Stability assessment of cinnarizine in self-emulsifying drug delivery systems

The current study was designed to evaluate the chemical and physical stability of cinnarizine within self-emulsifying drug delivery systems. According to International Conference of Harmonization guidelines, the selected formulations were enrolled into both accelerated and long-term stability studie...

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Autores principales:	Shahba, Ahmad A., Alanazi, Fars K., Mohsin, Kazi, Abdel-Hamid, Magdi
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Cinarizina Sistemas de Liberación de Medicamentos Cinnarizine Lipid-based formulations Oral drug delivery SEDDS SNEDDS Stability
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20181 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-20181
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Cinarizina Sistemas de Liberación de Medicamentos Cinnarizine Lipid-based formulations Oral drug delivery SEDDS SNEDDS Stability
spellingShingle	Farmacia Cinarizina Sistemas de Liberación de Medicamentos Cinnarizine Lipid-based formulations Oral drug delivery SEDDS SNEDDS Stability Shahba, Ahmad A. Alanazi, Fars K. Mohsin, Kazi Abdel-Hamid, Magdi Stability assessment of cinnarizine in self-emulsifying drug delivery systems
topic_facet	Farmacia Cinarizina Sistemas de Liberación de Medicamentos Cinnarizine Lipid-based formulations Oral drug delivery SEDDS SNEDDS Stability
description	The current study was designed to evaluate the chemical and physical stability of cinnarizine within self-emulsifying drug delivery systems. According to International Conference of Harmonization guidelines, the selected formulations were enrolled into both accelerated and long-term stability studies up to 6 and 12 months, respectively. The chemical stability of the formulations was assessed periodically based on the intact cinnarizine level. The physical stability was evaluated based on the physical appearance and color change pattern of the formulations. The accelerated stability study revealed significant cinnarizine degradation in all the tested formulations at 3 and 6 months. All the tested formulations experienced sharp discoloration within 6 months of storage. On the other hand, the long-term stability study showed no significant cinnarizine degradation or color change within the formulations containing 100 % saturated medium chain glycerides (as oil component). While, the formulations containing 50 % unsaturated long chain fatty acids showed considerable drug degradation as well as significant discoloration. Accordingly, The formulations containing 100 % saturated medium chain glycerides provide excellent chemical and physical stability pattern and have the potential to provide a stable dosage form of cinnarizine.
format	Articulo Articulo
author	Shahba, Ahmad A. Alanazi, Fars K. Mohsin, Kazi Abdel-Hamid, Magdi
author_facet	Shahba, Ahmad A. Alanazi, Fars K. Mohsin, Kazi Abdel-Hamid, Magdi
author_sort	Shahba, Ahmad A.
title	Stability assessment of cinnarizine in self-emulsifying drug delivery systems
title_short	Stability assessment of cinnarizine in self-emulsifying drug delivery systems
title_full	Stability assessment of cinnarizine in self-emulsifying drug delivery systems
title_fullStr	Stability assessment of cinnarizine in self-emulsifying drug delivery systems
title_full_unstemmed	Stability assessment of cinnarizine in self-emulsifying drug delivery systems
title_sort	stability assessment of cinnarizine in self-emulsifying drug delivery systems
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20181 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_1_9.pdf
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bdutipo_str	Repositorios
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Stability assessment of cinnarizine in self-emulsifying drug delivery systems

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