Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats

The antihyperglycaemic effect of Casearia sylvestris aqueous extract (CS) and its flavonoidic fraction using in vivo models in streptozotocin-induced diabetic rats was evaluated. CS (500 mg/kg) reduced blood glucose in rats three weeks after a single oral dose. The blood glucose significantly decrea...

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Detalles Bibliográficos
Autores principales:	Buccioli, Paulo T., Bortolin, Raul H., Furini, Gleison T., Cincotto, Danielli U., Sousa, Janaína H., França, Suzelei C., Oliveira, Luciana, Pereira, Paulo S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia antihyperglycemic effect; casearia sylvestris; flavonoid Farmacología Diabetes Mellitus Tipo 2
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/18259 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_11.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-18259
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antihyperglycemic effect; casearia sylvestris; flavonoid Farmacología Diabetes Mellitus Tipo 2
spellingShingle	Farmacia antihyperglycemic effect; casearia sylvestris; flavonoid Farmacología Diabetes Mellitus Tipo 2 Buccioli, Paulo T. Bortolin, Raul H. Furini, Gleison T. Cincotto, Danielli U. Sousa, Janaína H. França, Suzelei C. Oliveira, Luciana Pereira, Paulo S. Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
topic_facet	Farmacia antihyperglycemic effect; casearia sylvestris; flavonoid Farmacología Diabetes Mellitus Tipo 2
description	The antihyperglycaemic effect of Casearia sylvestris aqueous extract (CS) and its flavonoidic fraction using in vivo models in streptozotocin-induced diabetic rats was evaluated. CS (500 mg/kg) reduced blood glucose in rats three weeks after a single oral dose. The blood glucose significantly decreased in a test of tolerance to insulin. Phytochemical investigation on TLC, HPLC-DAD and NMR spectral analysis of extract and fractions confirmed the presence of flavonoids. These results direct the hypothesis that CS improves glucose metabolism by reducing insulin resistance, and it may be useful for the treatment of type 2 diabetes.
format	Articulo Articulo
author	Buccioli, Paulo T. Bortolin, Raul H. Furini, Gleison T. Cincotto, Danielli U. Sousa, Janaína H. França, Suzelei C. Oliveira, Luciana Pereira, Paulo S.
author_facet	Buccioli, Paulo T. Bortolin, Raul H. Furini, Gleison T. Cincotto, Danielli U. Sousa, Janaína H. França, Suzelei C. Oliveira, Luciana Pereira, Paulo S.
author_sort	Buccioli, Paulo T.
title	Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
title_short	Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
title_full	Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
title_fullStr	Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
title_full_unstemmed	Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
title_sort	antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/18259 http://www.latamjpharm.org/resumenes/31/3/LAJOP_31_3_1_11.pdf
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Antihyperglycemic effect of casearia sylvestris leaves extract in streptozotocin induced diabetic rats

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