S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria

In bacteria, as in other microorganisms, surface compounds interact with different pattern recognition receptors expressed by host cells, which usually triggers a variety of cellular responses that result in immunomodulation. The S-layer is a two-dimensional macromolecular crystalline structure for...

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Autores principales: Assandri, Matías Hernán, Malamud, Mariano, Trejo, Fernando Miguel, Serradell, María de los Ángeles
Formato: Articulo
Lenguaje:Inglés
Publicado: 2023
Materias:
Biología
Microbe-associated molecular patterns
Immunodulation
S-layer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/153648
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-153648
record_format dspace
spelling I19-R120-10915-1536482023-05-31T04:06:08Z http://sedici.unlp.edu.ar/handle/10915/153648 issn:2666-5174 S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria Assandri, Matías Hernán Malamud, Mariano Trejo, Fernando Miguel Serradell, María de los Ángeles 2023 2023-05-30T15:03:42Z en Biología Microbe-associated molecular patterns Immunodulation S-layer In bacteria, as in other microorganisms, surface compounds interact with different pattern recognition receptors expressed by host cells, which usually triggers a variety of cellular responses that result in immunomodulation. The S-layer is a two-dimensional macromolecular crystalline structure formed by (glyco)-protein subunits that covers the surface of many species of Bacteria and almost all Archaea. In Bacteria, the presence of S-layer has been described in both pathogenic and non-pathogenic strains. As surface components, special attention deserves the role that S-layer proteins (SLPs) play in the interaction of bacterial cells with humoral and cellular components of the immune system. In this sense, some differences can be predicted between pathogenic and nonpathogenic bacteria. In the first group, the S-layer constitutes an important virulence factor, which in turn makes it a potential therapeutic target. For the other group, the growing interest to understand the mechanisms of action of commensal microbiota and probiotic strains has prompted the studies of the role of the S-layer in the interaction between the host immune cells and bacteria bearing this surface structure. In this review, we aim to summarize the main latest reports and the perspectives of bacterial SLPs as immune players, focusing on those from pathogenic and commensal/probiotic most studied species. Facultad de Ciencias Exactas Centro de Investigación y Desarrollo en Criotecnología de Alimentos Articulo Articulo http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) application/pdf
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Microbe-associated molecular patterns
Immunodulation
S-layer
spellingShingle Biología
Microbe-associated molecular patterns
Immunodulation
S-layer
Assandri, Matías Hernán
Malamud, Mariano
Trejo, Fernando Miguel
Serradell, María de los Ángeles
S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
topic_facet Biología
Microbe-associated molecular patterns
Immunodulation
S-layer
description In bacteria, as in other microorganisms, surface compounds interact with different pattern recognition receptors expressed by host cells, which usually triggers a variety of cellular responses that result in immunomodulation. The S-layer is a two-dimensional macromolecular crystalline structure formed by (glyco)-protein subunits that covers the surface of many species of Bacteria and almost all Archaea. In Bacteria, the presence of S-layer has been described in both pathogenic and non-pathogenic strains. As surface components, special attention deserves the role that S-layer proteins (SLPs) play in the interaction of bacterial cells with humoral and cellular components of the immune system. In this sense, some differences can be predicted between pathogenic and nonpathogenic bacteria. In the first group, the S-layer constitutes an important virulence factor, which in turn makes it a potential therapeutic target. For the other group, the growing interest to understand the mechanisms of action of commensal microbiota and probiotic strains has prompted the studies of the role of the S-layer in the interaction between the host immune cells and bacteria bearing this surface structure. In this review, we aim to summarize the main latest reports and the perspectives of bacterial SLPs as immune players, focusing on those from pathogenic and commensal/probiotic most studied species.
format Articulo
Articulo
author Assandri, Matías Hernán
Malamud, Mariano
Trejo, Fernando Miguel
Serradell, María de los Ángeles
author_facet Assandri, Matías Hernán
Malamud, Mariano
Trejo, Fernando Miguel
Serradell, María de los Ángeles
author_sort Assandri, Matías Hernán
title S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
title_short S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
title_full S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
title_fullStr S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
title_full_unstemmed S-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
title_sort s-layer proteins as immune players: tales from pathogenic and non-pathogenic bacteria
publishDate 2023
url http://sedici.unlp.edu.ar/handle/10915/153648
work_keys_str_mv AT assandrimatiashernan slayerproteinsasimmuneplayerstalesfrompathogenicandnonpathogenicbacteria
AT malamudmariano slayerproteinsasimmuneplayerstalesfrompathogenicandnonpathogenicbacteria
AT trejofernandomiguel slayerproteinsasimmuneplayerstalesfrompathogenicandnonpathogenicbacteria
AT serradellmariadelosangeles slayerproteinsasimmuneplayerstalesfrompathogenicandnonpathogenicbacteria
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