed	A hierarchical model for the control of epigenetic aging in mammals
title_sort	hierarchical model for the control of epigenetic aging in mammals
publishDate	2020
url	http://sedici.unlp.edu.ar/handle/10915/151824
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_version_	1765660030796824576

A hierarchical model for the control of epigenetic aging in mammals

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