The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues
11β-hydroxysteroid dehydrogenase (11β-HSD) plays an important part in mediating glucocorticoid action, catalyzing the interconversion of corticosterone (B) and dehydrocorticosterone (A) in rodents. The aim of our study is to investigate the effects of (+)-gossypol (G+) on 11β-HSD. Adult ICR mice wer...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
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2012
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/20206 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_1.pdf |
| Aporte de: |
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I19-R120-10915-20206 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Corticosterona Suero Tejidos 11-beta-Hidroxiesteroide Deshidrogenasas Corticosterone Dehydrocorticosterone (+)-Gossypol HPLC 11β-hydroxysteroid Dehydrogenase |
| spellingShingle |
Farmacia Corticosterona Suero Tejidos 11-beta-Hidroxiesteroide Deshidrogenasas Corticosterone Dehydrocorticosterone (+)-Gossypol HPLC 11β-hydroxysteroid Dehydrogenase Qiu, Xiangjun Li, Wanshu Li, Junwei Wang, Mengmeng Wang, Jia Chen, Lianguo Sun, Wei Zhang, Likang Wen, Congcong Ge, Renshan Hu, Guoxin The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| topic_facet |
Farmacia Corticosterona Suero Tejidos 11-beta-Hidroxiesteroide Deshidrogenasas Corticosterone Dehydrocorticosterone (+)-Gossypol HPLC 11β-hydroxysteroid Dehydrogenase |
| description |
11β-hydroxysteroid dehydrogenase (11β-HSD) plays an important part in mediating glucocorticoid action, catalyzing the interconversion of corticosterone (B) and dehydrocorticosterone (A) in rodents. The aim of our study is to investigate the effects of (+)-gossypol (G+) on 11β-HSD. Adult ICR mice were given B and B + (G+) by intraperitoneal injection. The activity of 11β-HSD was evaluated by measuring the ratio of A and B, meanwhile the effects of (+)-gossypol on the conversion rate of B to A was determined with HPLC. Serum A/B levels of the B+(G+) group decreased by 2.42, 7.32, 17.85, 31.39, and 40.02 % compared to the B group at each measured time interval. A/B levels at 1 h for the B + (G+) group decreased by 43.78, 21.29 and 34.47% in liver, kidney and adrenal glands, respectively, in comparison to the B group. However, (+)-gossypol had no effect on brain and testis. (+)-Gossypol was an inhibitor of 11β-HSD. |
| format |
Articulo Comunicacion |
| author |
Qiu, Xiangjun Li, Wanshu Li, Junwei Wang, Mengmeng Wang, Jia Chen, Lianguo Sun, Wei Zhang, Likang Wen, Congcong Ge, Renshan Hu, Guoxin |
| author_facet |
Qiu, Xiangjun Li, Wanshu Li, Junwei Wang, Mengmeng Wang, Jia Chen, Lianguo Sun, Wei Zhang, Likang Wen, Congcong Ge, Renshan Hu, Guoxin |
| author_sort |
Qiu, Xiangjun |
| title |
The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| title_short |
The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| title_full |
The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| title_fullStr |
The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| title_full_unstemmed |
The effects of (+)-Gossypol on 11β-HSD and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| title_sort |
effects of (+)-gossypol on 11β-hsd and the concentration of corticosterone and dehydrocorticosterone in mice serum and tissues |
| publishDate |
2012 |
| url |
http://sedici.unlp.edu.ar/handle/10915/20206 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_1.pdf |
| work_keys_str_mv |
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Repositorios |
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